Publications by authors named "Mengying Zuo"

Article Synopsis
  • The study explores the role of Manic Fringe (MFNG) in heart valve development, specifically its involvement in the endothelial-to-mesenchymal transition (EndMT) process, which is crucial for forming heart valves.
  • Researchers found that MFNG promotes EndMT by enhancing the Notch signaling pathway, and its loss leads to abnormal heart and valve development in zebrafish models.
  • A mutation in the MFNG gene was identified in patients with congenital heart defects, confirming that MFNG is vital in the development of heart valve malformations and may serve as a target for future diagnosis and treatments.
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Accurate skin lesion segmentation plays a fundamental role in computer-aided melanoma analysis. Recently, some FCN-based methods have been proposed and achieved promising results in lesion segmentation tasks. However, due to the variable shapes, different scales, noise interference, and ambiguous boundaries of skin lesions, the capabilities of lesion location and boundary delineation of these works are still insufficient.

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Left ventricular noncompaction (LVNC) is a particular type of cardiomyopathy with an excessively prominent trabecular meshwork and deep intertrabecular recesses in the left ventricle (LV). The clinical manifestation of LVNC is highly variable, ranging from no symptom to congestive heart failure, arrhythmia, thrombosis, and potentially sudden cardiac death. Approximately half of LVNC cases are hereditary.

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Background And Aims: Biallelic missense variants in PPA2 gene cause infantile sudden cardiac failure (SCFI; OMIM #617222) characterized by sudden cardiac failure, sudden cardiac death in infants. Here, we present an unusual survivor with one inherited plus one de novo variant in PPA2. Since next-generation sequencing (NGS) fails to resolve variant phasing, which require long-read sequencing to clarify the diagnosis.

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