The role of the CCL5-CCR5 axis in microglial activation leading to postoperative cognitive dysfunction.

Postoperative cognitive dysfunction (POCD) is a common complication following surgeries involving general anesthesia. Although the CCL5-CCR5 axis is implicated in various neurological conditions, its role in POCD remains unclear. In our POCD model, we observed an increase in CCL5 and CCR5 levels concurrent with microglial activation and significant upregulation of inflammatory cytokines IL-6 and IL-1β.

Population pharmacokinetics and limited sampling strategies of polymyxin B in critically ill patients.

Objectives: To characterize the pharmacokinetics (PK) of polymyxin B in Chinese critically ill patients. The factors significantly affecting PK parameters are identified, and a limited sampling strategy for therapeutic drug monitoring of polymyxin B is explored.

Methods: Thirty patients (212 samples) were included in a population PK analysis.