Publications by authors named "Mengying Lyu"
Extracellular glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has multiple interactions with various gut epithelial components. For instance, GAPDH in MG cells interacts with junctional adhesion molecule-2 (JAM-2) in Caco-2 cells and enhances tight junctions. However, the specificity of GAPDH toward JAM-2 and its role in the tight junctions in Caco-2 cells remain unclear.
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- Commensal intestinal bacteria in mice interact with gut epithelial cells through binding to specific receptors, but many of these receptors are still unidentified.
- The study identified a 30 kDa protein, junctional adhesion molecule-2 (JAM-2), which is part of the tight junction protein family, and was found to repair gut barriers damaged in cultured Caco-2 cells when treated with lactic acid bacteria (MG).
- Additionally, a 40 kDa moonlighting protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was identified, indicating that MG enhances gut barrier integrity through the interaction of GAPDH with JAM-2, highlighting the importance of gut bacteria in host-bacterial communication.
Background: The dried fruit of Chaenomeles speciosa, known as Chaenomelis Fructus or Zhoupi Mugua, is a type of traditional Chinese medicine (TCM) that is widely used to treat many diseases. Guangpi Mugua, the dried fruit of the Chaenomeles sinensis, is its most commonly known adulterant.
Objective: To establish a robust approach for the quality control and identification of Chaenomelis Fructus.