Spectrochim Acta A Mol Biomol Spectrosc
November 2023
The preparation of diclofenac sodium spheres by fluidized bed is a common production mode for the pharmaceutical preparations at present, but the critical material attributes in the production process is mostly analyzed off-line, which is time-consuming and laborious, and the analysis results lag behind. In this paper, the real-time in-line prediction of drug loading of diclofenac sodium and the release rate during the coating process was realized by using near infrared spectroscopy. For the best near infrared spectroscopy (NIRS) model of drug loading, R, R, RMSECV, RMSEP were 0.
View Article and Find Full Text PDFBackground: For thousands of years, traditional Chinese medicine (TCM) has been clinically proven, and doctors have highly valued the differences in utility between different species.
Objective: This study aims to replace the complex methods traditionally used for empirical identification by compensating for the information loss of a single sensor through data fusion. The research object of the study is Coptidis rhizoma (CR).
• The infection of SARS-CoV-2 lead to varying degrees of testicular pathological damage. • The NP antigen of SARS-CoV-2 was not found in male reproductive system of rhesus macaque. • Infection-associated inflammatory insult and sex hormone fluctuations may account for the testicular pathophysiology.
View Article and Find Full Text PDF• Delta variant of SARS-CoV-2 can effectively infect the • Delta variant grows faster than the early strain isolated from Wuhan in late 2019. • Shedding pattern, viral load and disease severity of Delta variant are similar to the early strain isolated from Wuhan. • This study supports the attributed rapid disease spread of the Delta variant.
View Article and Find Full Text PDFEnzyme-like nanomaterials have received significant attention for their high stability and low cost. However, most nanomaterials require complicated synthesis processes, limiting the range of their potential applications. In this study, a novel cerium-based nanomaterial was fabricated in a facile manner from a mixture of dipicolinic acid (DPA), guanosine 5'-monophosphate (GMP), and cerium acetate under ambient conditions.
View Article and Find Full Text PDFThere is a large and growing demand for the vigorous development of new high performance liquid chromatography stationary phases in order to solve complex phospholipids separation. Herein, phosphonium-based ionic liquid trioctyl(allyl)phosphonium bromide ([P]Br) was first synthesized with trioctylphosphine and allyl bromide. With [P]Br as the polymerizable monomer, polymerized phosphonium ionic liquid functionalized silica microsphere (PIL@SiO) was further synthetized via click chemistry reaction.
View Article and Find Full Text PDFOrbiviruses are arboviruses with 10 double-stranded linear RNA segments, and some have been identified as pathogens of dramatic epizootics in both wild and domestic ruminants. Tibet orbivirus (TIBOV) is a new orbivirus isolated from hematophagous insects in recent decades, and, currently, most of the strains have been isolated from insects in PR China, except for two from Japan. In this study, we isolated a novel reassortment TIBOV strain, YN15-283-01, from spp.
View Article and Find Full Text PDFAn amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFMosquito-borne viruses such as Zika virus, Japanese Encephalitis virus and Dengue virus present an increasing global health concern. However, in-depth knowledge of the distribution and diversity of mosquito-associated viruses and their related vectors remains limited, especially for China. To promote their understanding, we present the first comprehensive dataset of the distribution and diversity of these viruses and their related vectors in China (including Taiwan, Hong Kong and Macau).
View Article and Find Full Text PDFVigorously developing new high performance liquid chromatography (HPLC) stationary phases to meet the versatile separation requirements is still an important issue in the field of analytical chemistry. Conjugated microporous polymers (CMPs) are a new type of three-dimensional network porous material with high specific surface area, good chemical stability and superhydrophobicity. Herein, we firstly report the synthesis and applications of CMPs@SiO material for HPLC stationary phase.
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