[1,5]-Oxy/Thio/Azole Sigmatropic Rearrangement versus Indolyl-Spirocyclization: Tandem Reactions of 2-Azidobenzoate with Isocyanides for Accessing Quinazolin-4(3)-ones.

A general protocol for the synthesis of a variety of functionalized quinazolinones has been developed through a sequential Pd-catalyzed coupling/1,5-alkyloxy/thio/azole shift/6π electrocyclization reaction of isocyanides and 2-carbonylaryl azides. When 3-(2-isocyanoethyl)indoles were utilized, an unusual competitive reaction between [1,5]-shift and indole-spirocyclization was observed, which renders a modular synthesis of quinazolinones and spiroindolenine-3,3'-pyrrolo[2,1-]quinazolinones in a highly chemoselective manner.

Intelligent and biocompatible cellulose aerogels featured with high-elastic and fast-hemostatic for epistaxis and wound healing.

Nasal tamponade is a commonly employed and highly effective treatment method for preventing nasal bleeding. However, the current nasal packing hemostatic materials exhibit some limitations, such as low hemostatic efficiency, the potential for causing secondary injury when removed from the nasal cavity, limited intelligence in their design, and an inability to promote the healing of nasal mucosa wounds. Herein, we report the fabrication of a smart cellulose aerogel through the covalent cross-linking of carboxymethyl cellulose (CMC) macromolecules, while incorporating one-dimensional cellulose nanofibers (CNF) and two-dimensional MXene as reinforcing network scaffolds and conductive fillers.

Silver-catalyzed P-centered anion nucleophilic addition to isocyanide: access to 2-phosphinoyl indoles/indol-3-ols.

A silver-catalyzed chemoselective cascade nucleophilic addition of a P-centered anion to isocyanides and cyclization reaction was developed for the efficient and practical synthesis of a wide range of 2-phosphinoyl indole and indol-3-ol derivatives. Unlike the well-documented synthesis of phosphorus-functionalized heterocycles a P-centered radical, an anionic reactivity profile of phosphine oxides is most likely involved in this domino transformation.

Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel.

Objective: This study aimed to investigate whether flow fluid shear stress (FFSS)-mediated signal transduction affects the function of Piezo1 ion channel in chondrocyte and to further explore the role of mechanical overloading in development of temporomandibular joint osteoarthritis (TMJ OA).

Methods: Immunohistochemical staining was used to determine the expression of Piezo1 in TMJ OA tissue collected from rat unilateral anterior crossbite (UAC) models. Chondrocytes harvested from normal adult SD rats were treated with FFSS (0, 4, 8, 12 dyn/cm) in vitro.

Access to 2-thio/selenoquinolines domino reaction of isocyanides with sulfur and selenium in water.

A domino reaction of -alkenylaryl isocyanides with elemental sulfur and selenium in pure water was developed for the efficient and green synthesis of quinoline-2-thione and diquinolyl diselenide derivatives. Mechanistical investigation reveals that intramolecular nucleophilic addition of an alkenyl group to the generated isothio/isoselenocyanate accounts for the formation of a quinoline-ring. Moreover, this transformation is also amendable for the convenient preparation of 2-fluoromethylthio-/seleno-quinolines by a one-pot three-component reaction.

A Flexible and Highly Sensitive Pressure Sense Electrode Based on Cotton Pulp for Wearable Electronics.

Flexible pressure sensors with high sensitivity have great potential applications in wearable electronics. However, it is still a great challenge to prepare sense electrodes with high flexibility, high sensitivity, and high electrochemical performance. Here, we propose a novel and simple method for carbonizing cotton fibers as excellent electrically conductive materials.

Association of HMGB1 levels in synovial fluid with the severity of temporomandibular joint osteoarthritis.

Background: HMGB1 usually serves as a damage-associated molecular pattern (DAMP) molecule (also known as alarmin) that regulates the inflammatory and immune responses via different receptors or direct uptake. Numerous studies have reported the association between HMGB1 and inflammatory diseases; however, its role in temporomandibular joint (TMJ) osteoarthritis (OA) has not been elucidated. In this retrospective study, we aimed to investigate HMGB1 levels in the synovial fluid (SF) in patients with TMJOA and TMID, their correlation with TMJOA and TMID severity, and the therapeutic effect of sodium hyaluronate (hyaluronic acid, HA) on TMJOA.

A Particleboard Surface Defect Detection Method Research Based on the Deep Learning Algorithm.

Particleboard surface defects have a significant impact on product quality. A surface defect detection method is essential to enhancing the quality of particleboard because the conventional defect detection method has low accuracy and efficiency. This paper proposes a YOLO v5-Seg-Lab-4 (You Only Look Once v5 Segmentation-Lab-4) model based on deep learning.

Immunohistochemical analysis of pyroptosis-related protein expression in IgG4-related sialadenitis.

Background: NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3)-induced pyroptosis is involved in the development of a variety of autoimmune diseases, but its role in IgG4-related sialadenitis (IgG4-RS) is unclear.

Methods: Salivary gland tissues from 19 patients with IgG4-RS were designated the experimental group, and peritumoral tissues from 20 patients with benign salivary gland tumours were designated the control group. The cell morphology and fibrosis in the IgG4-RS samples were observed by haematoxylin-eosin (H&E) and Masson trichrome (MT) staining.

The value of high-resolution MRI in the diagnosis, efficacy of treatment, and prognosis of central nervous system vasculitis.

Aim Of The Study: To explore the high-resolution magnetic resonance imaging (HR-MRI) characteristics of central nervous system (CNS) vasculitis and to explore the value of HR-MRI in the treatment effect and prognosis evaluation of CNS vasculitis.

Material And Methods: During the follow-up of 24 patients diagnosed as CNS vasculitis by the Second Hospital of Hebei Medical University, 3.0T HR-MRI was used for imaging examination and HR-MRI characteristics were analysed.

A comparative analysis of NLRP3-related inflammatory mediators in synovial fluid in temporomandibular joint osteoarthritis and internal derangement.

Background: The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome signaling pathway is a highlighted topic in the field of inflammation. However, there is little research on the relationship between the NLRP3 inflammasome pathway and temporomandibular joint osteoarthritis (TMJOA). The aim of this study was to examine the expression of inflammatory mediators related to the NLRP3 inflammasome in the synovial fluid of patients with condylar cartilage degeneration and verify the clinical effects of sodium hyaluronic acid (HA) treatment on TMJOA.

Biofunctional Extracellular Matrix-Polycaprolactone-Hydroxyapatite Scaffold and Synovium Mesenchymal Stem Cells/Chondrocytes for Repairing Cartilage Defects.

Articular cartilage defects and degeneration can be caused by multiple factors, and the current clinical treatment schemes for pathological changes are relatively limited. Engineered cartilage tissue represents an alternative therapy for repairing cartilage defects in regenerative medicine. The scaffold material is considered the framework of tissue engineering; thus, scaffold material selection plays a crucial role in the therapy outcome.

The effects of deposition time and current density on the electrochemical performance of flexible and high-performance MnO@PFG composite electrodes.

A novel composite electrode has been fabricated by the direct deposition of MnO onto graphene networks surrounding a paper fiber (PFG). The paper fiber between graphene sheets could be used as a flexible substrate for MnO nanoparticles, and the microscopic morphologies and electrochemical performances of the MnO@PFG electrodes were tuned regulating the deposition current densities and deposition times. 3D graphene on PFG served as a highly conductive backbone with a high surface area for the deposition of the MnO nanoparticles, which provided high accessibility to electrolyte ions for shortening the diffusion paths.

[Logistic regression analysis of risk factors of temporomandibular disorder in undergraduates of Xinjiang Medical University].

Purpose: To investigate the prevalence of temporomandibular disorders (TMD) in undergraduates of Xinjiang Medical University and analyse its possible risk factors.

Methods: A sample of 700 medical students included 244 males and 456 females was selected from Xinjiang Medical University and underwent examination of temporomandibular joint, questionnaire survey. Their average age was 20.

Self-assembly of flexible graphene hydrogel electrode based on crosslinked pectin-cations.

Pectin, natural polysaccharide biopolymer, was chelated with cations (Mg/Ca) to form an interwoven framework. Herein, the graphene hydrogel electrodes were self-assembled by the synergistic effects of pectin-cations. The optimum combination proportion was determined, the Mg/Ca-pectin matrix cross-linked graphene hydrogel (Mg/Ca-PGH) electrodes exhibited a large specific capacitance of about 839.

High-performance MnO-deposited graphene/activated carbon film electrodes for flexible solid-state supercapacitor.

High theoretical capacitance of MnO nanoparticles were successfully electrodeposited on the conductive graphene/activated carbon (GN/AC) composite film, and the urchin type MnO microspheres were controlled by adjusting the electro-deposition reaction times. The GN/AC/MnO-1200s composite electrodes exhibited a maximum specific capacitance of 1231 mF/cm (MnO loading mass of 7.65 mg/cm and the mass specific capacitance of 123 F/g) at a current density of 0.

Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.

The syntheses of inflammatory mediators are energy-intensive processes and the mitochondria play pivotal roles in supporting these energy-requiring molecular responses. In the present studies, a mitochondrial respiratory complex I inhibitor rotenone was administrated in mice with lipopolysaccharide/D-galactosamine (LPS/D-Gal)-induced fulminant liver injury and the prophylactic and therapeutic effects on tissue injury were evaluated. We found that pretreatment with rotenone suppressed the elevation of plasma aminotransferases, alleviated the histopathological abnormalities and improved the survival rate of LPS/D-Gal-challenged mice.

Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury.

Metformin is a commonly used anti-diabetic drug with AMP-activated protein kinase (AMPK)-dependent hypoglycemic activities. Recent studies have revealed its anti-inflammatory and anti-oxidative properties. In the present study, the anti-oxidative potential of metformin and its potential mechanisms were investigated in a mouse model with carbon tetrachloride (CCl₂)-induced severe oxidative liver injury.

Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury.

Garcinol is a polyisoprenylated benzophenone derivative of Garcinia indica. Recent researches have revealed the antioxidant, anticancer and anti-inflammatory properties of garcinol. In the present study, the pharmacological effects of garcinol in lipopolysaccharide (LPS)-induced hepatic injury in D-galactosamine (D-Gal)-sensitized mice were investigated.

Potential role of catalase in mice with lipopolysaccharide/D-galactosamine-induced fulminant liver injury.

Aim: Lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-Gal)-sensitized mice is a well-established animal model widely used in exploring the pathogenesis of fulminant hepatitis. Increasing evidence has indicated that reactive oxygen species (ROS)-induced oxidative injury may be involved in LPS/D-Gal-induced hepatitis. Catalase (CAT) is a major antioxidant enzyme while aminotriazole (ATZ) is commonly used as a CAT inhibitor.

Negative transcriptional regulation of inflammatory genes by group B3 vitamin nicotinamide.

The water-soluble group B3 vitamin nicotinamide (NAM) is involved in a wide range of physical processes through biosynthetically converted to nicotinamide adenine dinucleotide (NAD(+)). In addition to its pivotal role in energy metabolism, NAD(+) is also the indispensable substrate of poly (ADP-ribose) polymerase-1 (PARP-1) and sirtuin 1 (SIRT1). PARP-1 and SIRT1 may catalyze the posttranslational poly(ADP-ribosyl)ation and acetylation of histones as well as non-histone proteins, such as nuclear factor kappa B and activator protein 1, which play crucial roles in transcriptional regulation of inflammatory genes.

Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice.

Carbon tetrachloride (CCl(4)) has been used extensively to study xenobiotic-induced oxidative liver injury. Catalase (CAT) is a major antioxidant enzyme while aminotriazole (ATZ) is commonly used as a CAT inhibitor. In the present study, the effects of ATZ on CCl(4)-induced liver injury were investigated.