Customized Sized Manganese Sulfide Nanospheres as Efficient T MRI Contrast Agents for Enhanced Tumor Theranostics.

The impact of nanoparticle size on the effectiveness of magnetic resonance imaging (MRI) using sulfurized manganese nanoparticles (MnS@PAA) stabilized with polyacrylic acid (PAA) as a binder was thoroughly investigated. MnS@PAA nanoparticles of varying sizes were synthesized by altering the ratio of ethylene glycol (EG) to diethylene glycol (DEG) during the synthesis process. These nanoparticles exhibited a uniform size distribution and demonstrated high T relaxation rates, along with a notable pH-responsive behavior.

Efficient enrichment and sensitive detection of polychlorinated biphenyls using nanoflower MIL-on-UiO as solid-phase microextraction fiber coating.

The sensitive detection of polychlorinated biphenyls (PCBs) is crucial for protecting the environment and human health. Herein, we constructed a Materials Institute Lavoisier 88B (MIL-88B)-on-University of Oslo 66 (UiO-66) composite (MIL-on-UiO) with a unique nanoflower morphology, in which highly stable UiO-66 is the precursor, with MIL-88B grown on its surface. MIL-on-UiO was used as a fiber coating for headspace solid-phase microextraction to enrich PCBs.

Platinum Nanoparticles-Enhanced Ferritin-Mn Interaction for Magnetic Resonance Contrast Enhancement and Efficient Tumor Photothermal Therapy.

Nanoplatforms with high Mn coordination can display efficient T magnetic resonance imaging (MRI) contrast enhancement. Herein, an earth gravity-like method for enhanced interaction between Ferritin (Fn) and Mn by the growth of platinum nanoparticles (PNs) in Fn's cage structure via a biomineralization method is first proposed. Fn has good biocompatibility and can provide a suitable growth site for PNs.

Polydopamine Nanostructure-Enhanced Water Interaction with pH-Responsive Manganese Sulfide Nanoclusters for Tumor Magnetic Resonance Contrast Enhancement and Synergistic Ferroptosis-Photothermal Therapy.

Rational structure design benefits the development of efficient nanoplatforms for tumor theranostic application. In this work, a multifunctional polydopamine (PDA)-coated manganese sulfide (MnS) nanocluster was prepared. The polyhydroxy structure of PDA enhanced the water interaction with pH-responsive MnS nanoclusters via hydrogen bonds.

Three-dimensional rose-like zinc oxide fiber coating for simultaneous extraction of polychlorinated biphenyls and polycyclic aromatic hydrocarbons by headspace solid phase microextraction.

The three-dimensional (3D) rose-like zinc oxide (ZnO) material was prepared by a simple one-step CTAB-assisted hydrothermal strategy and used as a headspace solid-phase microextraction (HS-SPME) coating. Polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) were analyzed by gas chromatography with flame ionization detector (GC-FID), and conclusively applied to ultrasensitive detection in lake and river water. Compared with one-dimensional (1D) pencil-like ZnO, the layer-by-layer petal-like structure could fully expose mass adsorption sites on the surface, which could significantly improve the adsorption.

Ionic liquid-modified UiO-66-NH as sorbent of dispersive solid-phase extraction for rapid adsorption and enrichment of benzoylurea insecticides.

Ionic liquid (IL)-modified UiO-66-NH composite was prepared and used as sorbent of dispersed solid-phase extraction (dSPE) for extracting trace benzoylurea insecticides (BUs) from complex environmental matrices. The IL in framework endowed the prepared material had electropositive characteristics, which can produce interaction with electron rich guest molecules, such as BUs. The high thermal and chemical stability of UiO-66-NH/IL enabled it to be reused for 16 times without significant reduction in adsorption performance.

Well-defined FeO@MIL-100(Fe) hollow nanoflower heterostructures for selective dection and monitoring of benzoylurea insecticides from food and water.

Developing a platform for the selective detection and effective monitor of toxic contaminants is a major challenge to address organic contaminants contamination in environmental science. Here, for the first time, the thickness-controllable FeO@MIL-100(Fe) heterogeneous materials with special hollow nanoflower (HFs) morphology had been synthesized. The morphology and shell thickness of the nano-petal could be tuned by changing the reaction time.

Confinement effect of ionic liquid: Improve of the extraction performance of parent metal organic framework for phthalates.

In order to better identify the hazards of pollutants, developing the analytical methods that can sensitively detect and precisely monitor the content of trace pollutants has been the constant pursuit. In this paper, a new solid phase microextraction coating-ionic liquid/metal organic framework (IL/MOF) was obtained through the IL-induced strategy and used for the solid phase microextraction (SPME) process. IL was introduced into metal-organic framework (MOF) cage based on the anion of ionic liquid could interact strongly with the zirconium nodes of UiO-66-NH.

Construction of hierarchically porous metal-organic framework HP-UiO-66-30% for sensitive determination of benzoylurea insecticides.

Due to widespread application of benzoylurea insecticides (BUs) and its persistence in environment, the effective capture of benzoylurea insecticides residues in environment is an important issue of environmental safety monitoring. To obtain excellent adsorption performance, creating defective structure in metal-organic frameworks (MOFs) can be employed as the method for adjusting its properties. Zirconium(Ⅳ)-based MOF termed as UiO-66-30% was constructed with 2-aminoterephthalic acid (NH-BDC) and terephthalic acid (HBDC) as building blocks.

Synthesis of spindle-like amino-modified Zn/Fe bimetallic metal-organic frameworks as sorbents for dispersive solid-phase extraction and preconcentration of phytohormoes in vegetable samples.

Amino-modified Zn/Fe bimetallic metal-organic frameworks (NH-Zn/Fe-MIL-88) were synthesized using a one-step solvothermal method with FeCl·6HO and Zn(NO)·6HO as metal salts and 2-aminoterephthalic acid as organic ligand. The morphology of NH-Zn/Fe-MIL-88 can be regulated from octahedral-like to spindle-like with changing molar ratios of metal salts. Using NH-Zn/Fe-MIL-88 as sorbent, a dispersive solid-phase extraction with putting sorbents into sample solution to extract targets was developed to preconcentrate phytohormones in vegetables.

Poly(divinylbenzene) as a fiber coating for headspace solid-phase microextraction of polycyclic aromatic hydrocarbons from river water.

Porous polydivinylbenzene microspheres with high specific surface area were prepared by distillation-precipitation polymerization, and were used as the coating material in headspace solid phase microextraction for extracting polycyclic aromatic hydrocarbons. Compared with the other reported sorbents, PDVB exhibits lower cost and higher extraction efficiency, and the enrichment factors can reach 5963-16 720.

Porous Hexagonal Boron Nitride as Solid-Phase Microextraction Coating Material for Extraction and Preconcentration of Polycyclic Aromatic Hydrocarbons from Soil Sample.

Sample pretreatment plays important role in the analysis and detection of trace pollutants in complex matrices, such as environmental and biological samples. The adsorption materials of sample pretreatment receive considerable attention, which has a significant effect on the sensitivity and selectivity of the analytical method. In this work, the porous hexagonal boron nitride (h-BN) was utilized as a coating material of solid-phase microextraction (SPME) to extract and preconcentrate polycyclic aromatic hydrocarbons (PAHs) prior to separation and detection with GC-FID.

Arsenic (III) induces oxidative stress and inflammation in the gills of common carp, which is ameliorated by zinc (II).

Arsenic (As) is widely present in the environment in form of arsenite (As) and arsenate (As). Oxidative stress and inflammation are believed to be the dominant mechanisms of As toxicity in vivo and in vitro. The aim of this study was to investigate whether zinc (Zn) alleviates exogenous gill toxicity in carp induced by As and to gain insight into the underlying mechanisms.

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production.

As a group of cytokines, interferons are the first line of defense in the antiviral immunity. In this study, Siberian tiger IFN-β (PtIFN-β) and IFN-γ (PtIFN-γ) were successfully amplified, and the two were fused (PtIFN-γ) by overlap extension polymerase chain reaction (SOE-PCR). Bioinformatics analysis disclosed that PtIFN-β and PtIFN-γ have species-specificity and conservation in the course of evolution.

Zinc offers splenic protection through suppressing PERK/IRE1-driven apoptosis pathway in common carp (Cyprinus carpio) under arsenic stress.

Arsenic (As) occurs naturally and concentrations in water bodies can reach high levels, leading to accumulation in vital organs like the spleen. Being an important organ in immune response and blood development processes, toxic effects of As on the spleen could compromise immunity and cause associated disorders in affected individuals. Splenic detoxification is key to improving the chances of survival but relatively little is known about the mechanisms involved.

Lycopene alleviates sulfamethoxazole-induced hepatotoxicity in grass carp () suppression of oxidative stress, inflammation and apoptosis.

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health. However, the toxicity of antibiotics on aquatic organisms, especially the effects on the detoxification system and immune system, has not been thoroughly studied. Lycopene (LYC) is a naturally occurring hydrocarbon carotenoid, which has received extensive attention as a potential antioxidant.

Arsenic (III) and/or copper (II) induces oxidative stress in chicken brain and subsequent effects on mitochondrial homeostasis and autophagy.

As two quite complicated substances, arsenic (As) and copper (Cu) have polluted to the environment. As is highly toxic and could cause nerve damage. Cu is involved in the occurrence of oxidative stress.

Grass carps co-exposed to environmentally relevant concentrations of cypermethrin and sulfamethoxazole bear immunodeficiency and are vulnerable to subsequent Aeromonas hydrophila infection.

The aquatic ecosystem is seriously damaged because of the heavy use of pesticides and antibiotics. Fish is the indispensable link between environmental pollution and human health. However, the toxic effects of environment-related concentrations of pesticides and antibiotics in fish have not been thoroughly studied.

Oxidative damage under As and/or Cu stress leads to apoptosis and autophagy and may be cross-talking with mitochondrial disorders in bursa of Fabricius.

Arsenic (As) exists in many forms in the whole natural environment, with As the highest toxicity. Herein our study demonstrated that arsenic trioxide (AsO) at a dose of 30 mg/kg caused serious oxidative damage to chickens' bursa of Fabricius (BF) in a time-dependent manner. Copper (Cu) is a necessary micronutrient and a key catalytic cofactor of many enzymes.

Arsenic (III) or/and copper (II) exposure induce immunotoxicity through trigger oxidative stress, inflammation and immune imbalance in the bursa of chicken.

The environmental hazards of arsenic (As) and copper (Cu) contamination have swept through quite a few districts worldwide. Whereas, molecular mechanisms involved in As- and Cu-induced immunotoxicity in Gallus gallus bursa of Fabricius (BF) are complex and elusive. Male Hy-line chickens were exposed to arsenic trioxide (AsO; 30 mg/kg) and copper sulfate (CuSO; 300 mg/kg) alone or in combination, respectively, to examine the potential ecotoxicity of them.

Elemental imbalance elicited by arsenic and copper exposures leads to oxidative stress and immunotoxicity in chicken gizzard, activating the protective effects of heat shock proteins.

Arsenic (As) and copper (Cu) are ubiquitous pollutants that pose a threat to the environment. Our aim is to study the underlying mechanisms by which As and Cu act on the chicken gizzard. In order to detect ionic disorders in chicken gizzard under chronic treatment with As and/or Cu and whether they can induce oxidative damage as well as immune disorders, 30 mg/kg arsenic trioxide (AsO) and/or 300 mg/kg copper sulfate (CuSO) were added to the chicken's basal diet.

Zinc alleviates arsenism in common carp: Varied change profiles of cytokines and tight junction proteins among two intestinal segments.

This study was designed to evaluate the effects of zinc on inflammation and tight junction (TJ) in different intestinal regions of common carp under sub-chronic arsenic insult. Fish were exposed to zinc (0, 1 mg/L) and arsenic trioxide (0, 2.83 mg/L) in individual or combination for a month.

Arsenic trioxide or/and copper sulfate co-exposure induce glandular stomach of chicken injury via destruction of the mitochondrial dynamics and activation of apoptosis as well as autophagy.

Arsenic and copper are naturally occurring element. Contamination from natural processes and anthropogenic activities can be discovered all over the world and their unique interactions with the environment lead to widespread toxicity. When the content was excessive, the organism would be hurt seriously.

Hepatoprotective effects of zinc (II) via cytochrome P-450/reactive oxygen species and canonical apoptosis pathways after arsenite waterborne exposure in common carp.

Chronic arsenicosis has threatened the survival of aquatic animals with molecular mechanisms yet clear. In the present study, liver damage was evident by fluctuated activities of transaminases and declined ATPases in common carp under arsenic (As) exposure for 30 days. Mechanically, As significantly decreased cytochrome P-1A (CYP1A) activity and increased reactive oxygen species (ROS) content, which corroborated mitochondrial dysfunction in the hepatocytes.

Excessive Cu deteriorates arsenite-induced apoptosis in chicken brain and resulting in immunosuppression, not in homeostasis.

Trace elements such as copper (Cu) and arsenic (As) are two of the major contaminants and well-known inducers of cognitive deficits and neurobehavioral changes. This study evaluated the immunotoxicity of their individual or combined exposure on different brain regions in chickens. Consequently, nuclear damage and organelle lesions, especially mitochondria were observed under Cu or/and As stress, in which positive regulation of key proteins, dynamin-related protein 1 (Drp1), Cytochrome C (Cyt c), BCL2-associated X (Bax), Caspases 3 and P53 was detected by qRCR and Western blot analyses, indicating disturbed mitochondrial dynamic equilibrium and apoptosis execution.