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Publications by authors named "Mengyan Tao"

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Recombinant parainfluenza virus 5 expressing clade 2.3.4.4b H5 hemagglutinin protein confers broad protection against H5Ny influenza viruses.
Han Li Haoran Sun Mengyan Tao Qiqi Han Haili Yu Litao Liu

J Virol

March 2024

Article Synopsis
  • The study addresses the public health threat posed by clade 2.3.4.4b H5Ny highly pathogenic avian influenza viruses (HPAIVs), emphasizing the need for effective vaccines to prepare for potential pandemics.
  • Researchers developed a parainfluenza virus 5 (PIV5)-based vaccine candidate, named rPIV5-H5, which showed safety and efficacy in stimulating immune responses in mice and ferrets.
  • The rPIV5-H5 vaccine provided complete protection against lethal infections from various H5N1 virus clades, indicating its potential as a pan-H5 influenza vaccine for emergency use.
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