Clinical features of anti-ribosomal P protein antibodies in systemic lupus erythematosus: A single-center retrospective study in China.

Objectives: To investigate the clinical characteristics of patients with systemic lupus erythematosus (SLE) with positive anti-ribosomal P protein antibodies and the associated risk factors in a larger sample size.

Methods: A single-center, retrospective study was conducted. Based on the medical records of in-patients from June 2009 to December 2022, patients with SLE were divided into anti-ribosomal P protein antibody-positive and negative groups according to a 1:3 gender and age match.

Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus.

Japanese encephalitis virus (JEV) is a neurotropic zoonotic pathogen that poses a serious threat to public health. Currently, there is no specific therapeutic agent available for JEV infection, primarily due to the complexity of its infection mechanism and pathogenesis. Extracellular vesicles (EVs) have been known to play an important role in viral infection, but their specific functions in JEV infection remain unknown.

Two novel compounds inhibit Flavivirus infection and by targeting lipid metabolism.

Unlabelled: Flavivirus infection capitalizes on cellular lipid metabolism to remodel the cellular intima, creating a specialized lipid environment conducive to viral replication, assembly, and release. The Japanese encephalitis virus (JEV), a member of the genus, is responsible for significant morbidity and mortality in both humans and animals. Currently, there are no effective antiviral drugs available to combat JEV infection.

Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study.

Objectives: This study aimed to evaluate the clinical value of the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) for assessing disease activity in patients with SLE.

Methods: Clinical data were collected from patients with SLE who were admitted at the Second Affiliated Hospital of Soochow University from January 2009 to December 2022. The glucocorticoid dose grading was used as the gold standard for disease activity assessment in SLE.

Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence.

In flavivirus, the furin-mediated cleavage of prM is mandatory to produce infectious particles, and the immature particles containing uncleaved prM cannot undergo membrane fusion and release to the extracellular environment. However, the detailed relationship between viral replication or pathogenicity and furin in Japanese encephalitis virus (JEV) hasn't been clarified. Here, JEV with the mutations in furin cleavage sites and its nearby were constructed.

Effects of biochar on soil microbial community and functional genes of a landfill cover three years after ecological restoration.

Landfills, as the most common approach to disposing of municipal solid waste worldwide, disturb native ecosystems and create a need for ecological restoration. The restoration of landfill cover with biochar has shown immediate potential to improve soil microbial functions within one year. However, such characteristics could change after a longer period of time.

Synergistic Effect and Characterization of Graphene/Carbon Nanotubes/Polyvinyl Alcohol/Sodium Alginate Nanofibrous Membranes Formed Using Continuous Needleless Dynamic Linear Electrospinning.

In this study, a self-made continuous needleless dynamic linear electrospinning technique is employed to fabricate large-scale graphene (Gr)/carbon nanotubes (CNT)/polyvinyl alcohol (PVA)/sodium alginate (SA) nanofibrous membranes. The synergistic effect of Gr and CNT fillers in the PVA/SA membrane is explored in depth by changing the volume ratio (/) of Gr and CNT as 10:0, 8:2, 6:4, 4:6, 2:8, and 0:10. Microstructure, functional group, conductivity, and hydrophilicity of PVA/SA/Gr/CNT membranes was characterized.

Mass-Production and Characterizations of Polyvinyl Alcohol/Sodium Alginate/Graphene Porous Nanofiber Membranes Using Needleless Dynamic Linear Electrospinning.

The aim of this study was to investigate the feasibility of large-scale preparation of porous polyvinyl alcohol/sodium alginate/graphene (Gr) (Gr-AP) nanofiber membranes using a copper wire needleless dynamic linear electrode electrospinning machine. Furthermore, the effects of Gr concentrations (0, 0.0375, 0.

Characterization and Microstructure of Linear Electrode-Electrospun Graphene-Filled Polyvinyl Alcohol Nanofiber Films.

With the aim of achieving controllable mass production of electrospun nanofiber films, this study proposes and investigates the feasibility of using a custom-made linear electrode- electrospun device to produce conductive graphene (GR)-filled polyvinyl alcohol (PVA) nanofibers. The film morphology and diameter of nanofibers are observed and measured to examine the effects of viscosity and conductivity of the PVA/GR mixtures. Likewise, the influence of the content of graphene on the hydrophilicity, electrical conductivity, electromagnetic interference shielding effectiveness (EMSE), and thermal stability of the PVA/GR nanofiber films is investigated.