Embedded Spatial-Temporal Convolutional Neural Network Based on Scattered Light Signals for Fire and Interferential Aerosol Classification.

Photoelectric smoke detectors are the most cost-effective devices for very early warning fire alarms. However, due to the different light intensity response values of different kinds of fire smoke and interference from interferential aerosols, they have a high false-alarm rate, which limits their popularity in Chinese homes. To address these issues, an embedded spatial-temporal convolutional neural network (EST-CNN) model is proposed for real fire smoke identification and aerosol (fire smoke and interferential aerosols) classification.

Aerosol Sauter mean diameter measurement based on the light scattering response of the combined particle volume-surface area.

The relationship between the numerical of Sauter mean diameter (SMD) and aerosol distribution parameters, as well as its physical significance are lacking in detailed research. Meanwhile, existing method is not widely used for SMD accurate measurement due to many restrictions on the incident light wavelengths. In this study, we analyzed the relationship between SMDs and the mean and median values of the lognormal, normal, and Weibull distributions with different parameters.

Calcium Overload or Underload? The Effects of Doxorubicin on the Calcium Dynamics in Guinea Pig Hearts.

The severe doxorubicin (DOXO) side effect of cardiomyopathy limits it clinical application as an effective anticancer drug. Although Ca overload was postulated as one of the mechanisms for this toxicity, its role was, however, disputable in terms of the contractile dysfunction. In this work, the dynamics of the intracellular Ca signal were optically mapped in a Langendorff guinea pig heart.

Modification, Biological Evaluation and SAR Studies of Novel 1H-Pyrazol Derivatives Containing N,N'-Disubstituted Urea Moiety as Potential Anti-melanoma Agents.

Malignant melanomas are amongst the most aggressive cancers. BRAF Inhibitors have exhibited therapeutic effects against BRAF-mutant melanoma. In continuation of our earlier studies on anti-melanoma agents based on 1H-pyrazole skeleton, two sets of novel compounds that include 1H-pyrazole-4-amines FA1 - FA13 and corresponding urea derivatives FN1 - FN13 have been synthesized and evaluated for their BRAF inhibitory and antiproliferation activities.

A Review of the Components of Seaweeds as Potential Candidates in Cancer Therapy.

The marine natural products (MNPs) isolated from seaweeds-associated microbial communities have received substantial attention owing to their exceptional nutritional and pharmacology application, such as antiviral, anticancer, antiprotozoal, antifungal, and antibacterial properties and so on. Particularly, there are several MNPs that have been displayed attractive value for the development of novel anticancer agents. This review covers the literature published in the recent 5 years on the novel anticancer MNPs discovered originating from seaweeds, and focused on the chemistry and relative anticancer activities of new MNPs which categorize their source organisms.