A Study on the Liquid Helium Temperature Tensile Property of Fe-21Cr-15Ni-5Mn-2Mo Austenitic Stainless Steel after Solution Treatment.

A novel non-magnetic Fe-21Cr-15Ni-5Mn-2Mo austenitic stainless steel with high strength and plasticity has been developed. The microstructure and liquid helium temperature (4.2 K) tensile properties of the top and bottom samples of large-size forged flat steel after solution treatment at 1090 °C were investigated.

Reducing Cholesterol Level in Live Macrophages Improves Delivery Performance by Enhancing Blood Shear Stress Adaptation.

In recent years, live-cell-based drug delivery systems have gained considerable attention. However, shear stress, which accompanies blood flow, may cause cell death and weaken the delivery performance. In this study, we found that reducing cholesterol in macrophage plasma membranes enhanced their tumor targeting ability by more than 2-fold.

How nurses contribute to the elimination of hepatitis B? A systematic review and meta-analysis.

Background: With approximately one-third of the global population exhibiting serological evidence of exposure, the hepatitis B virus remains a serious public health threat. Elimination of hepatitis B faces enormous challenges, from prevention to diagnosis, treatment, and long-term monitoring. Nurses are pivotal in optimising the hepatitis B care continuum; however, their contributions have been neglected.

An investigation of the growth status of 19-year-old 'Yuji' plantation forest in the mountainous region of Henan, China.

Plantation forests play an important role in the mitigation of greenhouse gas emissions. Maxim is an emerging woody oil tree species in most Asian countries. The 19-year-old 'Yuji' plantation forest was selected as a sample site.

Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor.

The cuproptosis cell death pathway brings fresh opportunities for tumor therapy. However, efficient and targeted cuproptosis induction in tumors is still a challenge. Unfortunately, the well-known cuproptosis initiator, disulfiram and copper complex (DSF/Cu), also increases PD-L1 level in tumors, which may diminish the final therapeutic outcome.

Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy.

Biological membranes often play important functional roles in biomimetic drug delivery systems. We discover that the circulation time and targeting capability of biological membrane coated nanovehicles can be significantly improved by reducing cholesterol level in the coating membrane. A proof-of-concept system using cholesterol-reduced and PD-1-overexpressed T cell membrane to deliver a photothermal agent and a STING agonist is thus fabricated.

Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions.

Tissue adhesions could occur following surgeries, and severe tissue adhesions can lead to serious complications. Medical hydrogels could be applied at surgical sites as a physical barrier to prevent tissue adhesion. For practical reasons, spreadable, degradable, and self-healable gels are highly demanded.

Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment.

Photothermal therapy (PTT) was reported to induce synergistic immunogenic cell death (ICD) which may convert tumor cells into "therapeutic vaccines". However, this is often insufficient to prevent tumor recurrence, in part because of the immunosuppressive microenvironment in tumors. Therefore, remodeling tumor microenvironment is of great importance to enhance the therapeutic efficacy of PTT.

Effect of Yttrium on the Microstructure and Mechanical Properties of PH13-8Mo Stainless Steels Produced by Selective Laser Melting.

In the present work, PH13-8Mo stainless steel parts without yttrium and with yttrium (Y) were manufactured by selective laser melting (SLM). The microstructure, phase composition and grain orientation of the stainless steels parts with Y and without Y were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), electron-backscatter diffraction (EBSD), transmission electron microscopy (TEM) and high-resolution transmission electron microscopy (HRTEM). The characterization results revealed that the addition of Y clearly refined the grain size of the PH13-8Mo steel formed part, resulting in more equiaxed massive grains and in a less anisotropic microstructure.

CH/π-interaction-driven self-assembly of tetraphenylethylene derivatives into the face to face arrangement.

For tetraphenylethene (TPE) derivatives, it is difficult to determine the arrangement of the molecules in the aggregation state because disordered aggregation usually occurs. To solve the problem, we have explored a novel and facile strategy to investigate the aggregation mode of a TPE derivative framework in which the two neighboring carbons of two phenyl moieties at the same ethylene carbon were linked with an alkoxyl chain (C4) (denoted as TPEC4). The XRD measurements on the particles obtained in a DMSO/HO mixture ( = 60%) showed sharp peaks which is consistent with the simulated XRD patterns on the basis of a single crystal structure of TPEC4, indicating well-ordered molecular packing in the aggregated state.

Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.

Objective: To analyze clinical studies on correlations between Traditional Chinese Medicine (TCM) body constitution types and diseases published in the past 10 years, and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.

Methods: We searched five databases for the period April 2009 to December 2019: China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, PubMed and Embase. Three types of observational studies on correlation between constitution types and diseases were included: cross-sectional, case-control and cohort studies.

Tuning the fluorescence based on the combination of TICT and AIE emission of a tetraphenylethylene with D-π-A structure.

A simple D-π-A structured tetraphenylethylene with two electron-rich methyloxy groups and two electron withdrawing cyano groups, which features both twisted intramolecular charge-transfer (TICT) and aggregation-induced emission (AIE) properties, namely TPEOMeCN has been prepared. The emission of TPEOMeCN examined in various solvents is dependent on the polarities of solvents, which indicates the TICT character. The emission intensity of the compound also enhances with the increasing water fraction in HO-DMSO mixtures, demonstrating the typical AIE property.

Quality appraisal of gestational diabetes mellitus guidelines with AGREE II: a systematic review.

Background: Several societies and associations have produced and disseminated clinical practice guidelines (CPGs) for gestational diabetes mellitus (GDM). However, the quality of such guidelines has not been appraised so far. This study aims to evaluate the quality of CPGs for GDM published in the last decade using the AGREE II instrument.

Current guidelines on the management of gestational diabetes mellitus: a content analysis and appraisal.

Background: Despite many guidelines for the management of gestational diabetes available internationally, little work has been done to summarize and assess the content of existing guidelines. A paucity of analysis guidelines within in a unified system may be one explanatory factor. So this study aims to analyze and evaluate the contents of all available guidelines for the management of gestational diabetes.

Regulating the emission of tetraphenylethenes by changing the alkoxyl linkage length between two neighboring phenyl moieties.

Alkoxyl linkages with different carbon lengths are employed to link the two neighboring ortho carbons of the two phenyl moieties at the same ethylene carbon of the tetraphenylethene framework, resulting in successful regulation of the molecular conformation and in turn the emission properties.

3D Nitrogen-Anion-Decorated Nickel Sulfides for Highly Efficient Overall Water Splitting.

Developing non-noble-metal electrocatalysts with high activity and low cost for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is of paramount importance for improving the generation of H fuel by electrocatalytic water-splitting. This study puts forward a new N-anion-decorated Ni S material synthesized by a simple one-step calcination route, acting as a superior bifunctional electrocatalyst for the OER/HER for the first time. The introduction of N anions significantly modifies the morphology and electronic structure of Ni S , bringing high surface active sites exposure, enhanced electrical conductivity, optimal HER Gibbs free-energy (ΔG ), and water adsorption energy change (ΔG ).

Regulating Water-Reduction Kinetics in Cobalt Phosphide for Enhancing HER Catalytic Activity in Alkaline Solution.

Electrochemical water splitting to produce hydrogen renders a promising pathway for renewable energy storage. Considering limited electrocatalysts have good oxygen-evolution reaction (OER) catalytic activity in acid solution while numerous economical materials show excellent OER catalytic performance in alkaline solution, developing new strategies that enhance the alkaline hydrogen-evolution reaction (HER) catalytic activity of cost-effective catalysts is highly desirable for achieving highly efficient overall water splitting. Herein, it is demonstrated that synergistic regulation of water dissociation and optimization of hydrogen adsorption free energy on electrocatalysts can significantly promote alkaline HER catalysis.