. Major depressive disorder (MDD) is a prevalent psychiatric disorder whose diagnosis relies on experienced psychiatrists, resulting in a low diagnosis rate. As a typical physiological signal, electroencephalography (EEG) has indicated a strong association with human beings' mental activities and can be served as an objective biomarker for diagnosing MDD.
View Article and Find Full Text PDFThe concept of the inflammatory pre-metastatic niche (PMN) provides a new and promising direction for the prevention and treatment of metastasis. The excessive activation of the GAS-STING signaling leads to augmented metastasis by promoting the formation of the inflammatory PMN. In this study, tumor-derived microparticles (MP) were used to establish the PMN model both in vitro and in vivo, and pro-inflammatory mediators were also employed to evaluate the effects of Icaritin (ICT).
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