CircGSK3β mediates PD-L1 transcription through miR-338-3p/PRMT5/H3K4me3 to promote breast cancer cell immune evasion and tumor progression.

Circular RNA (circRNA) plays a pivotal role in breast cancer onset and progression. Understanding the biological functions and underlying molecular mechanisms of dysregulated circRNAs in breast cancer is crucial for elucidating its pathogenesis and identifying potential therapeutic targets. In this study, we investigated the role and molecular mechanism of circGSK3β in breast cancer.

Using multi-omics to explore the effect of Bacillus velezensis SAAS-63 on resisting nutrient stress in lettuce.

To avoid the unreasonable use of chemical fertilizer, an environmentally friendly means of improving soil fertility is required. This study explored the role of the plant growth-promoting rhizosphere bacteria (PGPR) strain Bacillus velezensis SAAS-63 in improving nutrient stress in lettuce. Compared with no inoculation, B.

HMGB1/RAGE axis in tumor development: unraveling its significance.

High mobility group protein 1 (HMGB1) plays a complex role in tumor biology. When released into the extracellular space, it binds to the receptor for advanced glycation end products (RAGE) located on the cell membrane, playing an important role in tumor development by regulating a number of biological processes and signal pathways. In this review, we outline the multifaceted functions of the HMGB1/RAGE axis, which encompasses tumor cell proliferation, apoptosis, autophagy, metastasis, and angiogenesis.

Precursor-directed production of water-soluble red pigments with high thermal stability via azaphilic addition reaction-based semi-synthesis.

Red pigments (MPs) are a large group of polyketides from the fungus which have been widely used as food colorants. In this study, a variety of red MPs congeners were prepared to explore promising water-soluble candidates for application in liquid food formulations. The results showed that by combining the two-stage, low-pH fermentation strategy with a downstream purification step of fractional crystallization, precursors of red MPs, namely monascorubrin and rubropunctatin, were obtained with a purity of 91.

Purification of Polysaccharide Produced by the Haploid Yeast Strain of and Its Antioxidant and Prebiotic Activities.

is a traditional Chinese medicinal and edible mushroom. Polysaccharides from mushrooms have received increasing amounts of research attention due to their diverse pharmacological activities. In this study, via the incubation of basidiospores collected from fresh artificially cultivated basidiocarps of , a haploid yeast strain of was obtained, and it was found to be a typical loose-slime-forming yeast capable of producing a large amount of exopolysaccharides (EPS).

YWHAH activates the HMGA1/PI3K/AKT/mTOR signaling pathway by positively regulating Fra-1 to affect the proliferation of gastric cancer cells.

Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development.

Role of histone H3K4 methyltransferase in regulating Monascus pigments production by red light-coupled magnetic field.

Light, magnetic field, and methylation affected the growth and secondary metabolism of fungi. The regulation effect of the three factors on the growth and Monascus pigments (MPs) synthesis of Monascus purpureus was investigated in this study. 5-azacytidine (5-AzaC), DNA methylation inhibitor, was used to treat M.

Role and mechanism of CD90 fibroblasts in inflammatory diseases and malignant tumors.

Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast subpopulations play different roles. A subpopulation of fibroblasts expressing CD90, a 25-37 kDa glycosylphosphatidylinositol anchored protein, plays a dominant role in the fibrotic and pro-inflammatory state. In this review, we focused on CD90 fibroblasts, and their roles and possible mechanisms in disease processes.

Effect of enzymatic hydrolysis on volatile flavor compounds of Monascus-fermented tartary buckwheat based on headspace gas chromatography-ion mobility spectrometry.

Tartary buckwheat was hydrolyzed with α-amylase, pullulanase, α-amylase and pullulanase double enzymes and fermented by Monascus. The fermentation products were named as enzymolysis-Monascus-fermented tartary buckwheat (EMFTB). The composition and content of volatile flavor compounds in EMFTB were investigated.

NMNAT2: An important metabolic enzyme affecting the disease progression.

Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is an evolutionarily conserved nicotinamide adenine dinucleotide (NAD) synthase located in the cytoplasm and Golgi apparatus. NMNAT2 has an important role in neurodegenerative diseases, malignant tumors, and other diseases that seriously endanger human health. NMNAT2 exerts a neuroprotective function through its NAD synthase activity and chaperone function.

Lactic acid bacteria synergistic fermentation affects the flavor and texture of bread.

Fermentation strains play a key role in the quality of bread. The combination of yeast and lactic acid bacteria (LAB) may effectively improve the function and nutritional properties of bread. In this study, the dough was fermented to make bread by using single strain (Saccharomyces cerevisiae, mode A), the combination of two strains (S.

A facile macroporous resin-based method for separation of yellow and orange pigments.

The yellow pigments (YMPs) named monascin and ankaflavin and the orange pigments (OMPs) named rubropunctatin and monascorubrin are two groups of bioactive components in a mixture state in the fermented products. In order to separate these two groups of bioactive pigments, a facile macroporous resin-based method was developed. The weak-polar resin CAD-40 was selected from the seven tested macroporous resins as it revealed better properties for the adsorption and desorption of the YMPs and OMPs.

Mutational analysis of MpPhy reveals magnetoreception and photosensitivity involvement in secondary metabolites biosynthesis in Monascus purpureus.

Light or low frequency magnetic field (LF-MF) as one of the cultivation environments affects secondary metabolites (SMs) production of M. purpureus. Phytochrome (Phy) is a hybrid histidine kinase possessing dual properties of photoreceptor and kinase to sense red and far-red light.

Fra-1 Inhibits Cell Growth and the Warburg Effect in Cervical Cancer Cells via STAT1 Regulation of the p53 Signaling Pathway.

The oncogenesis of cervical cancer is a multi-factor and multi-step process, and major risk factors include oncogene activation with tumor suppressor gene inactivation, viral factors, and immune factors. For example, the human papillomavirus (HPV) has been linked to the occurrence of cervical cancer. At present, the pathogenesis of cervical cancer remains unclear.

Lack of the Histone Methyltransferase Gene Ash2 Results in the Loss of Citrinin Production in Monascus purpureus.

Abstract: Absent, small, or homeotic discs 2 (Ash2), a histone H3K4 methyltransferase complex, has been implicated in the control of hyphal development and secondary metabolism in many kinds of filamentous fungi. We constructed an Ash2 deletion mutant (ΔAsh2) by using an Agrobacterium-mediated gene knockout method to investigate the function of the Ash2 gene in the mold Monascus purpureus. Lack of the Ash2 gene resulted in the formation of a lower colony phenotype with fluffy aerial hyphae that autolyzed as the colony grew on potato dextrose agar at 30°C.

Low-Frequency Magnetic Field of Appropriate Strengths Changed Secondary Metabolite Production and Na Concentration of Intracellular and Extracellular Monascus purpureus.

Monascus purpureus is used to yield edible pigments accompanied by mycotoxin-citrinin. A low-frequency (<300 Hz) magnetic field (LF-MF) affects microbial metabolism. The link of LF-MF with secondary metabolites and intracellular and extracellular Na levels in M.

Acidic conditions induce the accumulation of orange Monascus pigments during liquid-state fermentation of Monascus ruber M7.

The influence of pH on the biosynthesis of orange Monascus pigments (OMPs) in Monascus ruber M7 was investigated. Under acidic fermentation conditions, pigment mixtures predominantly rich in OMPs were obtained. HPLC analysis revealed the presence of four orange components (O1-O4) and four yellow components (Y1-Y4) in the mixtures, and the dominant ones were O1 and O3, which accounted for 56.

Photonic-based microwave hybrid combiner with arbitrarily tunable phase shift and power combining ratio.

We report a broadband photonic-based microwave hybrid combiner (PMHC) using a dual-polarization dual-parallel Mach-Zehnder modulator. The broadband PMHC with arbitrarily tunable phase shift and power combining ratio can overcome several limitations of conventional microwave combiners in terms of tunability and bandwidth. By simply adjusting the biases of the modulator, the phase shift and power ratio of the two combined microwave signals are independently, continuously, and freely tunable.

Correction: Zhen, Z. et al. NaCl Inhibits Citrinin and Stimulates Monascus Pigments and Monacolin K Production. Toxins 2019, 11, 118.

The authors wish to make the following correction to their paper [...

NaCl Inhibits Citrinin and Stimulates Pigments and Monacolin K Production.

Applications of beneficial secondary metabolites produced by () could be greatly limited for citrinin, a kidney toxin. The link of NaCl with cell growth and secondary metabolites in was analyzed with supplementations of different concentrations of NaCl in medium. The content of citrinin was reduced by 48.

Removal of hexanal in cooking fume by combination of storage and plasma-catalytic oxidation on alkali-modified Co-Mn solid solution.

Cooking oil fumes as an important source of volatile organic compounds in metropolitan areas are poisonous to the environment and human health. In this study, the removal of hexanal (a representative of cooking fume) using "storage-plasma catalytic oxidation" at ambient conditions has been investigated. Alkali-modified Co-Mn catalysts were synthesized by coprecipitation method and further characterized by XRD, SEM, N adsorption-desorption, H-TPR, O-TPD and XPS techniques.

iTRAQ-Based Quantitative Proteomic Analysis Reveals Changes in Metabolite Biosynthesis in in Response to a Low-Frequency Magnetic Field.

Background: Low-frequency magnetic fields (LF-MFs) dampen the citrinin output by in fermentations. The influence of LF-MFs on biosynthesis by was evaluated at the protein level.

Methods: Cultures were treated with a 1.

Effects of extremely low frequency magnetic field on production of mannatide by α-hemolytic Streptococcus.

The effect of the extremely low frequency magnetic field (ELF-MF) on biomass and mannatide production by α-hemolytic Streptococcus in liquid-state fermentation culture medium was studied during shake flask culture. Magnetic field (MF) inductions, exposure times, and exposure periods varied in a range of 0-1.5 mT, 0-16 h, and six periods of incubation time, respectively.

Thermal inactivation of Salmonella enteritidis PT 30 in almond kernels as influenced by water activity.

Salmonellosis outbreaks related to consumption of raw almonds have encouraged the scientific community to study the inactivation kinetics of pathogens in this dry commodity. However, the low moisture content of the product presents a challenge for thermal control, because the time required to achieve the desired thermal inactivation of microorganisms increases sharply with reduced moisture content and water activity. In this study, we explored and modeled the heat inactivation of Salmonella enterica serovar Enteritidis PT 30 in almond cultivar 'Nonpareil' kernel flour at four water activity (a(w)) values (0.