Publications by authors named "Mengxian Tian"
Article Synopsis
- Fluorosis poses a global health risk, affecting heart development in embryos, and this study specifically investigated the toxic effects of sodium fluoride (NaF) on zebrafish embryos.
- Key findings included a 50% lethal concentration of NaF at 335.75 mg/L, significant deformities in embryos at concentrations above 200 mg/L, and a dose-dependent reduction in heart rate and cardiac function.
- High-throughput RNA sequencing revealed 1354 differentially expressed genes linked to heart development in NaF-treated embryos, activating pathways related to cardiac function and malformation, thus uncovering the mechanisms behind fluoride-induced heart abnormalities.
Introduction: Fluoride is considered an environmental pollutant that seriously affects organisms and ecosystems, and its harmfulness is a perpetual public health concern. The toxic effects of fluoride include organelle damage, oxidative stress, cell cycle destruction, inflammatory factor secretion, apoptosis induction, and synaptic nerve transmission destruction. To reveal the mechanism of fluorosis-induced brain damage, we analyzed the molecular mechanism and learning and memory function of the SIRT1-mediated BDNF-TrkB signaling pathway cascade reaction in fluorosis-induced brain damage through experiments.
View Article and Find Full Text PDFBackground: 3D cancer stem cell (CSC) cultures are widely used as in vitro tumor models. In this study, we determined the effects of enriching HCT116 tumor spheres initially cultured in serum-free medium with different concentrations of serum, focusing on the effect of microserum environment stimulation on extraction and biological function of colorectal cancer stem cells (CCSCs).
Methods: CCSCs were enriched in standard serum-free medium and serum-free medium with different concentrations of serum for 1 week.