Pulsed radio frequency energy (PRFE) therapy is a non-invasive, electromagnetic field-based treatment modality successfully used in clinical applications. However, conventional PRFE devices are often bulky, expensive, and require extended treatment durations, limiting patient adherence and efficacy. Here, we present a lightweight, cost-effective wearable PRFE system consisting of a flexible electronic bandage and a smartphone.
View Article and Find Full Text PDFWireless and battery-free radio-frequency (RF) sensors can be used to create physical spaces that ambiently sense and respond to human activities. Making such sensors ultra-flexible and transparent is important to preserve the aesthetics of living environments, accommodate daily activities, and functionally integrate with objects. However, existing RF sensors are unable to simultaneously achieve high transparency, flexibility, and the electrical conductivity required for remote room-scale operation.
View Article and Find Full Text PDFPrevious evidence has confirmed that branched-chain aminotransferase-1 (BCAT1), a key enzyme governing branched-chain amino acid (BCAA) metabolism, has a role in cancer aggression partly by restricting αKG levels and inhibiting the activities of the αKG-dependent enzyme family. The oncogenic role of BCAT1, however, was not fully elucidated in acute myeloid leukemia (AML). In this study, we investigated the clinical significance and biological insight of BCAT1 in AML.
View Article and Find Full Text PDFBackground: Breast cancer, one of the most prevalent malignant tumors in females, usually occurs in the breast epithelial tissues.
Objective: The study aimed to explore the diagnostic value of contrast-enhanced ultrasound (CEUS) combined with shear wave elastography (SWE) in the diagnosis of benign and malignant breast masses in BI-RADS (Breast Imaging Reporting and Data System) 4.
Methods: Examination outcomes and clinical information of 83 patients with BI-RADS 4 breast masses were analyzed retrospectively.
Conductive yarns have emerged as a viable alternative to metallic wires in e-Textile devices, such as antennas, inductors, interconnects, and more, which are integral components of smart clothing applications. But the parasitic capacitance induced by their micro-structure has not been fully understood. This capacitance greatly affects device performance in high-frequency applications.
View Article and Find Full Text PDFIntroduction: Recent studies have suggested that CD300A was an oncogene in acute myeloid leukemia (AML) development. However, the clinical relevance and biological insight into CD300A expression in AML are still not well understood. The present study aimed to examine the expression characteristics of CD300A in AML and confirmed its clinical significance for AML.
View Article and Find Full Text PDFA three-component reaction of alkenyl-tethered oxime ethers, sodium metabisulfite, and aryldiazonium tetrafluoroborates under mild conditions is developed. This reaction proceeds at room temperature without any oxidants or additives, affording β-amino sulfones with good functional group tolerance through aminosulfonylation of unactivated alkene. Mechanistic studies show that this transformation undergoes a radical process, including radical trapping with sulfur dioxide and radical 1,4-amino migration.
View Article and Find Full Text PDFNeuroimaging studies have revealed a distributed neural network involving multiple fronto-temporal regions that are active during syntactic processing. Here, we investigated how these regions work collaboratively to support syntactic comprehension by examining the behavioral relevance of the global functional integration of the syntax network (SN). We found that individuals with a stronger resting-state within-network integration in the left posterior middle temporal gyrus (lpMTG) were better at syntactic comprehension.
View Article and Find Full Text PDFKeypads constructed from fabric materials are the ideal input devices for smart clothing applications. However, multi-modal reaction problems have to be addressed before they can be of practical use on apparels, i.e.
View Article and Find Full Text PDFOne of the most remarkable functional feats accomplished by visual system is the interpolation of missing retinal inputs based on surrounding information, a process known as perceptual completion. Perceptual completion enables the active construction of coherent, vivid percepts from spatially discontinuous visual information that is prevalent in real-life visual scenes. Despite mounting evidence linking sensory activity enhancement and perceptual completion, surprisingly little is known about whether and how attention, a fundamental modulator of sensory activities, affects perceptual completion.
View Article and Find Full Text PDFModulating PD-1 expression can constrain tumor growth. Hodgkin's lymphoma patients commonly express PD-L1 on tumor cells. We report the case of a 60-year-old male patient with relapsed classical Hodgkin's lymphoma who suffered from immediate-onset chill, hyperthermia and polyuria following initial treatment with sintilimab, an anti-PD-1 monoclonal antibody.
View Article and Find Full Text PDFWe report a method to sense a surrounding chiral drug based on D-type single-mode photonic crystal fiber (PCF) sensors in this paper. The electromagnetic theory of surface plasmon resonance on metal-chiral drug structure is derived. The wave equation containing constitutive relations of a chiral drug is given and integrated into the finite element method to compute the effective refractive index, confinement loss, and plasmon resonance wavelength for a D-type PCF sensor immersed in the chiral drug.
View Article and Find Full Text PDFIt has been proposed that visual learning is accomplished not only by neural plasticity in the visual cortex, but also by complex interactions between bottom-up and top-down processes that may induce global network reorganization. Here, we applied a multivariate analysis to functional connectivity (FC) patterns across the brain to investigate how visual association learning was achieved through large-scale network reorganization. Participants were trained to associate a set of artificial line-drawing objects with English letters.
View Article and Find Full Text PDFFront Hum Neurosci
January 2021
Gender roles are anti-dichotomous and malleable social constructs that should theoretically be constructed independently from biological sex. However, it is unclear whether and how the factor of sex is related to neural mechanisms involved in social constructions of gender roles. Thus, the present study aimed to investigate sex specificity in gender role constructions and the corresponding underlying neural mechanisms.
View Article and Find Full Text PDFFront Behav Neurosci
December 2020
Fear of punishment prompts individuals to conform. However, why some people are more inclined than others to conform despite being unaware of any obvious punishment remains unclear, which means the dispositional determinants of individual differences in conformity propensity are poorly understood. Here, we explored whether such individual differences might be explained by individuals' stable neural markers to potential punishment.
View Article and Find Full Text PDFFront Hum Neurosci
November 2020
Repeated practice is fundamental to the acquisition of skills, which is typically accompanied by increasing reliability of neural representations that manifested as more stable activation patterns for the trained stimuli. However, large-scale neural pattern induced by learning has been rarely studied. Here, we investigated whether global connectivity patterns became more reliable as a result of motor learning using a novel analysis of the multivariate pattern of functional connectivity (MVPC).
View Article and Find Full Text PDFMicroRNAs (miRNAs) and N-methyladenosine (mA) are known to serve as key regulators of acute myeloid leukemia (AML). Our previous microarray analysis indicated miR-550-1 was significantly downregulated in AML. The specific biological roles of miR-550-1 and its indirect interactions and regulation of mA in AML, however, remain poorly understood.
View Article and Find Full Text PDF: Apigenin, a flavonoid phytochemical extracted from fruits and vegetables, has shown anti-neoplastic effects in a variety of malignant tumors. DLBCL is the most common type of aggressive lymphoma in adults with a poor prognosis. Small-molecule inhibitors like BTK inhibitors have demonstrated extended period of disease control.
View Article and Find Full Text PDFEpidemiologic studies of the relationship between nitrite or nitrate consumption and risk of non-Hodgkin lymphoma (NHL) remain controversial. The current meta-analysis aimed to reexamine the evidence and quantitatively evaluate that relationship. Manuscripts were retrieved from the Web of Science, Chinese National Knowledge Infrastructure and PubMed databases up to May 2019.
View Article and Find Full Text PDFThe electromagnetic field theory for a step-index fiber geometry is developed to sense a surrounding chiral drug via long-period fiber gratings (LPFGs). This theory employs Debye potentials and electromagnetic fields for cladding modes in the LPFGs by introducing constitutive relations for a chiral drug. The fields in the chiral drug are transformed and decomposed into right- and left-hand circularly polarized components to account for the magnetoelectric coupling due to the chirality.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) is a devastating disease. Hybrid agents with dual activity, which have been shown to possess anti-cancer effect, are expected to potentially improve the prognosis of AML patients. EDO-S101 is a novel alkylating deacetylase inhibitor molecule synthesized by the addition of the hydroxamic acid of histone deacetylases inhibitor vorinostat into bendamustine, a DNA-damaging agent.
View Article and Find Full Text PDFIbrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AML cells, especially those harboring FLT3-ITD mutations. Abivertinib was also found to be more sensitive than ibrutinib in treating AML.
View Article and Find Full Text PDFHomoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia. Here we show that in acute myeloid leukemia (AML), homoharringtonine potently inhibits cell growth/viability and induces cell cycle arrest and apoptosis, significantly inhibits disease progression , and substantially prolongs survival of mice bearing murine or human AML. Strikingly, homoharringtonine treatment dramatically decreases global DNA 5-hydroxymethylcytosine abundance through targeting the SP1/TET1 axis, and depletion mimics homoharringtonine's therapeutic effects in AML.
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