Autophagy is essential for somatic embryogenesis in citrus through regulating amyloplast degradation and lipid homeostasis.

Autophagy is a conserved degradation pathway that regulates the clearance of paternal substrate at the early embryogenesis stage of animals. However, its mode of action is likely different in plants, which can regenerate through apomixis without fertilisation. Somatic embryogenesis (SE) is a unique plant process widely used for plant propagation and germplasm utilisation.

Self-assembled nanoparticles of costunolide and glycyrrhizic acid for enhanced ulcerative colitis treatment.

Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address the clinical requirements of people suffering from this ailment. Despite the acknowledged potential of nanomedicines in the field of anti-inflammatory treatment, their widespread use in clinical settings is impeded by their expensive nature and the uncertainty surrounding their safety profiles.

Discovery, preparation and characterization of lipid-lowering alkylphenol derivatives from Syzygium jambos fruit.

The chemical characteristics and hypolipidemic effects of alkylphenols in the fruit of Syzygium jambos were investigated in this study. Three cardanols (1-3; 1 as a new compound) and three alkylresorcinols (4-6) were isolated and identified from S. jambos fruit.

The discovery of germacradienol synthase: Construction of genetically-engineered strain, glycosylated modification, bioactive evaluation of germacradienol.

Germacradienol is a main precursor in the biosynthesis of geosmin-type terpenes by a variety of microbes, but its biological activities are still unknown. In the biosynthetic mechanism study of an antifungal degraded sesquiterpenoid (1β,4β,4aβ,8aα)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-diol (5) with a geosmin scaffold, the germacradienol synthase B7C62_00490 was identified. To exploit the synthetic potential of the enzyme to create germacradienol, engineered strains were constructed by introducing key synthases of farnesyl diphosphate, germacradienol synthase B7C62_00490 and glycosyltransferase UGT73C5 in Escherichia coli BL21(DE3).

Converting Poisonous Sulfate Species to an Active Promoter on TiO Predecorated MnO Catalysts for the NH-SCR Reaction.

MnO-based catalysts possess excellent low-temperature NH selective catalytic reduction (NH-SCR) activity, but the poor SO/sulfate poisoning resistance and the narrow active-temperature window limit their application for NO removal. Herein, TiO nanoparticles and sulfate were successively introduced into MnO-based catalysts to modulate the NH-SCR activity, and the active-temperature window (NO conversion above 80%, ) was significantly broadened to 100-350 °C (SO-TiO@MnO) compared to that of the pristine MnO catalyst (ca. : 100-268 °C).

Characterization of insoluble dietary fiber from three food sources and their potential hypoglycemic and hypolipidemic effects.

Dietary fiber is an important nutrient for improving human health and controlling calorie intake, and is used to produce functional foods. In this study, insoluble dietary fiber (IDF) from three sources (enoki mushrooms, carrots, and oats) was characterized and their hypoglycemic and hypolipidemic effects were determined with in vitro and in vivo models. The results of Scanning electron microscopy (SEM) showed that the IDF from the three sources have different morphologies.

Identification of molecular characteristics induced by radiotherapy in rectal cancer based on microarray data.

The present study aimed to reveal the molecular characteristics induced by radiotherapy in rectal cancer at the transcriptome level. Microarray data (ID, GSE26027) downloaded from the Gene Expression Omnibus database were re-analyzed to identify differentially expressed genes (DEGs) between rectal cancer tissues during and prior to radiotherapy. The DEGs were then inputted into the database for annotation, visualization and integrated discovery, an online tool to perform enrichment analyses, and into the search tool for the retrieval of interacting genes/proteins database to identify protein-protein interactions (PPIs).

More mind wandering, fewer original ideas: be not distracted during creative idea generation.

Several studies suggest that mind wandering (MW) benefits creativity when the MW occurs in the incubation period of creative problem solving. The aim of present study was to examine the effects of MW that occurs in the course of creative idea generation. Participants received an Alternative Uses Task (AUT) and were asked to generate ideas for 20min.