Research advances in the construction of stem cell-derived ovarian organoids.

Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and improving treatments, which benefits women's health. Constructing ovarian organoids involves two main processes: differentiating induced pluripotent stem cells (iPSCs) into germ and ovarian somatic cells to restore ovarian function and using extracellular matrix (ECM) to create a suitable ovarian microenvironment and scaffold. Although the technology is still in its early stages, future advancements will likely involve integrating high-throughput analysis, 3D-printed scaffolds, and efficient iPSC induction, driving progress in reproductive and regenerative medicine.

Based on sodium alginate coatings and dendritic copolymeric modification of curcumin delivery system: pH-sensitive nanospheres and strong tumor cytotoxicity.

This study aims to construct a novel drug delivery strategy to address the poor bioavailability and biostability of curcumin. A curcumin delivery strategy, basing on post-polymerization modification of poly(2-vinyl-4,4-dimethyl azlactone) to obtain conjugates of curcumin and dendritic polymers, combined with sodium alginate coating is reported. The curcumin-polymer conjugates were shown to have good fluorescence properties with fluorescence quantum yields of 0.

A Novel Ethylenediamine Bridged Indole-BODIPY Schiff Base Applied for Selective Response to Fe, Cu and Al Detection.

In this work, fluorescent compounds with Schiff base functional groups were obtained by using ethylenediamine bridged indole-BODIPY. The fluorescent probe Indole-ethylenediamine-BODIPY (ID-E-BP) and its performance in recognizing metal ions were investigated by UV and fluorescence spectroscopy, which showed that the fluorescent probe had a maximum absorption wavelength of 536 nm and a maximum emission wavelength of 557 nm. The fluorescent probe exhibited a fast and sensitive fluorescence quenching response effect in ethanol solution for Fe, Cu and Al, and the detection limits were 0.

Design, synthesis, and antitumor activity evaluation of BF-o, m, p-phenylenediamine bridged with pyrimidine-indole BF adduction derivatives.

Fluorescent drugs and pyrimidine-indole scaffolds have been shown to have advantages in cancer treatment. Fluorescent antitumor drugs BF-o, m, p-phenylenediamine pyrimidine-indole derivatives (PYB1, PYB2, and PYB3) were synthesized by linking pyrimidine and indole groups with aniline through a simple step and introducing BF. The drugs exhibit promising antitumor activity and their fluorescent properties make them useful for imaging purposes.

Mesenchymal Stem Cell Derived Exosomes Repair Uterine Injury by Targeting Transforming Growth Factor-β Signaling.

Intrauterine adhesions (IUA) refer to adhesions within the uterine cavity and cervix caused by injuries from uterine surgery. They are a significant cause of female infertility. Exosomes derived from mesenchymal stem cells (MSCs) play an active role in the treatment of IUA.