Efficiency Boost in Through Space Charge Transfer Emitters: Insights from Spiro Lateral Rocking Confinement.

Intramolecular through-space charge-transfer (TSCT) excited states have emerged as promising candidates for thermally activated delayed fluorescence (TADF) emitters. This study addresses the challenges in tuning excited state dynamics through conformational engineering, which significantly impacts exciton utilization. An effective strategy is presented to enhance the performance of TSCT-TADF molecules by restricting the lateral rocking of the spiro unit via immobilizing groups, which indirectly adjusts the conformations of the donor and acceptor subunits.

Stimulus-responsive magnetic enzyme-encapsulated coordination polymer for the potential field monitoring of alkaline phosphatase using personal glucometer.

Alkaline phosphatase (ALP) is an enzyme that can hydrolyze phosphate groups, and its activity is related to algal bloom outbreaks in eutrophic waters. A magnetic ALP-responsive material named FeO@INV/Zn-AMP was synthesized at room temperature by using zinc ions and adenosine monophosphate (AMP) as building blocks integrated invertase (INV). When ALP is present, it hydrolyzes the phosphate group of AMP, causing the disassembly of the FeO@INV/Zn-AMP material and the release of signaling molecule (INV).

Advanced Glycation End Products and Health: A Systematic Review.

Advanced glycation end products (AGEs) have garnered significant attention due to their association with chronic diseases and the aging process. The prevalence of geriatric diseases among young individuals has witnessed a notable surge in recent years, potentially attributed to the accelerated pace of modern life. The accumulation of AGEs is primarily attributed to their inherent difficulty in metabolism, which makes them promising biomarkers for chronic disease detection.

Uridine Diphosphate-Glycosyltransferase RpUGT344D38 Contributes to λ-Cyhalothrin Resistance in .

Uridine diphosphate-glycosyltransferase (UGT) is a key phase II enzyme in the insect detoxification system. Pyrethroids are commonly used to control the destructive wheat aphid . In this study, we found a highly expressed UGT gene, 34438, in both λ-cyhalothrin (LCR)- and bifenthrin (BTR)-resistant strains of .

RpUGT344J7 is involved in the reproduction switch of Rhopalosiphum padi with holocyclic life cycle.

Many aphid species exhibit both cyclical parthenogenesis (CP) and the obligate parthenogenesis (OP) life history, which are genetically determined. In CP aphid lineages, the parthenogenetic individuals can switch from asexual to sexual reproduction quickly in response to environmental factors such as changes in photoperiod and temperature. However, the OP aphid lineages do not undergo sexual reproduction under any conditions.

Reconstructing COVID-19 incidences from positive RT-PCR tests by deconvolution.

Background: The emergency of new COVID-19 variants over the past three years posed a serious challenge to the public health. Cities in China implemented mass daily RT-PCR tests by pooling strategies. However, a random delay exists between an infection and its first positive RT-PCR test.

UGT2B13 and UGT2C1 are involved in lambda-cyhalothrin resistance in Rhopalosiphum padi.

Uridine diphosphate-glucuronosyltransferases (UGTs) are major multifunctional detoxification phase II enzymes involved in the metabolic detoxification of xenobiotics. However, their roles in insecticides resistance are still unclear. In this study, we identified two UGTs genes (UGT2B13 and UGT2C1) in Rhopalosiphum padi, a serious insect pest of wheat worldwide.

MG53 alleviates airway inflammatory responses by regulating nuclear factor-κB pathway in asthmatic mice.

Background: Asthma is a common lung disease with increasing incidence and prevalence globally, thereby imposing a substantial global health and economic burden. Recently, studies have shown that Mitsugumin 53 (MG53) exhibits multiple biological functions and plays a protective role in a variety of diseases. However, the role of MG53 in asthma remained unknown; hence, in the present study we aimed to explore the functioning of MG53 in asthma.

RegCloser: a robust regression approach to closing genome gaps.

Background: Closing gaps in draft genomes leads to more complete and continuous genome assemblies. The ubiquitous genomic repeats are challenges to the existing gap-closing methods, based on either the k-mer representation by the de Bruijn graph or the overlap-layout-consensus paradigm. Besides, chimeric reads will cause erroneous k-mers in the former and false overlaps of reads in the latter.

Recyclable fluorescence sensing based on copper clusters for simultaneous determination of copper ions and ammonia.

A one-step strategy for synthesizing fluorescent copper clusters stabilized by L-cysteine has been successfully established in aqueous solutions. The direct determination of copper ions was realized by the fluorescence enhancement phenomenon caused by the preparation and aggregation process. At the same time, ammonia treatment can lead to rapid fluorescence quenching, resulting from the influence on the aggregation behavior of Cu clusters, while the fluorescence can be recovered by the continuous addition of copper ions.

Development and evaluation of machine learning models and nomogram for the prediction of severe acute pancreatitis.

Background And Aim: Severe acute pancreatitis (SAP) in patients progresses rapidly and can cause multiple organ failures associated with high mortality. We aimed to train a machine learning (ML) model and establish a nomogram that could identify SAP, early in the course of acute pancreatitis (AP).

Methods: In this retrospective study, 631 patients with AP were enrolled in the training cohort.

Physical simulation technologies and testing system for cavern shape control from single-well solution mining in rock salt.

The shape of the salt cavern is very important for the safe operation of gas storage facilities in rock salt. A physical simulation test is an effective means to study the shape control of salt caverns. To accurately simulate the process and parameters of single-well solution mining in rock salt, we developed simulation technologies and a testing system for cavern shape control.

RegScaf: a regression approach to scaffolding.

Motivation: Crucial to the correctness of a genome assembly is the accuracy of the underlying scaffolds that specify the orders and orientations of contigs together with the gap distances between contigs. The current methods construct scaffolds based on the alignments of 'linking' reads against contigs. We found that some 'optimal' alignments are mistaken due to factors such as the contig boundary effect, particularly in the presence of repeats.

Conducting and characterizing femto flow electrospray ionization.

Femto flow electrospray ionization (ESI) with flow rates ranging from 240 fL min to the low pico level (<10 pL min) was conducted and measured using a submicron emitter tip and relay ESI configuration. Signature analyte ion current intensities and profiles were observed. The obtained flow rate and ionization current enabled size calculation for initial charged nanodroplets.

A systematic review of Tuina for women with primary dysmenorrhea: A protocol for systematic review and meta-analysis.

Background: Primary dysmenorrhea (PD) occurs most often in adolescent girls. Tuina, a kind of Chinese massage, can effectively relieve women's pain and is widely used in clinical practice. However, there is no relevant systematic review show its effectiveness and safety.

Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review.

The rapid global spread of coronavirus disease 2019 (COVID-19) has promoted concern over human pathogens and their significant threats to public health security. The monitoring and control of human pathogens in public sanitation and health facilities are of great importance. Excessive sludge is an inevitable byproduct of sewage that contains human and animal feces in wastewater treatment plants (WWTPs).

Nested-channel for on-demand alternation between electrospray ionization regimes.

On-demand electrospray ionization from different liquid channels in the same emitter was realized using filamented capillary and gas phase charge supply. The solution sub-channel was formed when back-filling solution to the emitter tip by capillary action along the filament. Gas phase charge carriers were used to trigger electrospray ionization from the solution meniscus at the tip.

Efficacy of Baduanjin exercise for rehabilitation after COVID-19: A protocol for systematic review and meta-analysis.

Background: The study aims to evaluate the effectiveness and safety of Baduanjin exercise for rehabilitation after COVID-19.

Methods: The following electronic databases will be searched from establishment to Jan 2021: Cochrane Library, MEDLINE, EMBASE, Web of Science, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Wan-fang database, Chinese Scientific Journal Database, Chinese Biomedical Literature Databases, and other databases, All published randomized controlled trials about this topic will be included. Two independent researchers will operate article retrieval, duplication removing, screening, quality evaluation, and data analyses by Review Manager (V.

Interface-free integration of electrothermal vaporizer and point discharge microplasma for miniaturized optical emission spectrometer.

A tungsten coil (W-coil) as an electrothermal vaporizer (ETV) was interface-free integrated with a point discharge (PD) microplasma as an excitation source for a miniaturized optical emission spectrometer (OES). The PD microplasma and the W-coil ETV were vertically arranged in one quartz tube, and the W-coil was directly placed just under the PD without any physical interface. Working gas flow could sweep them successively to carry analytes released from the W-coil to the PD microplasma, and exhaust out of the quartz tube.

Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province.

Background: Measles outbreaks often require labor- and resource-intense response. A border-area measles outbreak occurred in Yunnan province that required outbreak response immunization for its containment. We report results of our investigation into the outbreak and the health sector costs of the response activities, with the goal of providing evidence for policy makers when considering the full value of vaccines and of measles elimination.

Low-grade fibromyxoid sarcoma: a clinicopathologic and molecular study of 10 genetically confirmed cases.

Low-grade fibromyxoid sarcoma (LGFMS) is a rare low-grade malignant fibroblastic tumor, harboring a characteristic or gene fusion. The authors presented 10 genetically confirmed cases in a Chinese population. To the best of our knowledge, the present series consists of the most genetically confirmed cases from a Chinese medical center in English literature.

ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK).

Protein lysine acetylation is one of the major posttranslational modifications (PTMs) with several thousands of proteins identified to be acetylated in mammalian tissues. Mechanistic studies have revealed important functions of acetylation in the regulation of protein function. Much less is known on how the acetyltransferases themselves are regulated.

Point Discharge Microplasma Optical Emission Spectrometer: Hollow Electrode for Efficient Volatile Hydride/Mercury Sample Introduction and 3D-Printing for Compact Instrumentation.

A miniaturized optical emission spectrometer was constructed with improved point discharge microplasma as an excitation source to enhance sample introduction efficiency and excitation efficiency. By using a hollow electrode as one of the discharge electrodes, analyte-containing chemical vapor yielded via hydride generation was transported and confined into the hollow electrode and subsequently guided into the microplasma with high sample introduction efficiency. Moreover, gaseous analyte species were directly diffused from inside the electrode into the center of the microplasma, instead of traditional external diffusion into the microplasma, resulting in sufficient participation in interactions and excitation in the plasma; thus, high excitation efficiency and stability can be achieved.