The formation of gastric precancerous-lesions (GPLs) has been identified as a critical step in tumorigenesis, and patients with GPLs have an increased risk of gastric cancer. Magnolol is the primary biphenolic compound in Magnolia officinalis. It possesses various pharmacological properties, such as cardioprotective and neuroprotective properties, and inhibit tumor growth.
View Article and Find Full Text PDFUnprecedented breakthroughs have been made in cancer immunotherapy in recent years. Particularly immune checkpoint inhibitors have fostered hope for patients with cancer. However, immunotherapy still exhibits certain limitations, such as a low response rate, limited efficacy in certain populations, and adverse events in certain tumors.
View Article and Find Full Text PDFThe coordination of chloroplast and nuclear genome status is critical for plant cell function. Here, we report that Arabidopsis CHLOROPLAST AND NUCLEUS DUAL-LOCALIZED PROTEIN 1 (CND1) maintains genome stability in the chloroplast and the nucleus. CND1 localizes to both compartments, and complete loss of CND1 results in embryo lethality.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2023
A twodimensional MXene (TaC) was innovatively used herein to modulate the space group and electronic properties of vanadium oxides, and the MXene/metal-organic framework (MOF) derivative VO(B)@TaC with 3D network crosslinking was prepared, which was then employed as a cathode to improve the performance of aqueous zinc ion batteries (ZIBs). A novel method combining HCl/LiF and hydrothermal treatments was used to etch TaAlC to obtain a large amount of accordion-like TaC, and the V-MOF was then hydrothermally grown on the surface of the stripped TaC MXene. During the annealing process of V-MOF@TaC, the addition of TaC MXene liberates the V-MOF from agglomerative stacking, allowing it to show additional active sites.
View Article and Find Full Text PDFThe desirable air cathode in Zn-air batteries (ZABs) that can effectively balance oxygen evolution and oxygen reduction reactions not only needs to adjust the electronic structure of the catalyst but also needs a unique physical structure to cope with the complex gas-liquid environment. In this work, first-principles calculations were carried out to prove that oxygen-terminated NbCO MXene played an active role in enhancing the sluggish reaction of oxygen intermediates. NbCO MXene could also stimulate the spatial accumulation of discharge products, which was beneficial to improve the stability of secondary ZABs.
View Article and Find Full Text PDFSustained anti-angiogenesis therapy increases the level of tumor hypoxia, leading to increased expression of HIF-1a, thereby contributing to the resistance to anti-angiogenesis therapy in hepatocellular carcinoma (HCC). Here, we report that phenazine biosynthesis-like domain-containing protein (PBLD) inhibits hypoxia-induced angiogenesis via ERK/HIF-1a/VEGF axis in HCC cells. Bioinformatic analysis of the TCGA database and clinical samples validation also identify a negative correlation between PBLD and angiogenesis-related genes expression including HIF-1a.
View Article and Find Full Text PDFHMGA1 protein is an architectural transcription factor that has been implicated in the progression of multiple malignant tumors. However, the role of HMGA1 in the growth and metastasis of gastric cancer (GC) has not yet been elucidated. Here, we show that HMGA1 is overexpressed in GC cells and the high expression of HMGA1 was correlated with worse survival in GC patients using a bioinformatics assay.
View Article and Find Full Text PDFBackground: Preoperative prediction of lymph node (LN) status is integral to determining the most appropriate treatment strategy for colorectal cancer (CRC). This study aimed to develop and validate a nomogram to predict LN metastasis in CRC preoperatively.
Methods: A total of 530 patients were enrolled and divided into training and validation cohorts.
Proc Natl Acad Sci U S A
June 2018
Photosystem II (PSII), a multisubunit protein complex of the photosynthetic electron transport chain, functions as a water-plastoquinone oxidoreductase, which is vital to the initiation of photosynthesis and electron transport. Although the structure, composition, and function of PSII are well understood, the mechanism of PSII biogenesis remains largely elusive. Here, we identified a nuclear-encoded pentatricopeptide repeat (PPR) protein LOW PHOTOSYNTHETIC EFFICIENCY 1 (LPE1; encoded by At3g46610) in , which plays a crucial role in PSII biogenesis.
View Article and Find Full Text PDFM-type thioredoxins are required to regulate zeaxanthin epoxidase activity and to maintain the steady-state level of the proton motive force, thereby influencing NPQ properties under low-light conditions in Arabidopsis. Non-photochemical quenching (NPQ) helps protect photosynthetic organisms from photooxidative damage via the non-radiative dissipation of energy as heat. Energy-dependent quenching (qE) is a major constituent of NPQ.
View Article and Find Full Text PDFAs a promising option out of all of the well-recognized candidates that have been developed to solve the coming energy crisis, polymer solar cells (PSCs) are a kind of competitive clean energy source. However, as a convenient and efficient method to improve the efficiency of PSCs, the inherent mechanism of the interfacial modification was still not so clear, and interfacial materials constructed with new units were limited to a large degree. Here we present a new kind of interfacial material consisting of AIE units for the first time, with an efficiency of 8.
View Article and Find Full Text PDFAs a reactive oxygen species (ROS), hypochlorite (OCl) plays a crucial role in oxidative stress and signal transduction, controlling a wide range of physiological functions. In addition, the wide use of OCl in the treatment of food and water might possibly threaten human health if the residual quantity was out of limits. Currently, sensitive methods employed to selectively monitor OCl in aqueous samples in situ are still scarce and badly needed.
View Article and Find Full Text PDFMaximizing light capture by light-harvesting pigment optimization represents an attractive but challenging strategy to improve photosynthetic efficiency. Here, we report that loss of a previously uncharacterized gene, HIGH PHOTOSYNTHETIC EFFICIENCY1 (HPE1), optimizes light-harvesting pigments, leading to improved photosynthetic efficiency and biomass production. Arabidopsis (Arabidopsis thaliana) hpe1 mutants show faster electron transport and increased contents of carbohydrates.
View Article and Find Full Text PDFIron (Fe) is an indispensable micronutrient for plant growth and development. The regulation of Fe homeostasis in plants is complex and involves a number of transcription factors. Here, we demonstrate that a basic helix-loop-helix (bHLH) transcription factor, bHLH104, belonging to the IVc subgroup of bHLH family, acts as a key component positively regulating Fe deficiency responses.
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