Identification of a Depolymerase Specific for K64-Serotype Potential Applications in Capsular Typing and Treatment.

Carbapenem-resistant (CRKP), one of the major nosocomial pathogens, is increasingly becoming a serious threat to global public health. There is an urgent need to develop effective therapeutic and preventive approaches to combat the pathogen. Here, we identified and characterized a novel capsule depolymerase (K64-ORF41) derived from phage SH-KP152410, which showed specific activities for K64-serotype.

Identification of a novel phage targeting methicillin-resistant Staphylococcus aureus In vitro and In vivo.

Introduction: Staphylococcus aureus is a common human pathogen that causes various diseases including infections on the skin, in the bloodstream and the lower respiratory tracts. The emergence of methicillin-resistant S. aureus (MRSA) made the treatment of the bacterial infection more difficult, calling for development of new therapeutics.

A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity Against Multidrug-Resistant Biofilm Degradation.

The increasing prevalence of infections caused by multidrug-resistant necessitates the development of alternative therapies. Here, we isolated, characterized, and sequenced a bacteriophage (SH-KP152226) that specifically infects and lyses capsular type K47. The phage SH-KP152226 contains a genome of 41,420 bp that encodes 48 predicted proteins.

Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-Resistant in Mice.

Carbapenem-resistant (CRAB) which is noted as a major pathogen associated with healthcare-associated infections has steadily developed beyond antibiotic control. Lytic bacteriophages with the characteristics of infecting and lysing specific bacteria have been used as a potential alternative to traditional antibiotics to solve multidrug-resistant bacterial infections. Here, we isolated -specific lytic phages and evaluated their potential therapeutic effect against lung infection caused by CRAB clinical strains.