Effects of internet-based mindfulness interventions on anxiety and depression symptoms in cancer patients: A meta-analysis.

Objective: This meta-analysis aimed to evaluate the effectiveness of internet-based mindfulness interventions on anxiety and depression symptoms in patients with cancer.

Methods: Eight databases (Cochrane Library, PubMed, Embase, and PsycINFO CNKI, Wanfang, VIP, and CBM) were systematically searched from the inception of databases to August 2023 for randomized controlled trials (RCTs). Two independent reviewers rigorously assessed the risk of bias and extracted data using a pre-established form.

Robust Integration of Fast Flavor Conversions in Classical Neutrino Transport.

The quantum kinetic evolution of neutrinos in dense environments, such as the core-collapse supernovae or the neutron star mergers, can result in fast flavor conversion (FFC), presenting a significant challenge to achieving robust astrophysical modeling of these systems. Recent works that directly simulate the quantum kinetic transport of neutrinos in localized domains have suggested that the asymptotic outcome of FFCs can be modeled by simple analytical prescriptions when coarse grained over a size much larger than the FFC length scale. In this Letter, by leveraging such a scale separation, we incorporate the analytical prescriptions into global simulations that solve the classical neutrino transport equation including collisions and advection under spherical symmetry.

Smart Design of Targeted Drug Delivery System for Precise Drug Delivery and Visual Treatment of Brain Gliomas.

In the treatment of glioma, which is one of the malignant tumors, although chemotherapy is used as the most common treatment method, it often suffers from low bioavailability. Therefore, improving the precision and efficiency of drugs is crucial in treating gliomas and a great challenge. Here, an advanced drug delivery system is reported for gliomas (CZQD@HA@DOX), which aggregates multiple features such as the susceptible imaging tracer property due to the use of CZQD and the targeting of HA to the receptor cluster 44 (CD44) of glioma cells, which provides the system with the functions of targeted enrichment and precise drug delivery at the tumor site.

"Bamboo-like" strong and tough sodium alginate/polyacrylate hydrogel fiber with directional controlled release for wound healing promotion.

Skin, as the biggest organ and outermost surface of the human body, is prone to injury due to various challenges, especially the expanding potential of accidents, which bring a huge social and economic burden. Hydrogels are emerging as the most promising candidate for wound dressings, which not only fulfill the varied requirements of dressings but also serve as drug carriers. But limited breathability, rapid drug release, and inadequate mechanical properties remains a significant challenge.

Metagenomic insights into the toxicity of carbamazepine to functional microorganisms in sludge anaerobic digestion.

Contaminants of emerging concern (CECs) contained in sludge, such as carbamazepine, may be toxic to microorganisms and affect the biogenesis of methane during anaerobic digestion. In this study, different scales of anaerobic digesters were constructed to investigate the inhibitory effect of carbamazepine. Results showed that carbamazepine reduced methane production by 11.

Deregulation of Ribosome Biogenesis in Nitrite-Oxidizing Bacteria Leads to Nitrite Accumulation.

Nitrite (NO) accumulation caused by nitrite-oxidizing bacteria (NOB) inhibition in nitrification is a double-edged sword, i.e., a disaster in aquatic environments but a hope for innovating nitrogen removal technology in wastewater treatment.

Comparative studies of immobilized polysaccharide derivatives chiral stationary phases for enantioseparation of furanocoumarins and dihydroflavones and discussion on chiral recognition mechanism.

Enantiomeric separation of furanocoumarins and dihydroflavones compounds were systematically studied in the normal-phase mode using four different polysaccharide-type chiral stationary phases, namely, Chiralpak IA, Chiralpak IC, Chiralpak IG, and Chiralpak IK-3 by high-performance liquid chromatography. The effect of alcohol modifiers and alcohol content on enantiomeric separation was evaluated for the separation of furanocoumarins and dihydroflavones. All the eight compounds have achieved baseline separation with the resolutions ranging between 1.

A practical method for rapid discrimination of constituents in Psoraleae Fructus by UPLC-Q-Orbitrap MS.

Psoraleae Fructus (PF) is one of the most frequently used traditional Chinese medicine, which has good efficacy in warming kidney to activate yang, promoting inspiration to relieve asthma and warming spleen to stop diarrhea. However, the chemical composition of PF is complex, which makes it difficult to determine its active and toxic components. In order to rapidly classify and identify the chemical components of the extracts from PF, this research was processed with CNKI, PubMed, and PubChem databases and data post-processing technique basing on ultrahigh performance liquid chromatography quadrupole orbitrap mass spectrometry (UPLC-Q-Orbitrap MS) technique.

Searching for Afterglow: Light Dark Matter Boosted by Supernova Neutrinos.

A novel analysis is performed, incorporating time-of-flight (TOF) information to study the interactions of dark matter (DM) with standard model particles. After supernova (SN) explosions, DM with mass m_{χ}≲O(MeV) in the halo can be boosted by SN neutrinos (SNν) to relativistic speed. The SNν boosted DM (BDM) arrives on Earth with TOF which depends only on m_{χ} and is independent of the cross section.

Comparison of two methods for extracting exosomes from the nucleus accumbens in mice.

Background: Exosomes bind to and are endocytosed by neurons of various brain regions. Methods for isolating and extracting exosomes from specific brain samples are critical. At present, the most important extractive methods for exosomes are Ultracentrifugation and exosome isolation kit extraction.

Identification and characterization of a novel hydroxylamine oxidase, DnfA, that catalyzes the oxidation of hydroxylamine to N.

Nitrogen (N) gas in the atmosphere is partially replenished by microbial denitrification of ammonia. Recent study has shown that Alcaligenes ammonioxydans oxidizes ammonia to dinitrogen via a process featuring the intermediate hydroxylamine, termed "Dirammox" (direct ammonia oxidation). However, the unique biochemistry of this process remains unknown.

Dirammox Is Widely Distributed and Dependently Evolved in and Is Important to Nitrogen Cycle.

Nitrogen cycle is an essential process for environmental health. Dirammox (ect onia idation), encoded by the cluster, was a novel pathway for microbial N production defined in HO-1. Here, a copy of the cluster as a whole was proved to have existed and very conserved in all genomes.

Novel Alcaligenes ammonioxydans sp. nov. from wastewater treatment sludge oxidizes ammonia to N with a previously unknown pathway.

Heterotrophic nitrifiers are able to oxidize and remove ammonia from nitrogen-rich wastewaters but the genetic elements of heterotrophic ammonia oxidation are poorly understood. Here, we isolated and identified a novel heterotrophic nitrifier, Alcaligenes ammonioxydans sp. nov.

Efficient and clean preparation of rare prosaikogenin D by enzymatic hydrolysis of saikosaponin B and response surface methodology optimization.

Prosaikogenin D, a rare secondary saponin in Radix Bupleuri, has much higher in vivo bioactivities than its original glycoside saikosaponin B. Its preparation methods, such as conventional acid hydrolysis and column chromatograph, are unfriendly to environment with serious pollution and undesired products. The aim of this study was to establish an efficient and clean approach for convenient preparation of this rare steroid saponin based on the enzymatic hydrolysis.

Enhanced adsorption of tetracycline by an iron and manganese oxides loaded biochar: Kinetics, mechanism and column adsorption.

A Fe/Mn oxides loaded biochar (FeMn-BC) was prepared to enhance the adsorption of tetracycline (TC). γ-FeO and MnO were assigned to the Fe and Mn oxides, respectively. The enhanced adsorption of TC was dominated by the loaded γ-FeO and MnO.

Construction of FeO@α-glucosidase magnetic nanoparticles for ligand fishing of α-glucosidase inhibitors from a natural tonic Epimedii Folium.

Inhibition of α-glucosidase activity is an effective way for treatment of type 2 diabetes mellitus. Epimedii Folium is an important source of α-glucosidase inhibitors (AGIs), however bioactive compounds and pharmacological mechanisms remained unclear. In this study, a novel strategy was established, which harnessed α-glucosidase functionalized magnetic beads to fish out potential AGIs, followed by UPLC-MS/MS analysis for their identification.

The dose regimen formulation of tilmicosin against Lawsonia intracellularis in pigs by pharmacokinetic-pharmacodynamic (PK-PD) model.

In this study, the rational dose regimens of tilmicosin against Lawsonia intracellularis (L. intracellularis) were studied using pharmacokinetic-pharmacodynamic (PK-PD) model approach to provide a maximal efficacy. The healthy and infected pigs were orally administrated the tilmicosin premix at a single dose of 10 mg/kg, and then the plasma and ileum content were collected at different time points.

Eco-efficient biphasic enzymatic hydrolysis for the green production of rare baohuoside I.

Baohuoside I, a rare secondary glycoside from Epimedii Folium, has anti-osteoporosis and other pharmacological effects. In addition, it exhibits improved bioactivities compared with its original glycoside icariin. Conventional methods for the production of baohuoside I, such as acid hydrolysis, exhibit very low efficiency with serious pollution and substantial byproducts.

Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents.

Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for veterinary antimicrobial agents are needed. Pharmacokinetics/Pharmacodynamics (PK/PD) models have been widely used to establish rational dosage regimens for veterinary antimicrobial agents that can achieve effective prevention and treatment of bacterial diseases and avoid the development of bacterial resistance.

Deregulation of phytoene-β-carotene synthase results in derepression of astaxanthin synthesis at high glucose concentration in Phaffia rhodozyma astaxanthin-overproducing strain MK19.

Background: A major obstacle to industrial-scale astaxanthin production by the yeast Phaffia rhodozyma is the strong inhibitory effect of high glucose concentration on astaxanthin synthesis. We investigated, for the first time, the mechanism of the regulatory effect of high glucose (> 100 g/L) at the metabolite and transcription levels.

Results: Total carotenoid, β-carotene, and astaxanthin contents were greatly reduced in wild-type JCM9042 at high (110 g/L) glucose; in particular, β-carotene content at 24-72 h was only 14-17% of that at low (40 g/L) glucose.

Determination of Tartrazine, Lutein, Capsanthin, Canthaxanthin and β-Carotene in Animal-Derived Foods and Feeds by HPLC Method.

Pigments are still widely used in food and feed industry and their resides in food might be harmful to human health due to their side effects. A high performance liquid chromatography (HPLC) method for simultaneous determination of pigments including tartrazine, lutein, capsanthin, canthaxanthin and β-carotene in animal-derived foods (including the muscle and liver of swine, the muscle, liver and skin of chicken and duck, and the muscle of fish) and feeds (swine, chicken and duck) was developed. Lutein, capsanthin, canthaxanthin and β-carotene were extracted with acetonitrile-ethyl acetate by ultrasonication, and tartrazine was extracted with water, followed by defatting with n-hexane and clean-up by solid phase extraction on weak anion exchange cartridges.

Fingerprints of Heavy-Element Nucleosynthesis in the Late-Time Lightcurves of Kilonovae.

The kilonova emission observed following the binary neutron star merger event GW170817 provided the first direct evidence for the synthesis of heavy nuclei through the rapid neutron capture process (r process). The late-time transition in the spectral energy distribution to near-infrared wavelengths was interpreted as indicating the production of lanthanide nuclei, with atomic mass number A≳140. However, compelling evidence for the presence of even heavier third-peak (A≈195) r-process elements (e.