A dual-switch electrochemical aptasensor for label-free detection of thrombin and ATP based on split aptamers.

Background: Aptamers, consisting of specialized single-stranded nucleic acids, are engineered through the SELEX technique to recognize specific targets with strong affinity. Aptamers are exceptionally useful in various sensor technologies, such as fluorescence-based sensors, electrochemical sensors, and colorimetric detection systems. Due to its high sensitivity, specificity and fast response, electrochemical aptasensor shows great application prospects in analytical detection, food safety, and environmental monitoring.

Transformation performance and subsystem coupling of resource-based cities in China: An analysis based on the support-pressure framework.

The sustainable development of resource-based cities is vital to China's high-quality development. Based on the support-pressure framework, this study simplifies the city system into an economy-society subsystem (ESS) and a resource-environment subsystem (RES), and measures the economy social developmental level (ESDL) and resource environmental carrying capacity (RECC) of China's 116 resource-based cities using the improved entropy-TOPSIS model. Then, it applies the coupling coordination degree (CCD) and relative development models to explore their coupling coordination relationships and relative developmental types.

Spatiotemporal regularity and spillover effects of carbon emission intensity in China's Bohai Economic Rim.

The Bohai Economic Rim (BER) is a momentous economic growth district with rapid development in northern China, but the environmental problems there have also become prominent. In 2017 the BER's carbon emission intensity outclassed the national average, the emission reduction situation was also grim. For clarifying the influence mechanism of the economy on carbon emission intensity, this paper explores the spatiotemporal regularity, the spatial correlation, and the spillover effect in carbon emission intensity employing the Moran index and the spatial Durbin model.