Adhesive Nanoparticle-in-Microgel System with ROS Scavenging Capability and Hemostatic Activity for Postoperative Adhesion Prevention.

Postoperative adhesion is a noteworthy clinical complication in abdominal surgery due to the existing physical barriers are unsatisfactory and inefficient in preventing its occurrence. In this work, an elaborate nanoparticle-in-microgel system (nMGel) is presented for postoperative adhesion prevention. nMGel is facilely formed by crosslinking manganese dioxide (MnO) nanoparticles-loaded gelatin microspheres with polydopamine using a modified emulsification-chemical crosslinking method, generating a nano-micron spherical hydrogel.

Biosafe Polydopamine-Decorated MnO Nanoparticles with Hemostasis and Antioxidative Properties for Postoperative Adhesion Prevention.

Surgical bleeding and cumulative oxidative stress are significant factors in the development of postoperative adhesions, which are always associated with adverse patient outcomes. However, effective strategies for adhesion prevention are currently lacking in clinical practice. In this study, we propose a solution using polydopamine-decorated manganese dioxide nanoparticles (MnO@PDA) with rapid hemostasis and remarkable antioxidant properties to prevent postsurgical adhesion.

Research progress on the roles of neurovascular unit in stroke-induced immunosuppression.

A complex pathophysiological mechanism is involved in brain injury following cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular structure consisting of neurons, endothelial cells, pericyte, astrocyte, microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly participates in the regulation of inflammatory immune process.

Preparation and surface modification of crab nanochitin for organogels based on thiol-ene click cross-linking.

Incompatibility of chitin nanomaterials with organic solvents is challenging in the design of the desirable organogels. The long hydrocarbon chains were covalently grafted on the surface of nanochitins, with the attachment of reactive allyl groups and improved dispersion in organic solvents. The reactive thiol groups of poly (ethylene glycol) were introduced into the allyl-nanochitin suspensions to produce the organogels by the thiol-ene click reaction.