Design terahertz polarizers and vector polarized vortex terahertz wave generators based on the effective dielectric constant of metal gratings.

Polarization and phase devices for terahertz waves have important applications in terahertz detection, imaging, communication, etc. Spatially variable metal gratings can be used for broad-spectrum, miniaturized, and low-cost terahertz polarization and phase modulation devices. Based on the effective dielectric constant and the theory of light propagation in multilayer media, we obtain the relationship between the transmittance and extinction ratio and the parameters such as the duty cycle of the metal grating, the frequency of the incident terahertz wave, the angle of incidence, the thickness of the metal grating, the refractive index of the substrate, and the thickness of the substrate.

High-Performance and Stable SbS Thin-Film Photodetectors for Potential Application in Visible Light Communication.

Photodetectors (PDs) are critical parts of visible light communication (VLC) systems for achieving efficient photoelectronic conversion and high-fidelity transmission of signals. Antimony sulfide (SbS) as a nontoxic, high optical absorption coefficient, and low-cost semiconductor becomes a promising candidate for applications in VLC systems. Particularly, SbS PDs were verified to have significantly weak light detection ability in the visible region.

Dehydration kinetics and mechanism of the stable isonicotinamide hydrate revealed by terahertz spectroscopy and DFT calculation.

The dehydration behavior of pharmaceutical hydrates has a great influence on its physiochemical properties such as stability, dissolution rate and bioavailability. However, how the intermolecular interactions vary during dehydration process remains elusive. In this work, we employed terahertz time-domain spectroscopy (THz-TDS) to probe the low-frequency vibrations and the dehydration process of isonicotinamide hydrate I (INA-H I).

Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L.

Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer initiation, progression and therapeutic resistance. Research shows that p53 mutants V157F and R158L occur with high frequency in lung squamous cell carcinomas.

Molecular dynamics study on the inhibition mechanisms of ReACp53 peptide for p53-R175H mutant aggregation.

p53 mutant aggregation can lead to loss-of-function (LoF), dominant-negative (DN) and gain-of-function (GoF) effects, involving in tumor growth. Finding inhibition methods of p53 mutant aggregation is a key step for developing new therapeutics against aggregation-associated cancers. Recent studies have shown that a cell-permeable peptide, ReACp53, can inhibit aggregation of the p53 mutant and restore p53 nuclear function as a transcriptional factor, showing extraordinary therapeutic potential.

Pseudo-topological property of Julia fractal vector optical fields.

Polarization singularities have topological properties, because they can maintain their features invariably during propagation. The topological property can be destroyed by shifting the polarization singularities away from the central axis, and this destruction originates from the space separation of spin angular momentum components. We find that paired centrosymmetric off-axis polarization singularities can recover the topological property in the Fourier plane (reciprocal space), which belongs to the pseudo-topological property.

Femtosecond polarization-structured optical field meets an anisotropic nonlinear medium.

Filamentation, as a universal femtosecond phenomenon that could occur in various nonlinear systems, has aroused extensive interest, owing to its underlying physics, complexity and applicability. It is always anticipated to realize the controllable and designable filamentation. For this aim, the crucial problem is how to actively break the symmetry of light-matter nonlinear interaction.

High-efficiency and flexible generation of vector vortex optical fields by a reflective phase-only spatial light modulator.

The scheme for generating vector optical fields should have not only high efficiency but also flexibility for satisfying the requirements of various applications. However, in general, high efficiency and flexibility are not compatible. Here we present and experimentally demonstrate a solution to directly, flexibly, and efficiently generate vector vortex optical fields (VVOFs) with a reflective phase-only liquid crystal spatial light modulator (LC-SLM) based on optical birefringence of liquid crystal molecules.

Fractal vector optical fields.

We introduce the concept of a fractal, which provides an alternative approach for flexibly engineering the optical fields and their focal fields. We propose, design, and create a new family of optical fields-fractal vector optical fields, which build a bridge between the fractal and vector optical fields. The fractal vector optical fields have polarization states exhibiting fractal geometry, and may also involve the phase and/or amplitude simultaneously.

Microstructures fabricated by dynamically controlled femtosecond patterned vector optical fields.

We have presented and demonstrated a method for the fabrication of various complicated microstructures based on dynamically controlled patterned vector optical fields (PVOFs). We design and generate dynamic PVOFs by loading patterned holograms displayed on the spatial light modulator and moving traces of focuses with different patterns. We experimentally fabricate the various microstructures in z-cut lithium niobate plates.

Hyperbolic-symmetry vector fields.

We present and construct a new kind of orthogonal coordinate system, hyperbolic coordinate system. We present and design a new kind of local linearly polarized vector fields, which is defined as the hyperbolic-symmetry vector fields because the points with the same polarization form a series of hyperbolae. We experimentally demonstrate the generation of such a kind of hyperbolic-symmetry vector optical fields.

Subwavelength multiple focal spots produced by tight focusing the patterned vector optical fields.

We numerically and experimentally explored generation and regulation of subwavelength multiple focal spots produced by tight focusing patterned vector optical fields (PVOFs). We presented a modified Richard-Wolf diffraction integration method suitable for the tight focusing of the PVOFs. By tailoring the spatial geometry and the polarization distributions of the PVOFs, simulations show that the diverse spatial configurations of subwavelength multiple focal spots can be achieved.