Publications by authors named "Mengqian Tu"
Purpose: Cytarabine (Ara-C) chemotherapy causes symptoms resembling meibomian gland dysfunction (MGD), suggesting potential associations between Ara-C and MGD. In this study, the pathological effects of Ara-C on MGD were investigated in a rodent model.
Methods: Mice received Ara-C with or without rosiglitazone (PPARγ agonist) for 7 consecutive days.
The accumulation of oleic acid (OA) in the meibum from patients with meibomian gland dysfunction (MGD) suggests that it may contribute to meibomian gland (MG) functional disorder, as it is a potent stimulator of acne-related lipogenesis and inflammation in sebaceous gland. Therefore, we investigate whether OA induces lipogenesis and inflammasome activation in organotypic cultured mouse MG and human meibomian gland epithelial cells (HMGECs). Organotypic cultured mouse MG and HMGECs were exposed to OA or combinations with specific AMPK agonists 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
View Article and Find Full Text PDFUrban Particulate Matter Triggers Meibomian Gland Dysfunction.
Invest Ophthalmol Vis Sci
February 2024
Purpose: The meibomian gland (MG), as the largest modified sebaceous gland, is potentially damaged by urban particulate matter (UPM) based on epidemiological evidence, but the specific experimental mechanisms remain unknown. This study investigated the effects of UPM on MG dysfunction (MGD) in rodent models.
Methods: Female C57BL/6J mice received eye drops containing UPM suspension or PBS for 14 days.
Obstruction of the Tear Drainage Altered Lacrimal Gland Structure and Function.
Invest Ophthalmol Vis Sci
July 2023
Article Synopsis
- - The study explores how the obstruction of tear drainage impacts the lacrimal glands (LG), which are crucial for tear production, aiming to uncover the connection between these two parts of the lacrimal system and their roles in ocular surface disorders.
- - Researchers created two mouse models with tear duct obstruction—one surgical and one genetic—and found that both groups displayed similar eye issues like excessive tearing and corneal damage, alongside significant changes in LG cell function and tear composition.
- - The findings indicate that when tear drainage is blocked, it disrupts LG function, highlighting the need to view the lacrimal apparatus as a unified system for better understanding and treatment of eye conditions.