Impacts of zinc caproate supplementation on growth performance, intestinal health, anti-inflammatory activity, and Zn homeostasis in weaned piglets challenged with Escherichia coli K88.

Background: Enterotoxigenic Escherichia coli (ETEC) is one of the primary causes of diarrhea in piglets, creating substantial economic losses in the swine farming industry worldwide. This study aimed to investigate the impacts of zinc caproate (ZnCA, CHOZn) on the intestinal health, growth performance, inflammatory status, and Zn homeostasis of weaned piglets challenged with ETEC K88. In total, 48 weaned piglets (Duroc × Landrace × Yorkshire, 7.

In situ ligand passivated organic-inorganic hybrid perovskite quantum dots for photocatalytic antibacterial applications.

The photoelectric properties of perovskite quantum dots make them have great potential in photocatalytic antibacterial applications. However, commonly used long-chain ligands are not conducive to the transfer of photogenerated charge carriers in perovskite quantum dots. In this work, we used short chain ligands with higher conjugated systems (BODIPY-OH) for surface regulated synthesis of MAPbBr quantum dots (BDP/QDs).

Mindfulness- and acceptance-based interventions for people with spinal cord injury: a scoping review.

Study Design: Scoping review.

Objective: To synthesize the effects of mindfulness- and acceptance-based interventions (MABIs) on health-related outcomes of individuals with spinal cord injury.

Setting: The included studies were conducted across four countries: The United States, Iran, China, and The United Kingdom.

Correction: Fabrication of nanoporous anodized aluminum oxide based photonic crystals with multi-band responses in the vis-NIR region.

Correction for 'Fabrication of nanoporous anodized aluminum oxide based photonic crystals with multi-band responses in the vis-NIR region' by Mengqi Li , , 2025, , 4099-4110, https://doi.org/10.1039/D4NR04744C.

Mogroside III improves bovine oocyte in vitro maturation by regulating autophagy in cumulus cells.

In vitro maturation (IVM) of oocytes is pivotal for successful embryo production. Cumulus cells (CCs) contribute to oocyte maturation through the secretion of hormones and nutrients, with proper autophagic activity being crucial for this process. However, the role of autophagy in CCs remains underexplored.

Effectiveness of Telehealth Interventions on Cognitive Function and Quality of Life in Adults With Neurological Disorders: A Systematic Review and Meta-Analysis.

Objective: Telehealth is an encouraging solution for the remote delivery of cognitive interventions. This review aimed to identify the characteristics and effectiveness of telehealth interventions on cognitive functions and related quality of life in adults with neurological disorders.

Design: Systematic review and meta-analysis.

Revealing the effects of lactate on bovine SCNT embryo development through transcriptome sequencing analyses.

As a major energy source in the metabolism of early embryos, lactate also participates in regulating zygotic gene expression and subsequently contributes to preimplantation embryonic development. Nevertheless, the influence of lactate on embryonic development in bovine cloned embryos remains elusive. For this reason, this research explored the differences in metabolic pathways between in vitro fertilization (IVF) embryos and somatic cell nuclear transfer (SCNT) embryos during zygotic genome activation (ZGA) using Smart-seq and observed changes in SCNT embryo development in response to lactate supplementation.

A Bibliometric Analysis of Healthcare Intervention-Related Studies Reporting Patient and Public Involvement and Engagement.

Background/objectives: Patient and public involvement and engagement (PPIE) has gained global recognition as an innovative healthcare research practice. PPIE engages end-users throughout the research process, improving intervention effectiveness, resource efficiency, and user satisfaction. Despite its increasing inclusion in studies, comprehensive bibliometric reviews of healthcare intervention-related studies reporting PPIE are scarce.

Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone.

Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, and biocompatibility. However, its inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts its clinical adoption. Herein, strontium (Sr) is incorporated onto the surface of PEEK using mussel-inspired polydopamine coating to improve its osteogenic activity.

Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis.

Background: Ischemic stroke is the second leading cause of death and the third leading cause of combined disability and mortality globally. While reperfusion therapies play a critical role in the management of acute ischemic stroke (AIS), their applicability is limited, leaving many patients with significant neurological deficits and poor prognoses. Neuroprotective agents have garnered attention for their potential as adjunct therapies; however, their relative efficacy remains unclear.

Microfluidic chip systems for color-based antimicrobial susceptibility test a review.

Clinical bacteria pose a significant public health threat, underscoring the need for reliable and rapid diagnostic methods for early disease detection, which can facilitate patient recovery. Current diagnostic methods for rapid pathogen detection often take hours to days and require numerous reagents and lengthy protocols. Microfluidic chip system offers a promising solution for clinical microbiology detection by reducing detection time with minimal setup and providing a point-of-care solution for patients.

A novel pyridine-2-one AMPK inhibitor: Discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model.

AMP-activated protein kinase (AMPK), a heterotrimeric serine-threonine kinase, has been identified as a promising target for regulating vascular remodeling in pulmonary arterial hypertension (PAH) due to its capacity to promote proliferation, autophagy, and anti-apoptosis in pulmonary artery smooth muscle cells (PASMCs). However, research into AMPK inhibitors is very limited. Herein, a virtual screening strategy was employed to identify CHEMBL3780091 as a lead compound for a series of novel AMPK inhibitors by exploring the structure-activity relationship around a specific pyridine-2-one scaffold.

Ultrasound-activated erythrocyte membrane-camouflaged Pt (II) layered double hydroxide enhances PD-1 inhibitor efficacy in triple-negative breast cancer through cGAS-STING pathway-mediated immunogenic cell death.

Immunogenic cell death (ICD) offers a promising avenue for the treatment of triple-negative breast cancer (TNBC). However, optimizing immune responses remains a formidable challenge. This study presents the design of RBCm@Pt-CoNi layered double hydroxide (RmPLH), an innovative sonosensitizer for sonodynamic therapy (SDT), aimed at enhancing the efficacy of programmed cell death protein 1 (PD-1) inhibitors by inducing robust ICD responses.

Fabrication of nanoporous anodized aluminum oxide based photonic crystals with multi-band responses in the vis-NIR region.

Photonic crystals (PC) play a key role in optical field modulation due to their unique photonic band gaps (PBGs). Anodic aluminum oxide (AAO) prepared by pulse anodization is a promising candidate for PC devices. In this research, an AAO-based PC with multi-band was fabricated on a single-slice & single-material film, which exhibits multi-band responses in the visible-to-near-infrared (vis-NIR) region.

Oxylipins as therapeutic indicators of herbal medicines in cardiovascular diseases: a review.

Globally, cardiovascular diseases (CVDs) remain the leading cause of death, and their prevention and treatment continue to face major challenges. Oxylipins, as novel circulating markers of cardiovascular disease, are crucial mediators linking cardiovascular risk factors such as inflammation and platelet activation, and they play an important role in unraveling cardiovascular pathogenesis and therapeutic mechanisms. Chinese herbal medicine plays an important role in the adjuvant treatment of cardiovascular diseases, which has predominantly focused on the key pathways of classic lipids, inflammation, and oxidative stress to elucidate the therapeutic mechanisms of cardiovascular diseases.

Coacervate-Derived Assembly of Poly(ethylene glycol) Nanoparticles for Combinational Tumor Therapy.

Coacervates have garnered significant attention as potential drug carriers. However, the instability resulting from their intrinsic membrane-free nature restricts the application of coacervates in drug delivery. Herein, the engineering of poly(ethylene glycol) nanoparticles (PEG NPs) is reported using coacervates composed of PEG and polyphenols as the templates, where PEG is subsequently cross-linked based on different chemistries (e.

The chain mediating role of rumination and psychological resilience in symptom burden and kinesiophobia in patients with chronic heart failure.

Objective: To explore the chain-mediating role and impact of rumination and psychological resilience on symptom burden and kinesiophobia in patients with chronic heart failure.

Methods: We selected a total of 318 patients with chronic heart failure from a hospital in Wuxi between November 2023 and May 2024 using a convenience sampling method. Various scales and questionnaires assessed general information, symptom burden, resilience, rumination thinking, and kinesiophobia.

[Correlation between inflammatory factors in gingival crevicular fluid and implant stability after oral implant restoration].

Purpose: To study the correlation between the levels of inflammatory factors in gingival crevicular fluid and implant stability and prognosis after oral implant restoration.

Methods: A total of 78 patients who underwent oral implant restoration surgery from August 2022 to August 2023 were selected as the experimental group. According to the results of X-ray examination 1 month after implantation, the patients were divided into poor prognosis subgroup(n=33) and good prognosis subgroup(n=45), another 60 healthy subjects who underwent physical examination during the same period were selected as the control group.

Chatbot-Based Mindfulness-Based Stress Reduction Program for University Students With Depressive Symptoms: Intervention Development and Pilot Evaluation.

Background: Depression is a growing concern among university students. Chatbots provide flexible, accessible, personalized psychosocial support. Delivering Mindfulness-Based Stress Reduction (MBSR) sessions via chatbots may reduce depressive symptoms in university students.

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.

Lithocholic acid (LCA) is accumulated in mammals during calorie restriction and it can activate AMP-activated protein kinase (AMPK) to slow down ageing. However, the molecular details of how LCA activates AMPK and induces these biological effects are unclear. Here we show that LCA enhances the activity of sirtuins to deacetylate and subsequently inhibit vacuolar H-ATPase (v-ATPase), which leads to AMPK activation through the lysosomal glucose-sensing pathway.

Lithocholic acid phenocopies anti-ageing effects of calorie restriction.

Calorie restriction (CR) is a dietary intervention used to promote health and longevity. CR causes various metabolic changes in both the production and the circulation of metabolites; however, it remains unclear which altered metabolites account for the physiological benefits of CR. Here we use metabolomics to analyse metabolites that exhibit changes in abundance during CR and perform subsequent functional validation.

Peer-supported interventions for people with spinal cord injury.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the effects of peer-supported interventions on quality of life and self-management compared with control (i.e.