Iron-Sulfur Clusters: A Key Factor of Regulated Cell Death in Cancer.

Iron-sulfur clusters are ancient cofactors that play crucial roles in myriad cellular functions. Recent studies have shown that iron-sulfur clusters are closely related to the mechanisms of multiple cell death modalities. In addition, numerous previous studies have demonstrated that iron-sulfur clusters play an important role in the development and treatment of cancer.

Childhood emotional neglect predicts empathic accuracy in social inclusion and exclusion contexts.

Previous studies have shown that individuals with a history of childhood emotional neglect show impaired empathy. However, accurately identifying emotions in others is an essential aspect of empathic functioning. The current study aimed to investigate the influence of childhood emotional neglect on empathic accuracy.

Up-regulation of LncRNA UCA1 by TGF-β promotes doxorubicin resistance in breast cancer cells.

Background: Doxorubicin (DOX) resistance remains a major challenge for adriamycin-based treatment of breast cancer (BC). Transforming growth factor β (TGF-β) has been reported to contribute to drug resistance. Although the role of long noncoding RNAs (LncRNAs) in cancer progression has been widely studied, its effect on TGF-β-induced resistance remains limited.

Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.

Cynaroside is the primary flavonoid component of honeysuckle which has been widely used as Chinese traditional medicine given its anti-inflammation properties. Overactive systemic inflammatory response and multi-organ injury are the leading causes of life-threatening sepsis. Regulation of macrophage polarization balance may act as a promising strategy for its treatment.

Collective self-esteem and perceived stress among the non-infected general public in China during the 2019 coronavirus pandemic: A multiple mediation model.

This study aimed to investigate the multiple mediating effects of perceived social support and anxiety between collective self-esteem and perceived stress during the 2019 coronavirus disease (COVID-19) pandemic. From February 18 to 25, 2020, 1921 participants aged 18-68 were recruited to complete the questionnaire online. The results showed that collective self-esteem reduced the perceived stress by increasing perceived social support and decreasing anxiety, and their chain mediation path.

Design of Hybrid Nanostructural Arrays to Manipulate SERS-Active Substrates by Nanosphere Lithography.

An easy-handling and low-cost method is utilized to controllably fabricate nanopattern arrays as the surface-enhanced Raman scattering (SERS) active substrates with high density of SERS-active areas (hot spots). A hybrid silver array of nanocaps and nanotriangles are prepared by combining magnetron sputtering and plasma etching. By adjusting the etching time of polystyrene (PS) colloid spheres array in silver nanobowls, the morphology of the arrays can be easily manipulated to control the formation and distribution of hot spots.