ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3.

Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor kinase subfamily, is activated in multiple cancer types through translocation or overexpression. Although several generations of ALK tyrosine kinase inhibitors (TKIs) have been developed for clinic use, drug resistance remains a major challenge. In this study, by quantitative proteomic approach, we identified the glycolytic regulatory enzyme, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), as a new target of ALK.

One-Pot Synthesis of Primary and Secondary Aliphatic Amines via Mild and Selective sp C-H Imination.

The direct replacement of sp C-H bonds with simple amine units (-NH ) remains synthetically challenging, although primary aliphatic amines are ubiquitous in medicinal chemistry and natural product synthesis. We report a mild and selective protocol for preparing primary and secondary aliphatic amines in a single pot, based on intermolecular sp C-H imination. The first C-H imination of diverse alkanes, this method shows useful site-selectivity within substrates bearing multiple sp C-H bonds.

A ring-shaped random laser in momentum space.

A ring-shaped random laser in momentum space is designed by directly coupling a random laser with a commercial optical fiber. By using a simple approach of selectively coating the random gain layer on the surface of the fiber, red and yellow random lasers are respectively achieved with low threshold values and a good emission direction due to the guiding role of optical fibers. The unique coupling mechanism leads to a random laser with a ring shape in momentum space, which is an excellent illuminating source for high-quality imaging with an extremely low speckle noise.

Solvent-Assisted Stepwise Redox Approach To Generate Zeolite NaA-Supported KO as Strong Base Catalyst for Michael Addition of Ethyl Acrylate with Ethanol.

Solid base catalysts featuring green, robustness, and high activity play an important role in the current fine-chemical and petrochemical industry. Normally, the generation of supported KO by thermal decomposition of KNO requires high temperature, and this process can sometimes destroy the structure of supporting materials. We herein report a solvent-assisted stepwise redox (SASR) approach to generate zeolite NaA-supported KO, which we call KO/NaA, that function as the solid base catalyst for Michael addition reaction between ethanol and ethyl acrylate.

Design, synthesis and antitumor activity of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives.

An asymmetric synthesis of a series of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives 3a-o is reported for the first time. Their structures were confirmed by 1H-NMR, 13C-NMR and MS. Their cytotoxic activity was evaluated by the MTT assay against three selected human cancer cell lines: HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), LS174T (human colon carcinoma).