The biomimetic nanoparticles (NPs) possessing abilities of tumor targeting and multimodal therapy show great potential for efficient combat of colon cancer. Herein, we developed a multifunctional biomimetic nanoplatform (FeO@PDA@CaCO-ICG@CM) based on CaCO-modified magnetic polydopamine (PDA) loaded with indocyanine green (ICG), which was encapsulated by a mouse lymphoma cell (EL4) membrane (CM) expressing functional proteins (i.e.
View Article and Find Full Text PDFNear-infrared (NIR) responsive nanoparticles are an important platform for multimodal phototherapy. Importantly, the simultaneous NIR-triggered photodynamic (PDT) and photothermal (PTT) therapy is a powerful approach to increase the antitumor efficiency of phototherapic nanoparticles due to the synergistic effect. Herein, a boron dipyrromethene (BODIPY)-based amphiphilic dye with enhanced electron donor-acceptor-donor (D-A-D) structure (BDP-AP) was designed and synthesized, which could self-assemble into stable nanoparticles (BDP-AP NPs) for the synergistic NIR-triggered PDT/PTT therapy.
View Article and Find Full Text PDFAggressive nature of colon cancer and current imprecise therapeutic scenarios simulate the development of precise and effective treatment strategies. To achieve this, a tumor environment-activated photosensitized biomimetic nanoplatform (PEG-SiNcTI-Ph/CpG-ZIF-8@CM) is fabricated by encapsulating metal-organic framework loaded with developed photosensitizer PEG-SiNcTI-Ph and immunoadjuvant CpG oligodeoxynucleotide within fusion cell membrane expressing programmed death protein 1 (PD-1) and cluster of differentiation 47 (CD47). By stumbling across, systematic evaluation, and deciphering with quantum chemical calculations, a unique attribute of tumor environment (low pH plus high concentrations of adenosine 5'-triphosphate (ATP))-activated photodynamic effect sensitized by long-wavelength photons is validated for PEG-SiNcTI-Ph/CpG-ZIF-8@CM, advancing the precision of cancer therapy.
View Article and Find Full Text PDFIn recent years, metal-organic frameworks (MOFs) have gained attention in the biomedical field, particularly as drug carriers for treating tumors. Therefore, we decided to synthesize a novel benzoic acid Zn-based MOF and study the Zn-based MOFs' drug-delivery properties and the drug-delivery system's anticancer effects. This study successfully synthesized a zinc-based MOF using solvent thermal synthesis.
View Article and Find Full Text PDFAs an essential micronutrient element in organisms, copper controls a host of fundamental cellular functions. Recently, copper-dependent cell growth and proliferation have been defined as "cuproplasia". Conversely, "cuproptosis" represents copper-dependent cell death, in a nonapoptotic manner.
View Article and Find Full Text PDFIn this study, the facile carbothermal reduction method was enforced using urea as dopant to modify the structure and chemical composition of nanoscale zero-valent-iron/biochar hybrid thereby boosting its reduction performance. Through fine-tuning the N-doped amount, the optimal nZVI/N-doped BC was obtained, which exhibited more active sites (nZVI, persistent free radicals (PFRs), pyrrolic-N) and superior electrochemical conductivity. With these blessings, the electrons originating from galvanic cell reaction could zip along the highway within the hybrid.
View Article and Find Full Text PDFA porous carbon obtained from cotton/polyester textile wastes was synthesized by the calcium acetate template method. This research studied the effect of preparation conditions and evaluated the characterization of porous carbon, and further explored its formation mechanism. The porous carbon possessed a high specific surface area of 1106.
View Article and Find Full Text PDFThe cotton textile was an abundant energy resource while was otherwise treated as waste. In this work, surfactants were used as catalysts in the hydrothermal carbonization (HTC) to transform cotton textile waste (CTW) into clean solid fuel. Furthermore, the conversion mechanisms of hydrothermal products during surfactant-assisted HTC were preliminarily proposed.
View Article and Find Full Text PDFConsidering the accumulation and high consumption of activating agents, anhydrous ethanol (AE) could be used to dissolve them to improve the dispersion effect, which was an effective way of improving the practical utilization rate. In this study, FeCl was dissolved in AE and further impregnated cotton textile waste (CTW) to prepare activated carbons (ACs) by pyrolysis. Afterward, ACs prepared in optimal conditions determined by the orthogonal experiment evaluated the physicochemical properties and adsorption capacities for Cr(VI).
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