Metal-free synthesis of 1,1-dimethyl-2,2,2-trifluoroethyl substituted quinazolinones tandem radical cyclization of quinazolin-4(3)-ones with 3,3,3-trifluoro-2,2-dimethylpropanoic acid.

A metal-free (NH)SO-mediated decarboxylative trifluoromethylation reaction of alkenes with 3,3,3-trifluoro-2,2-dimethylpropionic acid has been proposed. This method offers a novel route for the direct synthesis of a series of CMeCF-containing quinazolinones from basic chemical raw materials. The reaction mechanism was studied by a radical trapping test and DFT methods, verifying an oxidation-triggered cascade process promoted by the CMeCF radicals.

(NH)SO promoted tandem radical cyclization of quinazolin-4(3)-ones with oxamic acids for the construction of fused quinazolinones under metal-free conditions.

A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed. Under transition metal-free conditions, 36 quinazolinone derivatives containing an amide moiety were successfully synthesized, with the highest yield being 81%. This method involves the preparation of aminoacyl fused quinazolinone derivatives under mild conditions, offering advantages such as a high yield, a broad substrate compatibility, and a high atom economy.

Robust Mg(Ca)Zr-Doped Acid-Base Bifunctional Mesoporous Silica and Their Applications in the Deacetalization-Knoevenagel Reaction.

A series of Mg(Ca)Zr-doped acid-base bifunctional mesoporous silica were synthesized to study the impact of the one-step or two-step impregnation method on material structure. The two-step method seems to be a better way to synthesize metal-based functionalized catalyst and their catalytic performance is investigated using deacetalization-Knoevenagel reaction as the probe reaction. The coexisting dual active sites and suitable designing routes endowed highly efficient (Conv.

Mechanism of blood-brain barrier disruption by an Escherichia coli from lambs with severe diarrhea and meningoencephalitis.

Escherichia coli (E. coli) is a common conditional pathogen that is associated with a variety of infections in humans and animals. Although there are increasing reports regarding the infection of E.

Discovery of a virus of the species Enterovirus F in goats.

Here, we report two novel enteroviruses, designated as SD-S67 and SD-S68, isolated from a goat farm. Their complete genome sequences were determined and found to be 7455 and 7465 nucleotides in length, respectively. Molecular characterization revealed that SD-S67 is closely related to bovine enterovirus strain 261 and that SD-S68 to caprine enterovirus strain CEV-JL14.

Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response.

Background: The worsening problems of antibiotic resistance prompt the need for alternative strategies. Baicalin, which is isolated from Scutellaria baicalensisi, has been demonstrated to exhibit anti-inflammatory, anti-virulence and antimicrobial effects. Salmonella typhimurium is an important foodborne pathogenic bacteriaum that causes gastrointestinal disease in humans and many animals.