Publications by authors named "Mengling Zhao"
Article Synopsis
- - The study compared robotic-assisted laparoscopic vaginectomy (RALV) and conventional laparoscopic vaginectomy (CLV) for patients with vaginal high-grade squamous intraepithelial lesions (HSIL), finding RALV to have less blood loss, fewer complications, and shorter recovery times.
- - Both surgical methods showed similar high rates of HPV infection regression and vaginal HSIL regression after treatment, indicating effectiveness for managing the condition.
- - RALV was associated with significantly higher hospital costs compared to CLV, suggesting that while RALV may offer some operational advantages, it may not be the most cost-effective option.
Background: To summarise the application of minimally invasive surgery for female primary pelvic retroperitoneal tumours (PPRTs).
Methods: The clinical data of PPRT in a hospital between January 2017 and August 2022 were retrospectively collected. Surgical outcomes for cystic and solid tumours and two minimally invasive techniques were compared.
Article Synopsis
- * We identified 22 prognostic stemness-related genes (PSRGs) using methods like edgeR and WGCNA, which helped us develop a prediction model for metastatic ovarian cancer.
- * Key interactions in a network specific to ovarian cancer metastasis were revealed, including a notable connection between transcription factors NR4A1 and EGR3 and the TNFα signaling pathway, with Thioridazine identified as a potential inhibitor for stemness-related signatures.
Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines, especially Vernonia amygdalina, a famous nature medicine for the treatment of tonsillitis, diabetes, pneumonia. The current study was designed to combine molecular networking (MN) with diagnostic ions for rapid identification of Δ stigmastane-type saponins which were the α-glucosidase inhibitory active substances in V. amygdalina.
View Article and Find Full Text PDFVernoramyosides A-F (1-6), six new Δ stigmastane-type steroid saponins, along with four known analogues (7-10) were isolated from the leaves of Vernonia amygdalina Delile (Compositae). Their structures were determined by the combination of NMR, ECD and HR-ESI-MS data. These compounds all possessed highly oxidized side chain and a γ-lactam or α,β-unsaturated five-membered lactone ring.
View Article and Find Full Text PDFSix undescribed 1,8,9-phragmalin limonoid orthoesters (chukorthoesters A-F, 1-6) and two undescribed mexicanolide-type limonoids (ivorenoids H and I, 7 and 8), together with ten known limonoids, were isolated from the seeds of common wood-source and greening plants Chukrasia tabularis A. Juss. Their chemical structures were elucidated using HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and that of 1 along with absolute configuration was confirmed by X-ray diffraction experiment with Cu Kα radiation.
View Article and Find Full Text PDFIntroduction: Melia toosendan Sieb. et Zucc. has been used as a Chinese folk medicine for roundworm treatment since ancient times.
View Article and Find Full Text PDFThis article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.
View Article and Find Full Text PDFBackground: Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to investigate the association between metformin use and risk and prognosis of patients with EC.
Methods: PubMed, Embase, and the Cochrane Library databases were searched for observational studies evaluating the effect of metformin on EC prevention or treatment.