Publications by authors named "Menglin Wu"

Background: Kidney ultrasound (US) image segmentation is one of the key steps in computer-aided diagnosis and treatment planning of kidney diseases. Recently, deep learning (DL) technology has demonstrated promising prospects in automatic kidney US segmentation. However, due to the poor quality, particularly the weak boundaries in kidney US imaging, obtaining accurate annotations for DL-based segmentation methods remain a challenging and time-consuming task.

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Perceived control plays a crucial role in risk-taking behavior, but its neural effect on reward dynamics in risky and ambiguous decision making remains unclear. Here, we addressed this issue by measuring participants' (N = 40) EEG activity while they were performing a wheel-of-fortune task. Participants either made choices themselves (a high control condition) or followed the computer's choice (a low control condition) under risky or ambiguous decision contexts.

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Virus-derived small interfering RNAs (vsiRNAs) play an important role in viral infection by regulating the expression of host genes. At present, research on the regulation of plant primary metabolic pathways by vsiRNAs is very limited. TvsiRNA24 derived from tobacco curly shoot virus (TbCSV) was amplified by reverse transcription polymerase chain reaction, and its target gene NbTPI (triosephosphate isomerase) was verified using reverse transcription quantitative polymerase chain reaction and GFP fluorescence observation.

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Background: Targeted and systematic transperineal biopsy of lesions guided by magnetic resonance imaging (MRI) and transrectal ultrasonography (TRUS) fusion technique may optimize the biopsy procedure and enhance the detection of prostate cancer. We described the transperineal biopsy guided by an automatic MRI-TRUS fusion technique, and evaluated the accuracy and feasibility of this method in a prospective single-center study.

Methods: The proposed method focuses on automating the delineation of prostate contours in both the MRI and TRUS images, the registration and fusion of MRI and TRUS images, the generation and visualiztion of the systematic biopsy cores in their corresponding locations within the 2D and the 3D views, as well as the computation and visualiztion of needle trajectories from preoperative planning to intraoperative navigation.

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  • - The study investigates the detrimental effects of the plasticizer DEHP on chicken liver health, linking it to oxidative stress and the polarization of macrophages, which can exacerbate liver damage over time.
  • - Chronic exposure to DEHP leads to weight loss, liver damage, increased oxidative stress markers (like ROS and MDA), and changes in macrophage polarization, which is crucial in the inflammation process.
  • - Findings suggest that excessive M1 polarization, which promotes necroptosis, is a key mechanism behind DEHP-induced liver injury; the study indicates that the antioxidant N-acetylcysteine can inhibit this effect.
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  • MRI is a noninvasive imaging technique for soft tissue but faces challenges like low sensitivity and poor resolution.
  • Research has focused on magnetic nanoprobes, which enhance MRI contrast through their unique properties, including various structures based on elements like gadolinium, iron, and manganese.
  • The review highlights advancements in nanoprobes, their applications in monitoring major health issues, and future strategies for improving their performance, such as AI-driven designs and improved biocompatibility.
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  • The study investigated the role of the posterior parietal cortex (PPC) in visual working memory (VWM) feature binding using transcranial direct current stimulation (tDCS) across three experiments.
  • Results from Experiment 1 indicated that stimulating the PPC increased response times and non-target responses, suggesting a disruption in feature binding.
  • Follow-up experiments further clarified that while PPC stimulation affected response times, it didn't change recognition accuracy, highlighting the PPC's specific role in processing features during VWM retrieval.
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Regulatory T cells (Tregs) establish dominant immune tolerance but obstruct tumor immune surveillance, warranting context-specific mechanistic insights into the functions of tumor-infiltrating Tregs (TIL-Tregs). We show that enhanced posttranslational O-linked N-acetylglucosamine modification (O-GlcNAcylation) of cellular factors is a molecular feature that promotes a tumor-specific gene expression signature and distinguishes TIL-Tregs from their systemic counterparts. We found that altered glucose utilization through the glucose transporter Glut3 is a major facilitator of this process.

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Background: The monocyte-lymphocyte ratio (MLR) is a hematological test parameter that reflects the status of both monocytes and lymphocytes as inflammatory cells. This study aims to investigate the relationship between MLR and carotid intraplaque neovascularization (IPN) in patients with asymptomatic carotid stenosis.

Methods: We performed the Angio Planewave Ultrasensitive (AngioPLUS) screening for patients with carotid plaques.

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  • * Researchers measured reaction rates of chlorine with two compounds from seaweed, monoiodotyrosine (MIT) and diiodotyrosine (DIT), finding that temperature increases the rate of these reactions.
  • * The study identified multiple toxic byproducts formed during chlorination, with some having significant health risks, revealing the dangers of cooking with iodine-rich foods.
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Objective: Deep-learning algorithms have been widely applied in the field of automatic kidney ultrasound (US) image segmentation. However, obtaining a large number of accurate kidney labels clinically is very difficult and time-consuming. To solve this problem, we have proposed an efficient cross-modal transfer learning method to improve the performance of the segmentation network on a limited labeled kidney US dataset.

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Anhedonia is a transdiagnostic symptom and associated with a spectrum of reward deficits among which the motivational dysfunction is poorly understood. Previous studies have established the abnormal cost-benefit trade-off as a contributor to motivational deficits in anhedonia and its relevant psychiatric diseases. However, it remains elusive how the anhedonic neural dynamics underlying reward processing are modulated by effort expenditure.

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  • Giant Cell Arteritis (GCA) is an autoimmune disease that researchers are studying to understand how gut microbiota may influence its development and progression.
  • The study used advanced statistical methods to analyze the relationship between various gut microbial taxa and GCA, revealing significant associations with nine specific taxa.
  • Key findings indicated that certain gut microbiota can affect GCA risk through interactions with immune mediators, suggesting potential new approaches for treating the disease.
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Enzyme mimics (EMs) with intrinsic catalysis activity have attracted enormous interest in biomedicine. However, there is a lack of environmentally adaptive EMs for sensitive diagnosis and specific catalytic therapeutics in simultaneous manners. Herein, the coordination modulation strategy is designed to synthesize silicon-based phosphorescence enzyme-mimics (SiPEMs).

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The amount of cognitive and neural resources allocated to a task is largely determined by the reward we can expect. However, it remains under-appreciated how this reward-expectation-based control allocation is modulated by effort expenditure. The present event-related potential study investigated this issue through the lens of neural dynamics.

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Iodinated disinfection by-products (I-DBPs) exhibited potential health risk owing to the high toxicity. Our recent study demonstrated that I-DBPs from Laminaria japonica (Haidai), the commonly edible seaweed, upon simulated household cooking condition were several hundred times more than the concentration of drinking water. Here, the characterization of Haidai and its leachate tandem with the formation, identification and toxicity of I-DBPs from the cooking of Haidai were systemically investigated.

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Effort expenditure not only prospectively discounts the reward associated with it but also retrospectively adds the subjective value of reward, which is known as the effort paradox. This study aimed to resolve the effort paradox during reward evaluation through the critical lens of neural dynamics and its potential moderators. In total, 40 participants completed an effort-reward task wherein they exerted varying physical efforts to obtain an opportunity to win monetary rewards by active or passive decision-making.

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Image registration is a fundamental step for MRI-TRUS fusion targeted biopsy. Due to the inherent representational differences between these two image modalities, though, intensity-based similarity losses for registration tend to result in poor performance. To mitigate this, comparison of organ segmentations, functioning as a weak proxy measure of image similarity, has been proposed.

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  • DEHP (Di (2-ethyl) hexyl phthalate) is identified as an environmental endocrine disruptor that causes oxidative stress, threatening human and animal health.
  • In a study with male laying hens exposed to varying doses of DEHP, liver damage worsened with higher doses, indicated by increases in oxidative stress markers and changes in liver cell apoptosis-related proteins.
  • The findings suggest that DEHP induces liver cell apoptosis through oxidative stress by regulating the PTEN/PI3K/AKT pathway, and treatment with N-acetylcysteine (NAC) was able to mitigate these effects.
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We report the "water-in-oil-in-water" preparation of kidney injury molecule-1-targeting supramolecular chemiluminescence (CL) reporters (PCCS), consisting of L-serine-modified poly(lactic-co-glycolic) acid (PLGA)-encapsulated peroxyoxalate (CPPO), chlorin e6 (Ce6) and superoxide dismutase (SOD), for early diagnosis and amelioration of acute kidney injury (AKI). In this system, O ⋅ , a biomarker of AKI, triggers the oxidation of CPPO to 1,2-dioxetanedione and subsequent CL emission via CL resonance energy transfer to Ce6. The L-serine-modified PLGA stabilizes CPPO and Ce6 via noncovalent interactions, promoting long-lived CL (half-lives: ≈1000 s).

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A novel flame retardant phosphorus-containing organozinc complex (Zn-PDH) was prepared using zinc and iron as the metal center and 4-aminopyridine, with low steric hindrance, as the organic ligand, then using phosphazene to modify the organometallic complex (Zn-4APD). The flame retardant properties and mechanism of Zn-PDH/Tris-(3-DOPO-1-propyl)-triazinetrione (TAD) in epoxy resin (EP) were investigated. Flame inhibition behavior was studied by the vertical combustion test (UL94), while limiting oxygen index (LOI) measurement and flame retardant properties were studied by the cone calorimeter test (CONE).

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Cellulose has attracted considerable attention as a potential substitute for plastics. However, the flammability and high thermal insulation properties of cellulose contradict the unique requirements for highly integrated and miniaturized electronics i.e.

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IBS-D is a common functional bowel disease with complex etiology and without biomarker. The pathological and physiological basis of IBS-D focuses on visceral hypersensitivity. However, its epigenetic mechanism remains elusive.

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Objective: In this study, the efficacy and safety of salvianolate were compared with enoxaparin in the prevention of perioperative deep vein thrombosis in gastrointestinal surgery.

Methods: From October 2017 to September 2019, 563 patients who underwent gastrointestinal surgery were collected. Based on the inclusion and exclusion criteria, 119 patients were divided into two groups: enoxaparin group (n = 65) and salvianolate group (n = 54).

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Photocatalysis using the visible light of the sun is an environmentally friendly method of eliminating the NOx pollutant from the ambient air. Although CsBiBr, a semiconductor with a band gap of 2.54 eV, may be a strong absorber of visible light, its photocatalysis towards the abatement of NOx is unknown.

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