Two-stage robust telemedicine assignment problem with uncertain service duration and no-show behaviours.

The current pandemic of COVID-19 has caused significant strain on medical center resources, which are the main plac healthcare managers to make an effective assignment plan for the patients and telemedical doctors when providing telemedicine services. Motivated by this, we present the first comprehensive study of a two-stage robust telemedicine assignment problem when three different sources of uncertainty are incorporated, including uncertain service duration, no-show behaviours of both patients and telemedical doctors. From an algorithmic viewpoint, we propose an efficient nested column-and-constraint generation (C&CG) solution scheme that decomposes the model into an outer level problem and an inner level problem.

Inositol-Triphosphate 3-Kinase C and DNA Methylation Involvement in NLRP3 Inflammasome Activation in Kawasaki Disease.

Objective: To evaluate ITPKC and NLRP3 expression in children with Kawasaki disease (KD) and investigate the relationship between serum pro-inflammatory cytokines triggered by NLRP3 and inflammatory indices. Simultaneously, the methylation level in the ITPKC promoter was evaluated in children with KD.

Methods: Children who satisfied the American Heart Association diagnostic criteria for KD were enrolled in the study from August 2018 to January 2019.