Multiparameter-based bioassay of 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline, a newly-synthesized quinazoline derivative, toward Microcystis aeruginosa HAB5100 (cyanobacteria).

Quinazoline derivatives have wide biological activities and therapeutic properties, implying their potential for development and application on a large scale. In the present study, 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline (CMQ), was selected to examine its effect on unicellular cyanobacteria, Microcystis aeruginosa by evaluating growth, physiological and molecular responses. Growth was inhibited by CMQ, with a 96 h EC50 of 1.

Novel silver tetrafluoroborate catalyzed electrophilic cascade cyclization reaction: a facile approach to the synthesis of halo-substituted benzo[a]fluorenols.

A facile and novel silver tetrafluoroborate catalyzed electrophilic cascade cyclization reaction to generate halo-substituted benzo[a]fluorenols under mild conditions is disclosed. Good chemical selectivity and mild reaction conditions were involved in the transformation. The halide-containing benzo[a]fluorenols could be further elaborated via palladium-catalyzed cross-coupling reactions to introduce complexity.