Development and validation of a machine learning model to predict the risk of readmission within one year in HFpEF patients: Short title: Prediction of HFpEF readmission.

Background: Heart failure with preserved ejection fraction (HFpEF) is associated with elevated rates of readmission and mortality. Accurate prediction of readmission risk is essential for optimizing healthcare resources and enhancing patient outcomes.

Methods: We conducted a retrospective cohort study utilizing HFpEF patient data from two institutions: the First Affiliated Hospital Zhejiang University School of Medicine for model development and internal validation, and the Affiliated Hospital of Xuzhou Medical University for external validation.

Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery.

Background: Although numerous studies have shown that bariatric surgery results in sustained weight loss and modifications in gut microbiota composition and cognitive function, the exact underlying mechanisms are unclear. This study aimed to investigate the effects of bariatric surgery on cognitive function through the microbiota-gut-brain axis (MGBA).

Methods: Demographic data, serum samples, fecal samples, cognitive assessment scales, and resting-state functional connectivity magnetic resonance imaging (rs-fMRI) scans were obtained from 39 obese patients before and after (6 months) laparoscopic sleeve gastrectomy (LSG).

Core-Shell PEDOT-PVDF Nanofiber-Based Ammonia Gas Sensor with Robust Humidity Resistance.

Current ammonia sensors exhibit cross-sensitivity to water vapor, leading to false alarms. We developed a core-shell nanofiber (CSNF) structure to address these issues, using conductive poly(3,4-ethylenedioxythiophene) (PEDOT) as the core and hydrophobic polyvinylidene fluoride-tetrafluoroethylene (PVDF-TrFE) as the shell. The PEDOT-PVDF CSNF, with a diameter of ~500 nm and a 300 nm thick PVDF layer, showed a superior sensitivity and humidity resistance compared to conventional PEDOT membranes for ammonia concentrations of 10-100 ppm.

Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma.

Radiotherapy (RT) is commonly used to try to eliminate any remaining tumor cells following surgical resection of glioma. However, tumor recurrence is prevalent, highlighting the unmet medical need to develop therapeutic strategies to enhance the efficacy of RT in glioma. Focusing on the radiosensitizing potential of the currently approved drugs known to cross the blood-brain barrier can facilitate rapid clinical translation.

VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway.

von Hippel-Lindau (), known as a tumor suppressor gene, is frequently mutated in clear cell renal cell carcinoma (ccRCC). However, mutation is not sufficient to promote tumor formation. In most cases other than ccRCC, loss alters cellular homeostasis and causes cell stress and metabolic changes by stabilizing hypoxia-inducible factor (HIF) levels, resulting in a fitness disadvantage.

Associations between low muscle mass and clinical characteristics of health population in China.

Objectives: The primary aim of this study is to discern the association between specific clinical parameters and low muscle mass (LMM). We endeavor to elucidate the determinants of LMM and the predictive potency of individual factors.

Methods: In this retrospective cross-sectional study, we encompassed 450 older adult Chinese participants (252 males and 198 females).

Clinical significance of prostate cancer identified by transperineal standard template biopsy in men with nonsuspicious multiparametric magnetic resonance imaging.

Objective: Multiparametric magnetic resonance imaging (mpMRI) of the prostate has excellent sensitivity in detecting clinically significant prostate cancer (csCaP). However, whether a negative mpMRI in patients with a clinical suspicion of CaP can omit a confirmatory biopsy remains less understood and without consensus. Transperineal (TP) standard template biopsy (SBx) provides an effective approach to CaP detection.

VHL loss enables immune checkpoint blockade therapy by boosting type I interferon response.

Despite a moderate mutation burden, clear cell renal cell carcinoma (ccRCC) responds well to immune checkpoint blockade (ICB) therapy. Here we report that loss-of-function mutations in the von Hippel-Lindau (VHL) gene, the most frequent in ccRCC, underlies its responsiveness to ICB therapy. We demonstrate that genetic knockout of the gene enhanced the efficacy of anti-PD-1 therapy in multiple murine tumor models in a T cell-dependent manner.

Management of Lipedema Beyond Liposuction: A Case Study.

Lipedema is a pathologic accumulation of adipose tissue in the subcutaneous layer of the extremities. This connective tissue disorder, which predominately affects females, is often misdiagnosed despite an incidence of ∼11%. Misdiagnosis often leads to delays in appropriate treatment, further increasing the morbidity of the condition.

Defluorinative Multi-Functionalization of Fluoroaryl Sulfoxides Enabled by Fluorine-Assisted Temporary Dearomatization.

Owing to its unique physical properties, fluorine is often used to open up new reaction channels. In this report, we establish a cooperation of [5,5]-rearrangement and fluorine-assisted temporary dearomatization for arene multi-functionalization. Specifically, the [5,5]-rearrangement of fluoroaryl sulfoxides with β,γ-unsaturated nitriles generates an intriguing dearomatized sulfonium species which is short-lived but exhibits unusually high electrophilicity and thus can be instantly trapped by nucleophiles and dienes at a remarkably low temperature (-95 °C) to produce four types of valuable multi-functionalized benzenes, respectively, involving appealing processes of defluorination, desulfurization, and sulfur shift.

A continuation method for image registration based on dynamic adaptive kernel.

Image registration is a fundamental problem in computer vision and robotics. Recently, learning-based image registration methods have made great progress. However, these methods are sensitive to abnormal transformation and have insufficient robustness, which leads to more mismatched points in the actual environment.

Respiratory Syncytial Virus Matrix Protein Is Sufficient and Necessary to Remodel Host Mitochondria in Infection.

Although respiratory syncytial virus (RSV) is the most common cause of respiratory infection in infants, immunosuppressed adults and the elderly worldwide, there is no licensed RSV vaccine or widely applicable antiviral therapeutics We previously reported a staged redistribution of mitochondria with compromised respiratory activities and increased reactive oxygen species (ROS) generation during RSV infection. Here, we show for the first time that the RSV matrix protein (M) is sufficient and necessary to induce these effects. Ectopically expressed M, but not other RSV proteins, was able to induce mitochondrial perinuclear clustering, inhibition of mitochondrial respiration, loss of mitochondrial membrane potential (Δψ), and enhanced generation of mitochondrial ROS (mtROS) in infection.

sp. ., a New Petroleum-Degrading Bacteria Isolated from Oily Soils.

The microbial remediation technology had great potential and attracted attention to total petroleum hydrocarbon pollution (TPH) remediation, but its efficiency is limited by its application in the field. In this study, a new TPH-degrading strain, TDYN1, was isolated from contaminated oil soil in Dagang Oilfield in Tianjin, China, and identified as sp. by 16S rRNA sequence analysis.

Classification and Interpretability of Mild Cognitive Impairment Based on Resting-State Functional Magnetic Resonance and Ensemble Learning.

The combination and integration of multimodal imaging and clinical markers have introduced numerous classifiers to improve diagnostic accuracy in detecting and predicting AD; however, many studies cannot ensure the homogeneity of data sets and consistency of results. In our study, the XGBoost algorithm was used to classify mild cognitive impairment (MCI) and normal control (NC) populations through five rs-fMRI analysis datasets. Shapley Additive exPlanations (SHAP) is used to analyze the interpretability of the model.

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.

Unlabelled: The type I interferon response plays a pivotal role in promoting antitumor immune activity in response to radiotherapy. The identification of approaches to boost the radiation-induced type I interferon response could help improve the efficacy of radiotherapy. Here we show that the histone methyltransferase SETDB1 is a potent suppressor of radiation-induced endogenous retrovirus expression.

Evaluation of Different Pain-Control Procedures for Post-cardiac Surgery: A Systematic Review and Network Meta-Analysis.

Objective: To identify superior pain-control procedures for postoperative patients who undergo cardiac surgeries.

Methods: Literature searches were conducted in globally recognized databases, including MEDLINE, EMBASE and Cochrane Central, to identify randomized controlled trials (RCTs) investigating pain-control procedures after cardiac surgeries. The parameters evaluating analgesic efficacy and postoperative recovery, namely, the pain score and ICU stay, were quantitatively pooled and estimated using Bayesian methods.

Design and analysis of a performance monitoring system for a seed metering device based on pulse width recognition.

To realize real-time and accurate performance monitoring of large- and medium-sized seed metering devices, a performance monitoring system was designed for seed metering devices based on LED visible photoelectric sensing technology and a pulse width recognition algorithm. Through an analysis of the of sensing component pointing characteristics and seed motion characteristics, the layout of the sensing components and critical photoelectric sensing system components was optimized. Single-grain seed metering devices were employed as monitoring objects, and the pulse width thresholds for Ekangmian-10 cotton seeds and Zhengdan-958 corn seeds were determined through pulse width threshold calibration experiments employed at different seed metering plate rotational speeds.

Respiratory Syncytial Virus Matrix Protein-Chromatin Association Is Key to Transcriptional Inhibition in Infected Cells.

The morbidity and mortality caused by the globally prevalent human respiratory pathogen respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously demonstrated that the RSV matrix (M) protein shuttles, in signal-dependent fashion, between host cell nucleus and cytoplasm, and that this trafficking is central to RSV replication and assembly. Here we analyze in detail the nuclear role of M for the first time using a range of novel approaches, including quantitative analysis of de novo cell transcription in situ in the presence or absence of RSV infection or M ectopic expression, as well as in situ DNA binding.

Mediastinal Small Cell Carcinoma with Primary Cutaneous Cryptococcosis: A Rare Case Report.

Cutaneous cryptococcosis, an infectious disease resulting from , primarily affects immunodeficient individuals. Here, we report a case of mediastinal small cell carcinoma (MSCC) complicated with multiple skin and soft tissue infections mimicking erysipelas and cellulitis. Antibiotics for bacteria were ineffective and a culture of pus from the infected areas revealed in this patient.