Electrochemical sensor for effective detection of methyl parathion applying multidimensional MXene/CNHs/PPy nanocomposite to synergistically immobilize acetylcholinesterase.

In this study, a novel acetylcholinesterase (AChE)-based electrochemical sensor was successfully constructed using two-dimensional MXene, carbon nanohorns (CNHs) and polypyrrole (PPy) as the substrate material for the detection of methyl parathion (MP) residue. The multidimensional MXene/CNHs composite, formed through electrostatic self-assembly, provided a high specific surface area and excellent conductivity. With an active surface area of 0.

Microfluidic paper-based analysis device applying black phosphorus nanosheets@MWCNTs-COOH: A portable and efficient strategy for detection of β-Lactoglobulin in dairy products.

This study prepared a novel, portable and cost-effective microfluidic paper-based electrochemical analysis device (μ-PAD) using black phosphorus nanosheets@carboxylated multi-walled carbon nanotubes (BPNSs@MWCNTs-COOH) nanocomposites for β-lactoglobulin (β-LG) detection. At the appreciate ratio, the synthesized BPNSs@MWCNTs-COOH was demonstrated to not only serve as a high-quality substrate for the specific aptamer immobilization, but also improve the electron transfer capability of the sensing interface. The μ-PADs, utilizing BPNSs@MWCNTs-COOH and aptamer recognition, exhibited a wider detection range (10-1000 ng mL) and lower detection limit (LOD: 0.

Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease.

Alzheimer's disease (AD), one of the greatest threats to human health, is characterized by declined cognition and changed behavior. Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) that play an important role in learning and memory are hydrolyzed by phosphodiesterases (PDEs). Most PDE isoforms are highly expressed in the brain, and the inhibition of PDEs is beneficial to counteract AD.