Management of Spinal Deformities Caused by Osteoporotic Vertebral Fractures.

Osteoporosis and fragility play a significant role in the treatment and planning of patients with deformity secondary to osteoporotic vertebral fracture (OVF). The resulting deformity can present significant challenges for its management, both from a medical and surgical perspective. The need for a specific classification for these deformities, including the potential for the development of artificial intelligence and machine learning in predictive analysis, is emerging as a key point in the coming years.

Osteoporotic vertebral fractures localized in the lumbar area significantly impact sagittal alignment.

Unlabelled: Lumbar fractures and/or multiple fractures at the lumbar or thoracolumbar regions are risk factors for sagittal malalignment in patients older than 70 years old. Although patients with OVF show a huge capacity to compensate after the fractures, lumbar and TL lumbar fractures require closer monitoring.

Purpose: To assess the impact of osteoporotic vertebral fractures on the sagittal alignment of the elderly and identify risk factors for sagittal malalignment.

Anatomic trajectory for iliac screw placement adapts better to the morphological features of the pelvis of each individual than the S2 alar iliac screw: a radiological study.

Purpose: The iliac fixation (IF) through the S2 ala permits the minimization of implant prominence and tissue dissection. An alternative to this technique is the anatomic iliac screw fixation (AI), which considers the perpendicular axis to the narrowest width of the ileum and the width of the screw. The morphological accuracy of the iliac screw insertion of two low profile iliac fixation (IF) techniques is investigated in this study.

Simplified Pedicle Subtraction Osteotomy for Osteoporotic Vertebral Fractures.

Background: In osteoporotic vertebral fractures (OVF) involving neurological symptoms and severe kyphosis, vertebral osteotomies are necessary but are associated with a high risk of complications.

Methods: We performed a retrospective study. In 14 patients (mean age, 69.

Lung injury in patients age 75 years and older with the use of polymethylmethacrylate fenestrated pedicle screws.

Background Context: Pulmonary complications in patients age 75 years and older who undergo spinal fusion may have catastrophic consequences. The use of augmentation techniques with polymethylmethacrylate (PMMA) have been associated with pulmonary damage. The use of fenestrated pedicle screws augmented with PMMA may increase the risk of lung injury in this population.

Safety and Efficacy With Augmented Second-Generation Perforated Pedicle Screws in Treating Degenerative Spine Disease in Elderly Population.

Background: Degenerative spine disease is a common cause of low back pain in people age 65 years or older. Nonsurgical treatment is tried first, but if it is unsuccessful, surgery is advocated. This has special connotations for both underlying disease and the biomechanical characteristics of osteoporotic bone.

Assessment of differences in patient populations selected for excluded from participation in clinical phase III acute myelogenous leukemia trials.

Purpose: To compare patients treated in or outside clinical protocols, using de novo acute myeloid leukemia (AML) as a model disorder.

Patients And Methods: We retrospectively compared the characteristics of all patients with de novo AML diagnosed in the referral area of our university hospital between 1985 and 1994.

Results: Of a total of 170 AML patients, 45% were included in a phase III trial for the treatment of AML and 55% were treated outside a protocol.

Venous thrombosis and multiple prothrombotic gene defects. Case 5.

We describe the case of a 30-year-old woman with homozygous prothrombin G20210A transition and heterozygous FV Leiden mutation and a history of postpartum venous thrombosis. Despite the high thrombotic risk to be assumed in the presence of this combined thrombophilia our patient suffered her first venous thrombotic event only at the age of 29 years during the puerperium of her first pregnancy. This fact supports the concept of venous thrombosis as a multicausal disease, with interaction of genetic and acquired risk factors.

Severe IgA-mediated auto-immune haemolytic anaemia in a 48-yr-old woman.

Auto-immune haemolytic anaemia (AIHA) is characterised by haemolysis associated with the presence of the immunoglobulins IgG, IgM or IgA, and/or components of the complement system on the red cell membrane. The immunoglobulins react as auto-antibodies against the red cell antigens of the patient. IgG antibodies and the complement component C3d can be detected by the direct antiglobulin test (DAT); however, IgM and particularly IgA antibodies may not necessarily be detected by the broad-spectrum anti-human-globulin serum.