[Clinical analysis of cochlear implants related inflammatory reaction].

Objective: This article discusses the clinical features and treatment methods of the inflammatory reaction associated with cochlear implants, and analyzes the possible pathogenesis and related factors.

Method: We retrospectively analyzed postoperative inflammation cases from February 2002 to October 2013 among 825 cochlear implantation patients. Their symptoms, signs and treatment processes and outcomes were described and summarized.

[The impact of malleus processing in ossicular chain reconstruction on the therapeutic effect in patients with tympanosclerosis].

Objective: To investigate the effect of different malleus treatments on the postoperative efficacy in the tympanosclerosis patients receiving ossicular chain reconstruction.

Method: Fifty-nine patients (62 ears) with tympanosclerosis were treated by ossicular chain reconstruction. All the patients were divided into three groups, including malleus removal group (A, 24 ears), retaining only the malleus handle group (B, 18 ears) and the intact malleus group (C, 20 ears).

[Normal anatomy of aditus of antrum and antrum on high-resolution CT and three-dimensional reconstruction].

Objective: To study the normal anatomy of aditus of antrum and antrum on the high-resolution CT (HRCT) and the three-dimensional reconstruction, testing the normal range. And comparison was carried out according to the age, sex and side.

Method: Ninety cases were randomly selected without ear lesions.

[Applied anatomy of facial recess and posterior tympanum related to cochlear implantation].

Objective: To investigate the related parameters of temporal bone structure in the surgery of cochlear implantation through facial recess approach so as to offer a theoretical reference for the avoidance of facial nerve injury and the accurate localization.

Method: In a surgical simulation experiment, twenty human temporal bones were studied. The correlation parameters were measured under surgical microscope.

[Applied anatomy of scala tympani inlet related to cochlear implantation].

Objective: To investigate the related parameters of the temporal bone structure for determining the position of implanting electrode into the scala tympani in cochlear implantation surgery through the facial recess and epitympanum approach.

Methods: In a surgical simulation experiment, 20 human temporal bones were studied and measured to determine the related parameters of the temporal bone structure.

Results: The distance 5.

[The expressions of alpha-enolase in the nasopharyngeal cancer tissue].

Objective: To study the meaning of expressions of ENO1 in the nasopharyngeal cancer tissue.

Method: By using SP immunohistochemical methods.

Result: The positive expressions for ENO1 were 60.

[Cochlear implantation and rehabilitation in prelingually deafened adolescents and young adults].

Objective: To investigate the outcomes of prelingually deafened adolescents and young adults receiving cochlear implantation (CI).

Methods: Thirty-three patients with prelingual deafness aged 7-33 years at the time of CI were followed up for 4 years. The Speech Discrimination Score (SDS) was tested using disyllabic words and short sentences with close-set and open-set, respectively.

[Therapeutic effect of ossicular reconstruction with bioceramic or porous macromolecular polyethylene partial ossicular replacement prosthesis in patients with tympanosclerosis].

Objective: To evaluate the effect of ossicular reconstruction with partial ossicular replacement prosthesis (PORP) in patients with tympanosclerosis.

Methods: The data of 31 cases of tympanosclerosis treated between 1992 and 2009 were reviewed. Of the 31 patients, 17 (17 ears) underwent ossicular reconstruction with porous macromolecular polyethylene PORP, and 14 (14 ears) with bioceramic PORP.

[Study of three-dimensional speech chart by time-frequency analysis in Chinese Mandarin Monosyllabic word phonemes].

Objective: To investigate the physical characteristic of Chinese Mandarin Monosyllabic word phonemes by the time-frequency analysis.

Methods: Manufactured and study the three-dimensional speech chart which was on the basic of information of the time-frequency analysis in 40 monosyllabic words with the SigmaPlot 9.0 and Matlab 7.

[Cochlear implantation in patients with Waardenburg syndrome type II].

Objective: To describe the multi-channel cochlear implantation in patients with Waardenburg syndrome including surgeries, pre and postoperative hearing assessments as well as outcomes of speech recognition.

Method: Multi-channel cochlear implantation surgeries have been performed in 12 cases with Waardenburg syndrome type II in our department from 2000 to 2008. All the patients received multi-channel cochlear implantation through transmastoid facial recess approach.

[Tumor-targeted human telomerase reverse transcriptase promoter/tk gene therapy against human nasopharyngeal carcinoma cells in vitro].

Objective: To investigate the targeted killing effect of human telomerase reverse transcriptase promoter (hTERTp)/tk gene on human nasopharyngeal carcinoma (NPC) cells.

Methods: The recombinant plasmid hTERTp/tk/pGL3 was transfected into human NPC HNE1 cells and the expressions of TK and telomerase were investigated. The targeted killing effect induced by hTERTp/tk on HNE1 cells was assessed using RT-PCR and MTT assay.

[Long-term results of endolymphatic sac decompression and endolymphatic-mastoid shunting for Meniere's disease].

Objective: To investigate the efficacy of endolymphatic sac surgery for Meniere's disease, and compare the effects of endolymphatic sac decompression with endolymphatic-mastoid shunting.

Method: Twelve patients(13 ears) undergoing endolymphatic-mastoid shunting and eleven patients (11 ears) undergoing endolymphatic sac decompression were retrospectively compared for hearing results and vertigo controlled rates. All of them have been followed up for more than two years after surgery.

[Clinical analysis of 118 patients with tympanosclerosis].

Objective: To study the incidence of tympanosclerosis (TS) and the major risk factors of hearing loss.

Methods: A total of 118 TS patients (137 ears) were compared with 265 patients with chronic otitis media (COM) (311 ears) for gender, age and course of disease. The disease regions and hearing loss of the TS patients were analyzed.

Electrically evoked auditory nerve responses in the cochlea with normal outer hair cells.

As hybrid cochlear implant devices are increasingly used for restoring hearing in patients with residual hearing it is important to understand electrically evoked responses in cochleae having functional hair cells. To test the hypothesis that extracochlear electrical stimulation (EES) from sinusoidal current can provoke an auditory nerve response with normal frequency selectivity, the EES-evoked compound action potential (ECAP) was investigated in this study. Brief sinusoidal electrical currents, delivered via a round window electrode, were used to evoke ECAP.

[Experience of 76 cases of large vestibular aqueduct syndrome, clinical diagnosis and treatment].

Objective: To explore the disease incidence, clinical symptoms, prevention and treatment measures of the large vestibular aqueduct syndrome (LVAS).

Method: Retrospective analyse the medical history, hearing, vestibular function examination and treatment of 76 LVAS patients who were diagnosed in our department of Otolaryngology from 2002 to 2008.

Result: Most patients (93.

[Cochlear implant in patients with congenital malformation of the inner ear].

Objective: To summarize the clinical experience with multi-channel cochlear implantation in patients with inner ear malformations and evaluate and the outcomes of speech rehabilitation.

Methods: A retrospective study was conducted in 295 patients receiving cochlear implantation from 1998 to 2007, including 25 patients with large vestibular aqueduct syndrome (LVAS), 9 with Modini malformation, and 5 with common cavity deformity. All the patients received the Nucleus24 cochlear implants.

[Cochlear implantation in patients with large vestibular aqueduct syndrome].

Objective: To evaluate the hearing and speech recognition in patients with large vestibular aqueduct syndrome undergoing multi-channel cochlear implantation.

Methods: From 2005 to 2008, multi-channel cochlear implantation surgeries were performed in 22 patients with large vestibular aqueduct syndrome. All the patients received multi-channel cochlear implantation through transmastoid facial recess approach.

[Effect of surgical reconstruction of congenital aural atresia via the mastoid antrum approach: analysis of 48 cases].

Objective: To assess the effect of surgical reconstruction of congenital aural atresia via the mastoid antrum approach and investigate method for preventing postoperative atresia of the reconstructed aural canal.

Methods: From 2000 to 2008, aural canal reconstruction and tympanoplasty was performed via the mastoid antrum approach. In 48 patients with congenital aural atresia (54 ears, including 45 ears of type II, 9 ears of type III).

[Therapeutic effects of small fenestra stapedotomy with semiconductor diode laser: a comparison with microdrill].

Objective: To compare the effects of small fenestra stapedotomy with semiconductor diode laser and microdrill in patients with otosclerosis.

Methods: Twenty-six patients (29 ears) undergoing stapedotomy with semiconductor diode laser and 19 patients (21 ears) with microdrill were compared for the hearing results and complication rates.

Results: No statistically significant differences were found in postoperative speech frequency and high frequency pure tone average in closing the air-bone gap between the two groups.

[Therapeutic effect of insulin-like growth factor-1 injection into the inner ears through scala tympani fenestration on gentamicin-induced hearing loss in guinea pigs].

Objective: To study the therapeutic effect of insulin-like growth factor-1 (IGF-1) injection into the inner ears through a scala tympani fenestration on sensorineural deafness in a guinea pig model of gentamicin-induced hearing loss.

Methods: Twenty guinea pigs with gentamicin-induced hearing loss were randomized equally into IGF-1 group and control group. In both groups, scala tympani fenestration was performed for injection of IGF-1 (10 microl) or artificial perilymphatic fluid (10 microl).

[Auditory brainstem response in normal guinea pigs and those with gentamicin-induced hearing loss under awake and anesthetic conditions].

Objective: To observe the alterations of auditory brainstem response (ABR) in guinea pigs with gentamicin-induced hearing loss under awake and anesthetic conditions.

Methods: We recorded the ABR in 20 normal guinea pigs and 20 with gentamicin-induced hearing loss before and after anesthesia for statistical analysis.

Results: No significant difference was observed in the waveform, response threshold (RT), I and III peak latencies (PL), I-III interpeak latencies (IPL) of ABR between awake and anesthetic conditions in normal guinea pigs (P>0.

[Cat-scratch disease].

Objective: To study the etiology, epidemiology, clinical and pathological features, diagnose and treatment of cat-scratch disease(CSD).

Method: The clinical information of 1 case was reported and the literatures were also reviewed.

Result: Bartonella henselae was the primary pathogen of CSD.

[Role of ciliary neurotrophic factor in regeneration of severed facial nerve of cats].

Objective: To study the role of extrinsic (CNTF) in the regeneration of severed facial nerve in cats.

Method: The facial nerve in temporal bone of adult cats were severed and the severed ends were connected with CNTF or saline applied at the connection. Electrophysiological examination and immunocytochemistry were performed with immunoelectron microscope for morphological analysis at 2, 4 and 8 weeks after the operation.

[Down-regulation of telomerase and its RNA and apoptosis in the HNE1 cell line of nasopharyngeal carcinoma induced by retinoid].

Objective: To explore the down-regulation of telomerase as well as its RNA and apoptosis induced by retinoid acid.

Method: After HNE1 cell lines of NPC were incubated with 10(-5) mol of retinoid in 6 days, the expression of telomerase and its RNA and the apoptosis of HNE1 cell lines were detected respectively with TRAP PCR ELISA, RT-nested PCR, apoptosis indexes and trans-electron microscope.

Result: After 6 days when RA was added to the HNE1 cell line, the morphological change and suspending of HNE1 cells were found and the HNE1 cells reduced.