Metal-organic frameworks based on pyrazolates for the selective and efficient capture of formaldehyde.

Indoor air pollution is one of the major threads in developed countries, notably due to high concentrations of formaldehyde, a harmful molecule difficult to eliminate. Addressing this purification challenge while adhering to the principles of sustainable development requires the use of innovative, advanced sustainable materials. Here we show that by combining state-of-the-art spectroscopic techniques with density-functional theory molecular simulations, we have developed an advantageous mild chemisorption synergistic mechanism using porous metal (III or IV) pyrazole- di-carboxylate based metal-organic framework (MOF) to trap formaldehyde in a reversible manner, without incurring significant energy penalties for regeneration.

M2 polarization of tumor-associated macrophages is dependent on integrin β3 via peroxisome proliferator-activated receptor-γ up-regulation in breast cancer.

Macrophages are particularly abundant and play an important role throughout the tumor progression process, namely, tumor-associated macrophages (TAM) in the tumor microenvironment. TAM can be polarized to disparate functional phenotypes, the M1 and M2 macrophages. M1-like type macrophages are defined as pro-inflammatory cells involved in killing cancer cells, while M2-like type cells can specially promote tumor growth and metastasis, tissue remodeling and immunosuppression.

Metal-Organic Frameworks as advanced moisture sorbents for energy-efficient high temperature cooling.

Latent cooling load accounts for 30% of the total load of air-conditioning, and its proportion is even higher in many tropical and subtropical climates. Traditional vapour-compression air-conditioning (VCAC) has a low coefficient of performance (COP) due to the refrigeration dehumidification process, which often makes necessary a great deal of subsequent re-heating. Technologies using conventional desiccants or sorbents for indoor moisture control are even less competitive than VCAC due to their high regeneration temperature, long cycling time and bulky components.