Genome assembly of Stewartia sinensis reveals origin and evolution of orphan genes in Theaceae.

Orphan genes play crucial roles in diverse biological processes, but the evolutionary trajectories and functional divergence remain largely unexplored. The Theaceae family, including the economically and culturally important tea plant, offers a distinctive model to examine these aspects. Here, we integrated Nanopore long-read sequencing, Illumina short-read sequencing, and Hi-C methods to decode a pseudo-chromosomal genome assembly of Stewartia sinensis, from the earliest-diverging tribe of Theaceae, spanning 2.

Robust finite-time input-to-state stability via impulsive hybrid control for uncertain dynamical systems with disturbances.

This paper studies the robust finite-time input-to-state stability (R-FT-ISS) including robust finite-time stability (R-FTS) via impulsive hybrid control (IHC) for uncertain dynamical systems (UDS) with disturbances. The notions of robust GKL-stability, R-FT-ISS, and R-FTS are proposed. Time-based IHC (T-IHC) and state-based IHC (S-IHC) are proposed, respectively.

Expression complementation between fundamental biological pathways in Populus hybrid contributes to heterosis in cadmium (Cd) accumulation and tolerance.

To reveal the pattern of heterosis in cadmium (Cd) bio-accumulation of poplar and whether the heterosis can promote the phytoremediation efficiency of Cd-polluted soil, the poplar hybrid variety QB-5 (I-101 × 84K) and its female parent I-101 (Populus alba) and male parent 84K (P. alba × P. glandulosa) were employed in a hydroponic experiment and a field trial.

Effect of different modified potato starch on starch-based films containing ZIF-67@thymol.

Zeolite imidazolate framework-67 (ZIF-67) was used to encapsulate thymol (THY) to improve the properties of potato starch films. The effect of different modified potato starches (acetate starch (AS), hydroxypropyl di-starch phosphate (HDSP), oxidized hydroxypropyl starch (OHS), and acetylated di-starch phosphate (ADSP)) on the film properties was investigated. The results showed that the modified potato starch film had better water resistance, mechanical property, and water vapor barrier than the natural potato starch film.

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.

Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions. RNA 5-methylcytosine (mC) modification possesses dynamic and reversible nature, suggesting that activity of its methyltransferase NSUN2 is actively regulated. However, how NSUN2 activity is response to acidic condition in tumor microenvironment and then regulates cancer cell survival remain to be clarified.

USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53.

The de-ubiquitinase USP33 has been shown to possess either tumour-promoting or inhibitory effect on human cancer cells. However, all these findings are mainly based on in vitro cell culture models, and the in vivo evidence, which is more plausible to digest the functional role of USP33 in carcinogenic process, is still lacking. Here, we demonstrate that USP33 modulates DNA damage responses including cell cycle arrest and apoptosis induction through associating with p53.

Yiqi Liangxue Jiedu Prescription Inhibited the Canonical Wnt Pathway to Prevent Hepatocellular Precancerous Lesions.

Purpose: Yiqi Liangxue Jiedu prescription (YLJP), a Chinese medicine that is commonly used to prevent liver cancer and is authorized by a national patent (patent No. ZL202110889980.5) has a therapeutic effect on precancerous lesions; however, the underlying mechanism remains unclear.

The application of QCT in the prognostic assessment of mCRC undergoing first-line treatment based on bevacizumab.

Background: Bevacizumab induces muscle atrophy by changing the gene expression level of muscle tissue. Quantitative computed tomography (QCT) enables precise measurement of various body compositions, including muscle area.

Materials & Methods: A total of 102 patients with metastatic colorectal cancer (mCRC) undergoing first-line chemotherapy based on bevacizumab were enrolled at thirst Affiliated Hospital of the University of Science and Technology of China.

Structure-guided design and evaluation of CRM197-scaffolded vaccine targeting GnRH for animal immunocastration.

Immunocastration is a humane alternative to surgical castration for controlling population and estrous behaviors in animals. Gonadotropin-releasing hormone (GnRH), the pivotal initiating hormone of the hormonal cascade in mammals, is the optimal target for immunocastration vaccine development. Cognate antigen-mediated cross-linking of B cell receptors (BCRs) is a strong activation signal for B cells and is facilitated by repetitive surface organizations of antigens.

Controllable p-type doping and improved conductance of few-layer WSevia Lewis acid.

Manipulation of the electronic properties of layered transition-metal dichalcogenides (TMDs) is of fundamental significance for a wide range of electronic and optoelectronic applications. Surface charge transfer doping is considered to be a powerful technique to regulate the carrier density of TMDs. Herein, the controllable p-type surface modification of few-layer WSeby FeClLewis acid with different doping concentrations have been achieved.

A myeloid differentiation-like protein in partnership with Toll5 from the pest insect senses baculovirus infection.

Many types of viruses infect insects and other arthropods. In contrast, little is known about how arthropods sense viruses, although several innate immune pathways including Toll have antiviral functions. Large DNA viruses in the family are used to control a number of pest insects.

Effects of dietary supplementation with medicinal plant mixtures and immunostimulants on the immune response, antioxidant capacity, and hepatopancreatic health of Chinese mitten crab ().

Introduction: This study aimed to evaluate the efficiency of tea polyphenols (TP) and medicinal plant mixtures ( + , Bail + + ) combined with astaxanthin (AST), benzoic acid (BA), and yeast complex on the health status of .

Method: A total of 630 crabs (male crabs: 41.51 ± 1.

Quantum Chemistry Dataset with Ground- and Excited-state Properties of 450 Kilo Molecules.

Due to rapid advancements in deep learning techniques, the demand for large-volume high-quality datasets grows significantly in chemical research. We developed a quantum-chemistry database that includes 443,106 small organic molecules with sizes up to 10 heavy atoms including C, N, O, and F. Ground-state geometry optimizations and frequency calculations of all compounds were performed at the B3LYP/6-31G* level with the BJD3 dispersion correction, while the excited-state single-point calculations were conducted at the ωB97X-D/6-31G* level.

Phytoremediation efficiency of poplar hybrid varieties with diverse genetic backgrounds in soil contaminated by multiple toxic metals (Cd, Hg, Pb, and As).

Fifteen poplar varieties were used in a field trial to investigate the phytoremediation efficiency, stress resistance, and wood property of poplar hybrid varieties with diverse genetic backgrounds under the composite pollution of heavy metals. The coefficient of variation and clone repeatability for growth traits and Cd concentration were large. The Cd accumulation of poplar varieties 107 and QHQ reached 1.

Radio frequency drying on functional diversity of tiger nut flour: Effects on physicochemical, structural, and rheological properties.

Tiger nut (TN) is a valuable nutrient and gluten-free tuber. To achieve high-quality TN flour as functional ingredients in food, it is essential to develop effective drying technologies for TN. Five drying methods including natural drying (Control), hot-air drying (HD), radio frequency single drying (RFSD), RF assisted hot-air drying (RFHD), and RF- vacuum drying (RFVD) were selected and compared to determine their effects on physiochemical, structural, and rheological properties of TN flour.

Valorization of Corn Straw for Production of Glucose by Two-Step Depolymerization.

Depolymerization of the cellulose part in lignocellulose to glucose is a significant step for lignocellulose valorization. As one of the main by-products of agricultural biomass in crop-producing filed, valorization of corn straw has attracted considerable attention. In this study, a two-step depolymerizing strategy of high-pressure CO-HO pretreatment and oxidation-hydrolysis was applied for selective depolymerization of the cellulose component of corn straw to glucose production.

Development and application of mathematical modeling of thymol release from environmental-responsive potato starch active packaging films.

Traditional active packaging materials are easily affected by the environment, resulting in their inability to release active substances in specified quantities at specified times and locations. In this study, MCM-41 was used as a thymol (THY) carrier and added to the potato starch (PS) matrix to design an intelligent release active packaging film based on storage microenvironment. MCM-41 encapsulation improved thermal stability of THY.

Improvement of Performance of CZTSSe Solar Cells by the Synergistic Effect of Back Contact Modification and Ag Doping.

To improve the performance of CuZnSn(S,Se) solar cells, a strategy is proposed to improve the quality of absorber and back interface simultaneously by substituting V-doped Mo (Mo:V) for a conventional Mo back electrode and incorporating Ag into the CuZnSn(S,Se) (ACZTSSe) absorber in this work. Since p-type V-doped MoSe (MoSe:V) is formed in the site between the absorber and Mo:V during selenization, the conventional Mo/n-MoSe back contact is modified to Mo:V/p-MoSe:V, a back surface passivation field (BSPF) is established at the back interface, the band bending of MoSe:V is downward and that of bottom of the absorber is upward. Further investigation reveals that the back contact modification and Ag doping have a synergistic effect on inhibiting carrier recombination, decreasing series resistance and increasing shunt resistance, thereby leading to the PCE of device without antireflection coating increased from 8.

The health context paradox in the relationship between victimization, classroom bullying attitudes, and adolescent depression: An analysis based on the hlm model.

From the perspective of the health context paradox, this study examined the relationship between adolescent victimization and depression based on the diathesis-stress model and attribution theory using a nested model. A survey was conducted on 3743 Chinese adolescents using the Bullying & Victimization Scale, Rumination Scale, Beck Depression Inventory, and Bullying Attitude Scale. The results disclosed that victimization had a positive impact on depression, rumination played a mediating role between victimization and depression, and classroom anti-bullying attitudes heightened the correlation between victimization and developing depression as well as between victimization and engaging in rumination thinking.

Improvement of Efficiency in Kesterite Solar Cells by Intentionally Inserting a Thin MoS Layer into the Back Interface.

A Mo(S,Se) interfacial layer is formed inevitably and uncontrollably between the Mo electrode and CuZnSn(S,Se) (CZTSSe) absorber during the selenization process, which significantly influences the performance of CZTSSe solar cells. In this work, an ultrathin MoS layer is intentionally inserted into Mo/CZTSSe to reduce the recombination and thus optimize the interface quality. It is revealed that the absorber exhibits a continuous and compact morphology with bigger grains and remarkably without pinholes across the surface or cross-sectional regions after MoS modification.

Influential factors of depression: The impact of harsh parenting, school support, and rumination.

Building on Beck's cognitive model of depression, this study examined the link between harsh parenting and adolescent depression via rumination. In addition, this study examined the moderating effect of school support. A survey of 4991 high school students in China was conducted utilizing the Harsh Parenting Scale, Rumination Responses Scale, Beck Depression Inventory, and The Multidimensional Scale of Perceived Social Support.