Publications by authors named "Mengge Han"
Article Synopsis
- The study highlights the use of old yellow enzymes, particularly OYE3, for converting (/)-citral into enantio-pure ()-citronellal through asymmetric reduction.
- By modifying OYE3 using semi-rational design, specific variants (W116A and S296F) were created to improve enantioselectivity, effectively discriminating between different forms of citral.
- The best-performing variant, S296F/W116G, enabled a novel cascade reaction leading to the synthesis of ()-citronellal while preserving ()-citral, demonstrating an efficient method for producing enantiomerically pure compounds.
This secondary analysis was designed to evaluate the independent effect of physical activity (PA) on hemoglobin A1c (HbA1c) level in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 799 T2DM patients from eight communities of Shanghai, China, were randomized into one control arm and three intervention arms receiving 1-year interventions of health literacy, exercise, or both. PA was measured using the International Physical Activity Questionnaire at baseline, 12 months, and 24 months and quantified as metabolic equivalents (Mets).
View Article and Find Full Text PDFEvolution of non-communicable disease prevention and control in China.
Glob Health Promot
December 2019
The 70-year experience of China in fighting against non-communicable diseases (NCDs) can be classified into three distinct periods: 1) the disease-oriented strategy period (from 1950 to 1994); 2) the risk factor-focused strategy period (from 1995 to 2008); and 3) the social and policy priority strategy period (since 2009). A number of projects were successful and valuable experience and lessons were accumulated during the three periods. Due to the underestimation of the 'explosive' epidemic of NCDs, however, it took China quite a long time to find the right path to curb the upward trend in these diseases.
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