Network pharmacology, molecular docking, and untargeted metabolomics reveal molecular mechanisms of multi-targets effects of Qingfei Tongluo Plaster improving respiratory syncytial virus pneumonia.

Objective: Qingfei Tongluo Plaster (QFP), an improved Chinese medicine hospital preparation, is an attractive treatment option due to its well clinical efficacy, convenience, economy, and patient compliance in the treatment of respiratory syncytial virus (RSV) pneumonia. The aim of this study was to investigate the efficacy mechanism of QFP on RSV rats from the perspective of alleviating lung inflammation and further explore the changes of serum metabolites and metabolic pathways in RSV rats under the influence of QFP.

Methods: This study used network pharmacological methods and molecular docking combined with molecular biology and metabolomics from multi-dimensional perspectives to screen and verify the therapeutic targets.

Visible light induced hydroxyfluoroalkylation of quinoxalin-2(1)-ones with -trifluoroethoxyphthalimide under catalyst-free conditions.

For the first time, we achieved visible light-induced direct C3-hydroxyfluoroalkylation of quinoxalin-2(1)-ones using -trifluoroethoxyphthalimide as the trifluoroethanol radical precursor, without the need for a photocatalyst. The metal-free and catalyst-free nature of this method makes it an efficient and environmentally friendly approach for synthesizing C3-hydroxyfluoroalkylated quinoxalin-2(1)-ones.

Nature of the lunar far-side samples returned by the Chang'E-6 mission.

The Chang'E-6 (CE-6) mission successfully achieved return of the first samples from the far side of the Moon. The sampling site of CE-6 is located in the South Pole-Aitken (SPA) basin-the largest, deepest and oldest impact basin on the Moon. The 1935.

Melting and Rapid Solidification of Lunar Regolith Particles Returned by Chang'E-5 Mission.

Melting and solidification of lunar regolith are pivotal for comprehending the evolutionary dynamics of lunar volcanism, geology, and impact history. Additionally, insights gained from these processes can contribute to the advancement of in situ resource utilization technologies, for instance additive manufacturing and resource extraction systems. Herein, we conduct the direct observation of the melting and rapid solidification of lunar particles returned by the Chang'E 5 mission.

Comparative Analysis of the Nutritional Quality of Cultivars Harvested in Different Growing Seasons.

() is a popular aquatic vegetable with various nutrients in south China, but little is known about its cultivars and growing seasons in terms of the nutritional components. This work aims to characterize the nutrients of five cultivars in different growing seasons. The results showed that samples differed in terms of chemical parameters, which were significantly affected by variety, growing season, and their interaction.

The Difference in Diversity between Endophytic Microorganisms in White and Grey .

The is usually infected by the obligate parasitic fungus to form an edible fleshy stem which is an aquatic vegetable called Jiaobai in China. The infection by the teliospore (T) strain of induces forming gray fleshy stems, while the mycelia-teliospore (MT) strain of induces white fleshy stems which are more suitable for edibility than gray fleshy stems. The mechanism of this phenomenon is still largely unknown.

Diverse glasses revealed from Chang'E-5 lunar regolith.

Lunar glasses with different origins act as snapshots of their formation processes, providing a rich archive of the Moon's formation and evolution. Here, we reveal diverse glasses from Chang'E-5 (CE-5) lunar regolith, and clarify their physical origins of liquid quenching, vapor deposition and irradiation damage respectively. The series of quenched glasses, including rotation-featured particles, vesicular agglutinates and adhered melts, record multiple-scale impact events.

Geological timescales' aging effects of lunar glasses.

Physical aging is a long-lasting research hot spot in the glass community, yet its long-term effects remain unclear because of the limited experimental time. In this study, we discover the extraordinary aging effects in five typical lunar glassy particles with diameters ranging from about 20 to 53 micrometers selected from Chang'e-5 lunar regolith. It is found that geological time scales' aging can lead to unusually huge modulus enhancements larger than 73.

Possible molecular exploration of herbal pair Haizao-Kunbu in the treatment of Graves' disease by network pharmacology, molecular docking, and molecular dynamic analysis.

Objective: To promote the development and therapeutic application of new medications, it is crucial to conduct a thorough investigation into the mechanism by which the traditional Chinese herb pair of Haizao-Kunbu (HK) treats Graves' disease (GD).

Materials And Methods: Chemical ingredients of HK, putative target genes, and GD-associated genes were retrieved from online public databases. Using Cytoscape 3.

Diploid mycelia of fails to maintain sustainable proliferation in host plant.

Smut fungi display a uniform life cycle including two phases: a saprophytic phase and a parasitic phase in host plants. Several apathogenic smut fungi are found, lacking suitable hosts in their habitat. Interestingly, MT-type was found to maintain a parasitic life, lacking the saprophytic phase.

Tuning Electronic State and Charge Transport in B←N-Containing 2D Polymer Heterostructures with Efficient Photocatalytic Performance.

Linear-conjugated polymers (LCPs) are excellent semiconductor photocatalysts. However, its inherent amorphous structures and simple electron transport channels restrict efficient photoexcited charge separation and transfer. Herein, "2D conjugated engineering" is employed to design high-crystalline polymer photocatalysts with multichannel charge transport by introducing alkoxyphenyl sidechains.

Methanol steam reforming for hydrogen production over NiTiO nanocatalyst with hierarchical porous structure.

Steam reforming for hydrogen production is one of the important research directions for clean energy. NiTiO catalysts with a hierarchical porous structure are prepared and applied to methanol steam reforming for hydrogen production. The results show that the optimum catalyst (10% Ni-Ti-O) not only has a hierarchical porous structure, but it also involves the coexistence of NiTiO, anatase TiO and rutile TiO.

First Report of Leaf Sheath Disease, Caused by , on in China.

, which belongs to the tribe , has been widely grown over thousands of years as an aquatic vegetable in China. In the autumn of 2019, the disease harmful to the leaf sheaths of was found in Jinhua City and Lishui City, Zhejiang Province. The disease caused brown oval-shaped spots (3~5 cm long, 0.

Characteristics of the lunar samples returned by the Chang'E-5 mission.

Forty-five years after the Apollo and Luna missions returned lunar samples, China's Chang'E-5 (CE-5) mission collected new samples from the mid-latitude region in the northeastern Oceanus Procellarum of the Moon. Our study shows that 95% of CE-5 lunar soil sizes are found to be within the range of 1.40-9.

Cloning and disruption of the UeArginase in Ustilago esculenta: evidence for a role of arginine in its dimorphic transition.

Background: Ustilago esculenta, a typical dimorphic fungus could infect Zizania latifolia and induce host stem swollen to form an edible vegetable called Jiaobai in China. The strains differentiation especially in the mating ability and pathogenicity is closely related to different phenotypes of Jiaobai formed in the fields. Dimorphic switching, a tightly regulated processes, is essential for the pathogenetic development of dimorphic fungi.

Overexpression of rice LRK1 restricts internode elongation by down-regulating OsKO2.

Rice (Oryza sativa) has the potential to undergo rapid internodal elongation which determines plant height. Gibberellin is involved in internode elongation. Leucine-rich repeat receptor-like kinases (LRR-RLKs) are the largest subfamily of transmembrane receptor-like kinases in plants.

Over-expression of the rice LRK1 gene improves quantitative yield components.

In rice (Oryza sativa L.), the number of panicles, spikelets per panicle and grain weight are important components of grain yield. These characteristics are controlled by quantitative trait loci (QTLs) and are derived from variation inherent in crops.