Inhibition of migration and invasion by berberine via inactivation of PI3K/Akt and p38 in human retinoblastoma cell line.

Background: As a clinically important natural isoquinoline alkaloid, berberine has been reported to possess various pharmacological effects.

Objectives: This study was aimed to investigate the effect of berberine on cell migration and invasion in human retinoblastoma (Rb) cells.

Material And Methods: The cytotoxicity of berberine was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay.