X-ray Cherenkov-luminescence tomography reconstruction with a three-component deep learning algorithm: Swin transformer, convolutional neural network, and locality module.

Significance: X-ray Cherenkov-luminescence tomography (XCLT) produces fast emission data from megavoltage (MV) x-ray scanning, in which the excitation location of molecules within tissue is reconstructed. However standard filtered backprojection (FBP) algorithms for XCLT sinogram reconstruction can suffer from insufficient data due to dose limitations, so there are limits in the reconstruction quality with some artifacts. We report a deep learning algorithm for XCLT with high image quality and improved quantitative accuracy.