Palladium-catalyzed C-H bond activation and decarboxylation for the assembly of indolo[1,2-]phenanthridine.

A direct and convenient strategy for the assembly of indolo[1,2-]phenanthridine a Pd-catalyzed tandem cyclization reaction is presented. The current strategy delivers a range of indolo[1,2-]phenanthridine derivatives by utilizing readily available 1-(2-iodophenyl)-1-indole and commercially available -bromobenzoic acids as the starting materials. The reaction features the formation of two C-C bonds through Pd-catalyzed C-H bond activation and decarboxylation.

Landscape of Digital Technologies Used in the National Health Service in England: Content Analysis.

Background: In England, digital technologies are exploited to transform the way health and social care is provided and encompass a wide range of hardware devices and software that are used in all aspects of health care. However, little is known about the extent to which health care providers differ in digital health technology capabilities and how this relates to geographical and regional differences in health care capacities and resources.

Objective: This paper aims to identify the set of digital technologies that have been deployed by the National Health Services clinical commissioning groups (NHS CCGs) in England.

A Framework for Evaluating Dashboards in Healthcare.

In the era of 'information overload', effective information provision is essential for enabling rapid response and critical decision making. In making sense of diverse information sources, dashboards have become an indispensable tool, providing fast, effective, adaptable, and personalized access to information for professionals and the general public alike. However, these objectives place heavy requirements on dashboards as information systems in usability and effective design.

Household visitation during the COVID-19 pandemic.

The COVID-19 pandemic has posed novel risks related to the indoor mixing of individuals from different households and challenged policymakers to adequately regulate this behaviour. While in many cases household visits are necessary for the purpose of social care, they have been linked to broadening community transmission of the virus. In this study we propose a novel, privacy-preserving framework for the measurement of household visitation at national and regional scales, making use of passively collected mobility data.

Digital technologies in the public-health response to COVID-19.

Digital technologies are being harnessed to support the public-health response to COVID-19 worldwide, including population surveillance, case identification, contact tracing and evaluation of interventions on the basis of mobility data and communication with the public. These rapid responses leverage billions of mobile phones, large online datasets, connected devices, relatively low-cost computing resources and advances in machine learning and natural language processing. This Review aims to capture the breadth of digital innovations for the public-health response to COVID-19 worldwide and their limitations, and barriers to their implementation, including legal, ethical and privacy barriers, as well as organizational and workforce barriers.