Publications by authors named "Mengdie Xue"
Background: Mitochondrial dysfunction is a key factor in the development of atherogenesis. METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA). However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown.
View Article and Find Full Text PDFBackground And Aims: Vascular smooth muscle cell (VSMC) senescence is crucial for the development of atherosclerosis, characterized by metabolic abnormalities. Tumour necrosis factor receptor-associated protein 1 (TRAP1), a metabolic regulator associated with ageing, might be implicated in atherosclerosis. As the role of TRAP1 in atherosclerosis remains elusive, this study aimed to examine the function of TRAP1 in VSMC senescence and atherosclerosis.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how nanoparticles (NPs) enter biological cells, which is significant for drug delivery.
- It highlights that while previous research has looked at properties of NPs and ligands, the connection between how ligands are attached to NPs and their uptake by cells has been largely ignored.
- Using gold nanoparticles as an example, the research shows that stronger bonds and more mobile ligands increase NP uptake efficiency, and this also influences the pathway through which NPs are internalized by cells.
The protein corona effect has long been treated as the evil source behind delivery efficacy issues. In this study, this concept is challenged by showcasing that the protein corona can serve as a versatile functionalization approach to improve the delivery efficacy or mitigate nanocytotoxicity. To this end, the depleted serum is introduced to create nanomaterials carrying functionally distinct protein corona, referred to as PCylated nanomaterials.
View Article and Find Full Text PDF