Zinc finger proteins facilitate adaptation of a global insect pest to climate change.

Background: Global climate change significantly impacts ecosystems, particularly through temperature fluctuations that affect insect physiology and behavior. As poikilotherms, insect pests such as the globally devastating diamondback moth (DBM), Plutella xylostella, are especially vulnerable to rising temperatures and extreme heat events, necessitating effective adaptive mechanisms.

Results: Here we demonstrate the roles of zinc finger proteins (ZFPs) in mediating thermal adaptability in DBM.

A novel photocatalytic system coupling metal-free Carbon/g-CN catalyst with persulfate for highly efficient degradation of organic pollutants.

A variety of photocatalytic systems have emerged as the effective methods for the degradation of organic pollutants. In this research, a novel photocatalytic system, named CNC-PDS has been proposed, which couples a metal-free carbon/g-CN (CNC) photocatalyst with persulfate (PDS), and applied for efficient degradation of paracetamol (PCM) under simulated sunlight. The CNC-PDS system exhibited excellent photocatalytic capability, where the PCM was completely degraded in 40 min under simulated sunlight.

Sotetsuflavone ameliorates Crohn's disease-like colitis by inhibiting M1 macrophage-induced intestinal barrier damage via JNK and MAPK signalling.

Objectives: Intestinal inflammation and intestinal barrier dysfunction are two important pathological changes in Crohn's disease (CD). Sotetsuflavone (SF) is a natural monomeric herbal compound with anti-inflammatory and cytoprotective effects that is mostly nontoxic. The effect of SF on CD-like spontaneous colitis was investigated in this study.

Microbiota from patients with ulcerative colitis promote colorectal carcinogenesis in mice.

Objectives: Long-term ulcerative colitis (UC) is associated with both dysbiosis in intestinal microbiota and predisposition to colorectal cancer. In this study, we investigated whether microbiota from patients with UC could increase colorectal carcinogenesis in mice, generated by azoxymethane through intraperitoneal injection.

Methods: Mice were gavaged twice per week with intestinal microbiota from patients with UC or healthy individuals.

gCN-P: a coupled g-CN/persulfate system for photocatalytic degradation of organic pollutants under simulated sunlight.

A coupled g-CN/PDS system, named gCN-P, has been put forward to degrade refractory organic pollutants under simulated sunlight which integrates photocatalysis and PS-AOPs (advanced oxidation of persulfate based on sulfate radicals). The coupled g-CN and PDS showed superior synergistic effect for MO degradation under simulated sunlight. Results showed that almost all MO was removed in the gCN-P system after irradiation for 80 min under simulated sunlight.

A Two-Stage Hybrid Default Discriminant Model Based on Deep Forest.

the credit scoring model is an effective tool for banks and other financial institutions to distinguish potential default borrowers. The credit scoring model represented by machine learning methods such as deep learning performs well in terms of the accuracy of default discrimination, but the model itself also has many shortcomings such as many hyperparameters and large dependence on big data. There is still a lot of room to improve its interpretability and robustness.

Clematichinenoside AR ameliorated spontaneous colitis in Il-10 mice associated with improving the intestinal barrier function and abnormal immune responses.

Objectives: Clematichinenoside AR (AR) is a saponin extracted for traditional Chinese medicine with the effects of improving the expression of tight junction (TJ) proteins and mediating anti-inflammatory activities. However, its effect on Crohn's disease (CD) is still unknown. We aimed to investigate the impact of AR on CD-like colitis and determine the mechanism underlying its effects.

Bryostatin-1 ameliorated experimental colitis in Il-10 Mice by protecting the intestinal barrier and limiting immune dysfunction.

Bryostatin-1 (Bry-1) has been proven to be effective and safe in clinical trials of a variety of immune-related diseases. However, little is known about its effect on Crohn's disease (CD). We aimed to investigate the impact of Bry-1 on CD-like colitis and determine the mechanism underlying this effect.

[IL-12 monoclonal antibody alleviates intestinal inflammation in IL-10 mice by regulating intestinal mucosal immunity].

Objective To evaluate the therapeutic effect and possible mechanism of IL-12 monoclonal antibody (IL-12 mAb) on IL-10 knockout(IL-10) mice and its possible mechanism. Methods Sixteen male IL-10 mice of 15 weeks old were randomly divided into control group and IL-12 mAb treatment group. The IL-12 mAb treatment group were given intraperitoneal injection of IL-12 mAb (25 mg/kg, once per week), and the control group was given intraperitoneal injection of 0.