Publications by authors named "Mengdan Dong"
Morphological and transcriptional analysis of sexual differentiation and gonadal development in a burrowing fish, the four-eyed sleeper (Bostrychus sinensis).
Comp Biochem Physiol Part D Genomics Proteomics
December 2023
Article Synopsis
- The study focuses on the four-eyed sleeper fish, a commercially important species, exploring the advantages of producing all-male progeny for economic gain.
- Researchers investigated the stages of gonadal development and identified crucial time points for sexual differentiation, especially in germ stem cells.
- Transcriptome analysis uncovered key genes and signaling pathways related to sexual differentiation, laying the groundwork for potential sex-control strategies in aquaculture.
Article Synopsis
- The study explores the potential of creating functional sperm from spermatogonia in marine four-eyed sleepers to enhance reproduction and genetic breeding in aquaculture fish with long generation times.
- Researchers successfully induced spermatogonia to develop into flagellated sperm using a three-dimensional culture system, demonstrating that these sperm can fertilize oocytes and produce healthy larvae.
- The addition of melatonin improved the production of functional sperm by promoting spermatogonia growth and differentiation, utilizing the ERK1/2 signaling pathway, indicating a promising method for advancing aquaculture practices.
CXC Chemokine signaling plays an important role in wound healing. The four-eyed sleeper () is a commercially important marine fish, which is prone to suffer skin ulceration at high temperature seasons, leading to mass mortality of fish in aquaculture farms. The genetic background related to skin ulceration and wound healing has remained unknown in this fish.
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