Publications by authors named "Mengchao Zhu"
Objectives: To identify factors associated with progressive anisometropia after bilateral intraocular lens (IOL) implantation in patients with pediatric cataract.
Methods: Clinical and standardized questionnaire data were collected for Sixty-eight patients with pediatric cataract (136 eyes) who underwent bilateral IOL implantation and at least 1 year of follow-up. Univariate and multivariate linear regression models were used to identify factors associated with postoperative anisometropia.
Background: Autophagy is an important process that maintains the quality of intracellular proteins and organelles. There is extensive evidence that autophagy has an important role in the lens. Human lens epithelial cells (HLECs) play a key role in the internal homeostasis of the lens.
View Article and Find Full Text PDFAim: To identify metabolites, proteins, and related pathways involved in the etiology of rhegmatogenous retinal detachment (RRD) for use as biomarkers in diagnosing and treating RRD.
Methods: Vitreous specimens were collected and liquid chromatography-tandem mass spectrometry analysis was performed using the four-dimensional label-free technique. Statistically significant differentially expressed proteins, gene ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway representations, and protein interactions were analyzed.
Article Synopsis
- Researchers used single-cell RNA sequencing to analyze 18,596 cells from the human lens, uncovering two subtypes of lens epithelial cells that are distinguished by specific gene expressions (C8orf4 and ADAMTSL4).
- They discovered a new type of fiber cells near the epithelium and identified a potential subpopulation of lens epithelial stem/progenitor cells.
- The study also revealed two pathways for lens epithelial cell differentiation, highlighting significant gene changes occurring during this process.
This study aimed to investigate the capsule-epithelium-fibre unit ultrastructure of the human lens, particularly the interfaces of the epithelium with the capsule and the epithelium with the fibre cell. A total of 12 lenses from donor humans who died of trauma without systemic and ocular diseases were investigated by transmission electron microscopy (TEM), combined with immunofluorescence staining for localising certain specific proteins. Some of the results were further studied in the anterior lens capsules of cataract patients.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates the relationship between sugar intake, glycemic control, and myopia (nearsightedness), aiming to clarify conflicting previous findings.
- - Using a two-sample Mendelian randomization approach, researchers analyzed six glycemic traits, finding significant associations between low levels of adiponectin and high levels of HbA1c with increased risk of myopia.
- - The findings suggest that managing blood sugar levels through diet and physical activity could potentially help delay the onset of myopia in individuals.