Publications by authors named "MengYu Liu"

Background: Cervical cancer (CC), primarily caused by human papillomavirus (HPV) infection, remains a significant global health concern. We aimed to comprehensively investigate the epidemiological status of HPV in China.

Methods: Data from 2,728,321 women undergoing routine cervical examinations at 2127 medical institutions nationwide from January 2017 to June 2023 were analyzed.

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To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed a collection of candidate genes located in 30 genomic loci under positive selection. Among them, MCUR1 at 6p23 was a novel pronounced candidate.

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Ursodeoxycholic acid (UDCA) can be used as a drug to treat various liver and bile diseases. Currently, the biological synthesis of UDCA is predominantly conducted via a two-step enzymatic process in which synthesis is catalyzed by 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) in succession, utilizing chenodeoxycholic acid (CDCA) as the substrate. In this study, an engineered () strain, designated UCA23, was constructed.

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Lithium-sulfur (Li-S) batteries have attracted significant attention due to their high theoretical energy density, low cost and environmental friendliness, which are considered one of the most promising candidates for next-generation energy storage devices. However, the sluggish kinetics associated with sulfur oxidation-reduction reactions and the detrimental shuttle effect caused by lithium polysulfides (LiPSs) significantly impacts the electrochemical performance of Li-S batteries. In this work, Co single-atom catalyst (Co-NC) on an ordered macro-microporous structure are designed, and the catalyst are coated onto 2325 separator.

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This study aimed to compare the bioactive compounds presented in quinoa of various colors, and investigated their inhibitory effect on α-glucosidase activity and the in vitro digestibility of starch. The primary bioactive compounds identified in quinoa included betaine and polyphenols (kaempferol, quercetin, rutin, etc.), with their contents increased as the color of quinoa darkened.

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Reduced lymphoid enhancer-binding factor 1 (LEF1) expression in patients with adenomyosis during the mid-secretory phase leads to impaired endometrial receptivity, affecting embryo implantation. This study investigated the molecular mechanisms underlying reduced endometrial receptivity in 25 adenomyosis patients and 25 controls. Functional experiments were conducted using human endometrial stromal cells (HESCs) and TERT-immortalized HESCs(T-HESCs), with final validation performed using a mouse model.

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Background: Post-stroke depression (PSD) is the most prevalent neuropsychiatric complication following a stroke. The inflammatory theory suggests that PSD may be associated with an overactive inflammatory response. However, research findings regarding inflammation-related indicators in PSD remain inconsistent and elusive.

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Percutaneous coronary intervention (PCI) is a practical and effective method for treating coronary heart disease (CHD). This study aims to explore the influencing factors of major cardiovascular events (MACEs) and hospital readmission risk within one year following PCI treatment. Additionally, it seeks to assess the clinical value of Apolipoprotein B/Apolipoprotein A-I (ApoB/ApoA-I) in predicting the risk of one-year MACEs and readmission post-PCI.

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A self-driven electrochemical system (SDES) was utilized to treat anaerobic digestate wastewater, aiming to achieve wastewater resource utilization and energy generation. The efficiencies of pollutant removal, resource recovery, and energy production were enhanced by adjusting device parameters (anode area, external resistance, and electrode spacing). The high pollutant removal rates and struvite purity were achieved with the magnesium anode area of 15 cm, external resistance of 10 Ω, and electrode spacing of 10 cm.

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An integrated magnetoimpedance (MI) biosensor microfluidic magnetic platform was proposed for the evaluation of the cardiac marker, cardiac troponin I (cTnI). This bioanalyte evaluation platform mainly comprised three external permanent magnets (PMs), one MI element, two peelable SiO film units and a microfluidic chip (MFC). The MI element was made of micro-electro-mechanical system (MEMS)-based multilayered [Ti (6 nm)/FeNi (100 nm)]/Cu (400 nm)/[Ti (6 nm)/FeNi (100 nm)] thin films and designed as meander structures with closed magnetic flux.

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Ferroptosis, a non-apoptotic form of cell death characterized by the production of reactive oxygen species (ROS) and massive accumulation of lipid peroxidation (LPO), shows significant promise in cancer therapy. However, the overexpression of glutathione (GSH) at the tumor site and insufficient ROS often result in unsatisfactory therapeutic efficacy. A multistage, GSH-consuming, and ROS-providing carrier-free nanodrug capable of efficiently loading copper ions (Cu), sorafenib (SRF), and chlorogenic acid (CGA) (Cu-CGA-SRF, CCS-NDs) is developed to mediate enhanced ferroptosis therapy.

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Vitamin D binding protein (VDBP) is a potential biomarker of major depressive disorder (MDD). This study demonstrates for the first time that VDBP is highly expressed in core emotion-related brain regions of mice susceptible to chronic unpredictable mild stress (CUMS). Specifically, the overexpression of microglia (MG)-derived VDBP in the prelimbic leads to depression-like behavior and aggravates CUMS-induced depressive phenotypes in mice, whereas conditional knockout of MG-derived VDBP can reverse both neuronal damage and depression-like behaviors.

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Endosomes are crucial sites for intracellular material sorting and transportation. Endosomal transport is a critical process involved in the selective uptake, processing, and intracellular transport of substances. The equilibrium between endocytosis and circulation mediated by the endosome-centered transport pathway plays a significant role in cell homeostasis, signal transduction, and immune response.

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A catalyst-free reductive radical-polar crossover cyclization with alkenes and sodium dithionite to construct densely functionalized cyclic sultines was described. The key to the success of this practical protocol relies not only on a bifunctional role of sodium dithionite, that is, serving as radical initiator and SO source, but also on the diversified conversions (RPCC/SO insertion/S2 cyclization and RPCC/SO insertion/1,4-addition cyclization processes), which enabled efficient construction of target compounds with the high efficiency and atom- and step-economy under mild conditions.

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To address the challenge of preserving fresh chestnuts, chitosan (CS), hydroxypropyl methylcellulose (HPMC), nisin (N), and sodium alginate (SA) were utilized in the preparation of a bilayer edible film named CS-HPMC-N/SA, which was compared to the monolayer films CS-HPMC and CS-HPMC-N. In comparison to the CS-HPMC film, the CS-HPMC-N and CS-HPMC-N/SA films exhibited increased water vapor permeability (WVP), oxygen permeability, and thickness, while transparency, tensile strength (TS), and elongation at break (EAB) were reduced. The bilayer film CS-HPMC-N/SA showed higher WVP, transparency, thickness, and EAB, but lower TS than the monolayer film CS-HPMC-N.

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Article Synopsis
  • To combat plastic pollution from polyethylene film mulch in agriculture, biodegradable plastic films are being researched as an eco-friendly alternative, although their effect on soil carbon is still uncertain.
  • A field study was conducted comparing the impacts of different types of microplastics (biodegradable PBAT and traditional LDPE) on soil properties while growing soybeans, measuring factors like soil respiration and organic carbon content.
  • Results indicated that different microplastics had varying effects on soil respiration and carbon fractions; while PBAT debris enhanced soil carbon levels, LDPE reduced them, suggesting that biodegradable films could benefit soil health and carbon sequestration efforts in agriculture.
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A crystalline@amorphous MnO (HT@RT) plasma catalyst was successfully constructed in this study to address the problem of odor pollution, especially from volatile organic sulfur compounds (VOSCs) with low olfactory thresholds. Complete conversion of dimethyl sulfide (DMS) at 140 J/L was achieved, and the ozone concentration in the exhaust gas was maintained below 5 ppm. Deeper mineralization of DMS was achieved in the HT@RT sample than in the individual HT and RT samples.

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The novel inflammatory markers neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immunoinflammatory index (SII) have not yet been used in the study of age-related cataracts. The aim of this study was to investigate the possible relationships between the NLR, PLR, and SII and age-related cataracts. In the 2005-2008 National Health and Nutrition Examination Survey (NHANES) cross-sectional surveys, we collected complete information on blood counts, whether cataract surgery had been performed, and baseline information for adults.

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An organocatalytic asymmetric vinylogous Michael/oxa-Michael tandem reaction between β,γ-unsaturated pyrazoleamides and isatin-derived β,γ-unsaturated ketoesters has been developed with excellent regio-, diastereo-, and enantioselectivities. The methodology provides an effective approach to construct enantiomerically pure 3,4'-pyranyl spirooxindole derivatives containing three contiguous chiral centers. Moreover, the transformations of the chiral products, including the removal and reduction of the pyrazole group, have been investigated.

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Article Synopsis
  • * Researchers analyzed 1,127 older adults, identifying two metabolites—2-oxoglutarate and malate—that were significantly associated with increased hypertension risk, even after adjusting for other factors.
  • * The findings suggest that these metabolites could serve as potential markers for hypertension diagnosis; however, more extensive future studies are needed to validate these results.
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Article Synopsis
  • * There are two main ways to produce D-allulose: chemical synthesis, which can create unwanted byproducts, and biosynthesis, which uses enzymes to convert starch or glycerol into D-allulose more efficiently.
  • * The article reviews recent research on biosynthesis, highlighting the enzymes used, their properties, and the potential for improved production methods for D-allulose.
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High-fat diet (HFD) induced obesity is associated with depression-related behavioral and neurogenic changes and may lead to cognitive impairment. Fluoxetine (FXT), the most commonly used antidepressant, may alleviate depressive symptoms by increasing neurogenesis, but the potential efficacy of FXT for HFD-induced cognitive deficits is unclear. In this study, we established an obese HFD mouse model by feeding three-week-old male C57BL/6N mice with a chronic HFD for 18 weeks, then assessed adipose tissue morphology by magnetic resonance imaging and histopathology, assessed cognitive function by Morris water maze and novel object recognition tests, and detected DCX and BrdU expression in the hippocampal dentate gyrus (DG) region by immunofluorescence bioassay.

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Soybean is an important plant source of protein worldwide. Increasing demands for soybean can be met by improving the quality of its seed protein. In this study, GmCG-1, which encodes the β-conglycinin α' subunit, was identified via combined genome-wide association study and transcriptome analysis.

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Background: As a novel type of extracellular polysaccharide produced by Sphingomonas sp., welan gum has been widely applied in various fields because of its excellent properties. The study has improved the fermentation process.

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Article Synopsis
  • Developing effective drug delivery systems for deep tumor penetration is crucial in cancer treatment, and using tumor-derived extracellular vesicles (EVs) is a promising approach.
  • A novel method was created to attach anti-tumor drugs to EVs using an engineered cell membrane vector that includes components for specific targeting and drug stability.
  • This strategy allows for the efficient transfer of therapeutic agents like photosensitizers deep into tumors, enhancing the effectiveness of phototherapy.
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