Research progress on the impact of intratumoral microbiota on the immune microenvironment of malignant tumors and its role in immunotherapy.

Microbiota has been closely related to human beings, whose role in tumor development has also been widely investigated. However, previous studies have mainly focused on the gut, oral, and/or skin microbiota. In recent years, the study of intratumoral microbiota has become a hot topic in tumor-concerning studies.

Zirconium Oxide Doped Organosilica Nanodots as Light- and Charge-Management Cathode Interlayer for Highly Efficient and Stable Inverted Organic Solar Cells.

In this work, it is reported that zirconium oxide (ZrO) doped organosilica nanodots (OSiNDs: ZrO) with light- and charge-management properties serve as efficient cathode interlayers for high-efficiency inverted organic solar cells (i-OSCs). ZrO doping effectively improves the light harvesting of the active layer, the physical contact between the active layer, as well as the electron collection property by habiting charge recombination loss. Consequently, all devices utilizing the OSiNDs: ZrO cathode interlayer exhibit enhanced power conversion efficiency (PCE).

Rich-grain-boundary Ni-Co-Se nanowire arrays for fast charge storage in alkaline electrolyte.

In this work, the one-dimensional (1D) Ni-Co-Se nanowire arrays with rich grain-boundaries were prepared through the solvothermal method and gas-phase selenizaiton. The results showed that the structure and crystallization of the Ni-Co-Se nanowire arrays could be modulated through the optimization of selenizaiton time. The optimal Ni-Co-Se electrode sample displayed an area specific capacitance of 242.

Achieving High-Performance Self-Powered Visible-Blind Ultraviolet Photodetection Using Alloy Engineering.

The exploration and development of self-powered visible-blind ultraviolet photodetectors (VBUV PDs) with high responsivity and wavelength selectivity have far-reaching significance for versatile applications. Although InO shows potential for UV detection due to good UV absorption and electrical transport properties, the poor wavelength selectivity impedes further application in VBUV PDs. Here, a self-powered photoelectrochemical-type (PEC) VBUV PD is demonstrated by using gallium-indium oxide alloys (Ga-In OAs).

Oxygen-vacancy-dependent high-performance-GaOnanorods photoelectrochemical deep UV photodetectors.

GaOis a good candidate for deep ultraviolet photodetectors due to its wide-bandgap, good chemical, and thermal stability. GaO-based photoelectrochemical (PEC) photodetectors attract increasing attention due to the simple fabrication and self-powered capability, but the corresponding photoresponse is still inferior. In this paper, the oxygen vacancy (V) engineering towards-GaOwas proposed to obtain high-performance PEC photodetectors.

Exogenous Thymosin Beta 4 Suppresses IPF-Lung Cancer in Mice: Possibly Associated with Its Inhibitory Effect on the JAK2/STAT3 Signaling Pathway.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. At present, the mortality rate of the deadly disease is still very high, while the existing treatments only delay the progression of the disease and improve the quality of life of patients. Lung cancer (LC) is the most fatal disease in the world.

MOF-Derived InO Microrods for High-Performance Photoelectrochemical Ultraviolet Photodetectors.

Ultraviolet photodetectors (UV PDs) have attracted extensive attention owing to their wide applications, such as optical communication, missile tracking, and fire warning. Wide-bandgap metal-oxide semiconductor materials have become the focus of high-performance UV PD development owing to their unique photoelectric properties and good stability. Compared with other wide-bandgap materials, studies on indium oxide (InO)-based photoelectrochemical (PEC) UV PDs are rare.

Boosting Photoresponse of Self-Powered InSe-Based Photoelectrochemical Photodetectors via Suppression of Interface Doping.

Two-dimensional (2D) InSe is a good candidate for high-performance photodetectors due to its good light absorption and electrical transport properties. However, 2D InSe photodetectors usually endure a large driving voltage, and 2D InSe-based heterojunction photodetectors require complex fabrication processes. Here, we demonstrate high-performance self-powered InSe-based photoelectrochemical (PEC) photodetectors using electrochemical intercalated ultrathin InSe nanosheets.

Salmonella typhimurium strip based on the photothermal effect and catalytic color overlap of PB@Au nanocomposite.

This work reports a sensitive and accurate multimode detection method to detect Salmonella typhimurium using inherent color, photothermal and catalytic properties of Prussian blue@gold nanoparticles (PB@Au). The inherent color of PB@Au can realize direct visual detection while the temperature increase (ΔT) of it can realize sensitive and quantitative photothermal detection. Moreover, catalytic coloration detection is applied to further amplify detection signal.

Adjusting grain boundary within NiCoOrod arrays by phosphating reaction for efficient hydrogen production.

In this work, the density and electronic structures of the metal active sites in NiCoOnanorod arrays were concurrently tuned by controlling the sample's exposure time in a phosphorization process. The results showed that both the density and electronic structure of the active adsorption sites played a key role towards the catalytic activity for water splitting to produce hydrogen. The optimal catalyst exhibited 81 mV overpotential for hydrogen evolution reaction (HER) at 10 mA cmand 313 mV overpotential towards oxygen evolution reaction at 50 mA cm.

Roughening the surface of porous NiCoP rod-like arrays the growth of NiCoPO nanoislands enables highly efficient energy storage.

In this study, a porous structure was initially constructed in the primitives of NiCoP electrode array nanorods based on the principle of the Kirkendall effect, and then phosphate particles generated by an oxidation process were attached to the surface. In the tri-electrode system, the specific capacity was increased to 0.9583 mA h cm with a current density of 2 mA cm.

Myricetin reverses epithelial-endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1.

Most antiangiogenic inhibitors targeting endothelium-dependent vessels cannot inhibit tumor growth but promote tumor invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct endothelium-dependent vessels. Inhibiting VM may be a novel antiangiogenic strategy against alternative tumor vascularization.

High-Performance Broadband Photoelectrochemical Photodetectors Based on Ultrathin BiOS Nanosheets.

Two-dimensional (2D) bismuth oxychalcogenide (BiOX, X refers to S, Se, and Te) is one type of rising semiconductor with excellent electrical transport properties, high photoresponse, and good air stability. However, the research on 2D BiOS is limited. In this work, ultrathin BiOS nanosheets are synthesized by a facile and eco-friendly chemical synthesis method at room temperature.

Exploring the interaction mechanism between antagonist and the jasmonate receptor complex by molecular dynamics simulation.

Jasmonates induce the protein-protein interaction between the F-box protein CORONATINE INSENSITIVE 1 (COI1) and jasmonate ZIM-domain proteins (JAZs) in the presence of inositol phosphate, which made the degradation of JAZs and the release of the JAZ-repressed transcription factors. They are involved in the regulation of a wide range of physiology process, including plant growth, development and stress response. Coronatine-O-methyloxime (COR-MO) prevents the binding of COI1-JAZ, acting as an antagonist for jasmonate signaling pathway, while the understanding on the molecular basis of its action as an antagonist is still lacking at atomic level.

Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting M and Sepsis in Mice.

The emergence of severe acute syndrome coronavirus 2 (SARS-CoV-2) in December 2019 has led to the global COVID-19 pandemic. Although the symptoms of most COVID-19 patients are mild or self-curable, most of severe patients have sepsis caused by cytokine storms, which greatly increases the case fatality rate. Moreover, there is no effective drug that can limit the novel coronavirus thus far, so it is more needed to develop antiviral drugs for the SARS-CoV-2.

Micro-controlling of the grain boundaries in NiCoO/NiCoS nanowires for enhanced charge storage.

In this work, the micro-controlling of the grain boundaries in NiCoO/NiCoS nanowire arrays was achieved by exposing them to a sulfur containing atmosphere at 300 °C with different exposure times. The results showed that the capacitance of the optimal NiCoS sample reached 400 μA h cm at 30 mA cm with a current retention rate of 58.6%.

Discovery and Verification of Key Liver Cancer Genes and Alternative Splicing Events Based on Second-Generation Sequencing Data Analysis.

Hepatocellular carcinoma (HCC) is the most common malignant liver disease in the world. Existing screening and early diagnosis methods are not highly sensitive for HCC, and patients are likely to develop the disease to the middle and advanced stages before being diagnosed. Therefore, finding new and efficient diagnosis and treatment methods has become an urgent problem.

Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells and .

Histone deacetylases (HDACs) exhibit increased expression in cancer and promote oncogenesis via the acetylation of or interactions with key transcriptional regulators. HDAC inhibitors (HDACis) decrease HDAC activity to selectively inhibit the occurrence and development of tumors. Our study screened and obtained a new HDACi structure.

Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis.

Background: COVID-19 (Coronavirus Disease-2019) has spread widely around the world and impacted human health for millions. The lack of effective targeted drugs and vaccines forces scientific world to search for new effective antiviral therapeutic drugs. It has reported that flavonoids have potential inhibitory activity on SARS-CoV-2 M and anti-inflammatory properties.

Performance Enhancement of Organic Solar Cells by Adding a Liquid Crystalline Molecule in Cathode and Anode Interlayers.

In this study, an effective and simple approach for optimizing the performance of both cathode and anode interlayers in OSCs is demonstrated using 4-heptyl-4'-cyanobiphenyl (7CB) to dope a classic cathode (ZnO and SnO) or an anode interlayer [poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)]. Because of the enhanced light absorption, improved physical contact between a photoactive layer and an interlayer, and increased carrier recombination, all of the devices based on a 7CB-doped interlayer show increased short-circuit current density (), fill factor (FF), and power conversion efficiency (PCE) compared to the corresponding undoped interlayer, regardless it is the anode interlayer or the cathode interlayer, which is a rare phenomenon in the interlayer modification field.

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting M and Ameliorates Pulmonary Inflammation.

The coronavirus disease 2019 (COVID-19) has spread widely around the world and has seriously affected the human health of tens of millions of people. In view of lacking anti-virus drugs target to SARS-CoV-2, there is an urgent need to develop effective new drugs. In this study, we reported our discovery of SARS-CoV-2 M inhibitors.

Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway.

Inflammation is a defense response of the body to stimuli. Lung injury caused by external stimuli can stimulate inflammatory cells to accumulate at the site of injury and secrete cytokines. Pinocembrin is a flavonoid with anti-inflammatory effects.

A Cost-Effective, Aqueous-Solution-Processed Cathode Interlayer Based on Organosilica Nanodots for Highly Efficient and Stable Organic Solar Cells.

The performance and industrial viability of organic photovoltaics are strongly influenced by the functionality and stability of interface layers. Many of the interface materials most commonly used in the lab are limited in their operational stability or their materials cost and are frequently not transferred toward large-scale production and industrial applications. In this work, an advanced aqueous-solution-processed cathode interface layer is demonstrated based on cost-effective organosilica nanodots (OSiNDs) synthesized via a simple one-step hydrothermal reaction.